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IN THIS ISSUE

STICKY WICKET

CELL SCIENTISTS TO WATCH

OPINION

Summary: Recent advances in our understanding of cell adhesion are integrated to develop a non-arbitrary definition of cell adhesion strength, suited to unify the quantitative description of tissue mechanical processes.

COMMENTARY

Imaging Series

Summary: The principal experimental and analytical requirements to visualize and trace single endogenous mRNA particles in living cells are discussed, and the most recent quantitative results are highlighted.

SHORT REPORTS

Highlighted Article: The endocytic machinery, including the type 1 myosin Myo1, is required to establish a quiescence response to low-phosphate stress in fission yeast.

Summary: Super-resolution fluorescence microscopy analysis reveals the fine details of the molecular architecture of hemidesmosomes in cultured keratinocytes and skin.

RESEARCH ARTICLES

Highlighted Article: Quantitative analysis in S. pombe reveals that chromosome oscillations are dispensable for kinetochore congression in mitosis. Kinesin-8 controls chromosome congression through length-dependent pulling forces.

Summary: Adhesion persistence to P-selectin is reduced in metastatic but not leukocyte-like cells. A system that identifies selectin adhesion antagonist doses that modulate cell adhesion is presented.

Highlighted Article: Rapsyn, a cytoplasmic AChR-associated scaffold protein, serves as a clustering agent of lysosomes at the juxtanuclear region of cells that do not express AChRs.

Summary: The stimulation of the Sec5–GEF-H1 interaction through dexamethasone-induced SGK1 activity is crucial for organizing adhesion and, subsequently, generating cellular tension.

Highlighted Article:In vivo evidence showing that PP6 in oocytes suppresses Aurora A activity in MII and is crucial for MII exit, euploid egg production and female fertility.

Summary: Constitutive receptor internalization is required for IL-4R signalling. Increased endosomal concentrations allow receptor dimerization that is disfavoured at endogenous plasma membrane densities.

Highlighted Article: The formin mDia1 nucleates linear actin filaments that serve as mother filaments for initial activation of the Arp2/3 complex and formation of lamellipodia and ruffles.

Summary: Our studies on GAK- and auxilin-knockout mice show that the only essential domains of GAK and auxilin in the brain are the clathrin-binding domain and the J-domain that binds to Hsc70.

Summary: A new player in male fertility – ICA1L forms BAR-domain complexes with PICK1 and is crucial for acrosome formation in spermiogenesis.

CORRECTION

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