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IN THIS ISSUE

STICKY WICKET

CELL SCIENTISTS TO WATCH

MEETING REPORT

OPINION

Summary: In this Opinion article we discuss the reliability of ROS and RNS detection in HSCs, and propose approaches to examine the levels of ROS and RNS specifically in HSCs in vitro and in vivo.

COMMENTARY

Summary: The limits of the cellular resilience to protein misfolding are outlined, and the possibility of pushing these limits to help cells survive and to avoid protein quality control catastrophes is discussed.

SHORT REPORT

Summary: In endothelial cells, the membrane-bound LPA-degrading enzyme LPP3 is specifically expressed at cell–cell contact sites, thereby localizing the signal evoked by extracellularly produced LPA.

RESEARCH ARTICLES

Highlighted Article: We provide data suggesting that sphingosine 1-phosphate signalling could be a potential drug target for Krabbe disease and perhaps other demyelinating illnesses, in addition to multiple sclerosis.

Summary: Fluorescent labeling of Cx36-HaloTag revealed that turnover occurs on a different time scale than phosphorylation-driven plasticity. Cx36-HaloTag is also partially mobile within gap junctions.

Highlighted Article: By activating ERK1/2, the protein tyrosine phosphatase SHP2 tunes the extent of the epithelial–mesenchymal transition observed in carcinoma cells in response to different growth factors.

Summary: The yeast GSK-3 kinase controls astral microtubule functions by regulating the interaction of the microtubule-stabilising kinesin Kip2 with microtubules and its processivity factor Bim1/EB1.

Highlighted Article: This work reveals, at a molecular level, that seedlings of large-seeded plants can withstand drought stresses efficiently because of ABA signaling mediating a ARF2–ANT–COR15A gene cascade.

Summary: Evidence is presented for a novel role of Rac1 in stimulating β-catenin–LEF-1 complex formation.

Highlighted Article: The gap junction protein Cx30 was found to be an unusually stable, long-lived connexin, which might underlie its specific role in the epidermis and cochlea.

Summary: The HER2 oncogene alters the epithelial morphogenetic program and inhibits MEF2 transcriptional programs. Reactivation of MEF2s re-established normal acini morphogenesis.

Highlighted Article: Eukaryotic initiation factor 6 (eIF6) acts to facilitate Sp1 recruitment to the TGF-β1 promoter through H2A.Z depletion and thus results in increased TGF-β1 transcription, which contributes to myofibroblast differentiation.

Summary: In Dictyostelium, compromised N-glycosylation, but not ER stress, caused by tunicamycin treatment or alg9 mutation, partially suppresses the developmental arrest in tgrB1-tgrC1-defective mutants.

Summary: Integrin-αv plays a crucial role in regulating skin tissue generation and tumor invasion through a focal-adhesion-independent FAK–p38–p90RSK–c-Myc signaling axis.

Summary: Conformational changes in the helix D coiled-coil of the Kv7.2 channel affect interactions with calmodulin, which binds to helices AB, modulating channel gating and PIP2 sensitivity.

CORRECTIONS

ARTICLES OF INTEREST IN OTHER COB JOURNALS

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