Issues
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Cover image
Cover Image
Cover: Mouse embryonic fibroblasts (MEFs) cultured on glass coverslips were fixed and stained for actin filaments (green), microtubules (red), and nuclear DNA (DAPI, blue). See article by Kim et al. (pp. 3375–3385).
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IN THIS ISSUE
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CELL SCIENTISTS TO WATCH
COMMENTARY
Building an integrated model of chromosome congression
Summary: This Commentary documents recent advances concerning the two kinetochore-based force-generating mechanisms that drive mitotic chromosome congression in vertebrate cells.
RESEARCH ARTICLES
Volume regulation and shape bifurcation in the cell nucleus
Highlighted Article: Depending on the physical environment of the cell, the nuclear volume can change dramatically. Cytoskeletal filaments and motors are involved in regulating nuclear volume.
Binding partners of the kinase domains in Drosophila obscurin and their effect on the structure of the flight muscle
Summary: Obscurin is a titin-like protein in Drosophila muscle, which has two pseudokinase domains. These bind ligands essential for the correct assembly of the filament lattice.
mRNA encoding Sec61β, a tail-anchored protein, is localized on the endoplasmic reticulum
Highlighted Article: The mRNA encoding certain tail-anchored proteins is directly localized to the surface of the endoplasmic reticulum, facilitating the insertion of newly synthesized proteins into the membrane.
KCNK1 inhibits osteoclastogenesis by blocking the Ca2+ oscillation and JNK–NFATc1 signaling axis
Summary: The inwardly rectifying K+ channel KCNK1 negatively regulates osteoclast differentiation.
A Chlamydia effector recruits CEP170 to reprogram host microtubule organization
Highlighted Article: Chlamydia trachomatis is an obligate intracellular pathogen. Here, we describe how the Chlamydia virulence protein IPAM interacts with the host protein CEP170 to reprogram host MT organization.
Vinculin phosphorylation at residues Y100 and Y1065 is required for cellular force transmission
Summary: Src-mediated phosphorylation on Y100 and Y1065 is a prerequisite for vinculin activation, and controls cytoskeletal mechanics by regulating force transmission between the actin cytoskeleton and focal adhesion proteins.
Induction of lateral lumens through disruption of a monoleucine-based basolateral-sorting motif in betacellulin
Highlighted Article: The EGFR ligand betacellulin contains a cytoplasmic basolateral-sorting motif. Mistrafficking of betacellulin, but not other EGFR ligands, induces EGFR-dependent lateral lumens in polarized MDCK cells.
Endomembrane PtdIns(3,4,5)P3 activates the PI3K–Akt pathway
Summary: It had previously been understood that Akt activation occurs solely at the plasma membrane. We show that PtdIns(3,4,5)P3-dependent in situ activation of Akt can occur in subcellular compartments.
The lysine demethylase LSD1 is required for nuclear envelope formation at the end of mitosis
Highlighted Article: Interfering with lysine demethylase LSD1 function severely affects nuclear envelope and pore complex reformation at the end of mitosis, indicating that changes on the chromatin landscape regulate these processes.
The NMDA receptor functions independently and as an LRP1 co-receptor to promote Schwann cell survival and migration
Summary: The NMDA receptor and LRP1 function as co-receptors in Schwann cells, activating cell signaling in response to protein ligands and promoting cell survival and migration.
Regulation of the neuronal KCNQ2 channel by Src – a dual rearrangement of the cytosolic termini underlies bidirectional regulation of gating
Summary: Src regulates the KCNQ2 channel through a dual rearrangement of cytosolic termini that underlies upregulation of single-channel gating and a reduction in the number of functional channels.
The caspase-3–p120-RasGAP module generates a NF-κB repressor in response to cellular stress
Summary: Mild caspase activation in cells subjected to non-lethal doses of stress generates an N-terminal p120 RasGAP fragment that inhibits NF-κB activity.
CORRECTION
A local VE-cadherin and Trio-based signaling complex stabilizes endothelial junctions through Rac1
ARTICLES OF INTEREST IN OTHER COB JOURNALS
From Development
Interviews with Biologists @ 100 conference speakers
Explore our interviews with keynote speakers from the Biologists @ 100 conference, hosted to celebrate our publisher’s 100th anniversary, where we discuss climate change and biodiversity with Hans-Otto Pörtner and Jane Francis, health and disease with Charles Swanton and Sadaf Farooqi, and emerging technologies with Manu Prakash and Jennifer Lippincott-Schwartz.
Introducing our new Associate Editors
In this Editorial, JCS Editor-in-Chief Michael Way welcomes five new Associate Editors to the JCS team. These Associate Editors will expand our support for the wider cell biology community and handle articles in immune cell biology, proteostasis, imaging and image analysis, plant cell biology, and stem cell biology and modelling.
The spatial choreography of mRNA biosynthesis
In their Review, André Ventura-Gomes and Maria Carmo-Fonseca detail the latest research progress and technological advancements that are helping to unlock how nuclear organisation underpins control of gene transcription and pre-mRNA splicing.
JCS-FocalPlane Training Grants
Early-career researchers - working in an area covered by JCS - who would like to attend a microscopy training course, please apply. Deadline dates for 2025 applications: 6 June 2025 (decision by week commencing 28 July 2025) and 5 September 2025 (decision by week commencing 20 October 2025).
The emerging roles of the endoplasmic reticulum in mechanosensing and mechanotransduction
In their Review, Jonathan Townson and Cinzia Progida highlight recently emerging evidence for a role of the endoplasmic reticulum in enabling a cell to sense and respond to changes in the extracellular mechanical environment.
