Issues

Summary: Discussion of the current understanding of ATM and ATR activation, and their relevance in maintaining cell physiology and in cancer.

Summary: Longin domains play fundamental roles in intracellular trafficking by regulating the membrane localization and membrane fusion activity of SNARE proteins.

Summary: Ubiquitylation of CD98 regulates its expression, and is a mechanism to limit the clonal expansion of T lymphocytes and potentially of other normal and transformed cells.

Highlighted Article: This study characterizes the interaction between Drosophila Rop and the exocyst in control of dendritic morphogenesis, and demonstrates how membrane is allocated in dendrites to facilitate growth.

Summary: Cdc42 regulates tubulogenesis in the kidney by controlling the polarity Par complex (Par3–Par6–aPKC–Cdc42) and the cytoskeletal proteins N-Wasp and ezrin.

Highlighted Article: Decidual-stromal-cell-derived neuregulin-1 induces ErbB2–ErbB3 heterodimerization in extravillous trophoblasts and stabilizes trophoblast differentiation through suppression of apoptosis.

Summary: p114RhoGEF governs cell motility and lumen formation, suggesting that cell movement is necessary for consolidating multiple lumens into a single lumen.

Highlighted Article: A range of genetically targeted lipid probes were used to track and quantify phosphoinositide turnover in the photoreceptors of completely intact living flies, with a precision unsurpassed in other systems.

Summary: This study reveals a new signaling pathway that mediates TCR-induced LFA-1 activation, involving SWAP-70-like adaptor of T cells (SLAT).

Highlighted Article: Luman, an ER-resident transcription factor, regulates the multinucleation of osteoclasts by promoting cell fusion of mononuclear osteoclasts through DC-STAMP induction and transportation during osteoclastogenesis.

Summary: A 3D co-culture system comprising non-transformed epithelial cells and transformed carcinoma cells demonstrates that carcinoma cells sequentially induce sE-cad-dependent lumen filling and EMT.

Summary: Exposure to UV irradiation causes genome-wide changes in chromatin accessibility and epigenetic state.

Summary: The insulin receptor and TORC1 pathways independently control cytoplasmic and nuclear functions of Drosophila Lipin, and Lipin, in turn, modulates cellular responses to growth factor signaling.

Summary: An analysis of SNX5-knockout mice shows that SNX5 is essential for the biogenesis of macropinosomes from dorsal ruffles and that dorsal ruffles provide a major contribution to macropinocytosis in activated macrophages.

Summary: In contrast to textbook knowledge, the phosphorylation of translation initiation factor eIF2α is not required for UV-induced inhibition of protein synthesis, which we show in three different cell types.

Summary: Our studies describe a new, multi-level paradigm in which allosteric modifications alter the ability of the scaffold protein Shoc2 to actively accelerate transmission of ERK1/2 signals.

Summary: In mouse oocytes, Ca_V3.2 T-type channels have previously unrecognized roles in supporting accrual of Ca²⁺ stores during oocyte maturation and in mediating Ca²⁺ influx following fertilization.

Highlighted Article: We have developed Sqstm1-GFP knock-in mice, which are useful for elucidating the molecular mechanisms of cellular events, including autophagy, and various diseases in which Sqstm1 plays a role.