Issues
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Cover image
Cover Image
Cover: Bright-field and immunofluorescence microscopy image of wild-type mouse melanocytes expressing mutated STX13 (a recycling endosomal Qa-SNARE), which results in its mislocalisation to melanosomes. Green, mutant STX13; red, a melanosome-resident protein TYRP1; blue, pseudocoloured melanosomes captured with bright-field microscopy. See article by R. A. Jani et al. (pp. 3263–3276).
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IN THIS ISSUE
STICKY WICKET
OBITUARY
CELL SCIENCE AT A GLANCE
Cellular functions of Rab GTPases at a glance
Summary: Rab GTPases and their effectors control intracellular membrane traffic and thus regulate numerous physiological processes, including protein sorting, vesicle motility and vesicle tethering.
COMMENTARY
Different functional modes of BAR domain proteins in formation and plasticity of mammalian postsynapses
Summary: A review of recent insights into the postsynaptic functions of BAR domain proteins. It is proposed that these proteins have four general, not mutually exclusive, functional modes.
RESEARCH ARTICLES
Binding of SGTA to Rpn13 selectively modulates protein quality control
Highlighted Article: Binding of SGTA to the proteasome delays substrate degradation, thereby providing a mechanism for potentially viable proteins to be rescued for reuse.
The miR-199–dynamin regulatory axis controls receptor-mediated endocytosis
Summary: A characterization of how an intronic miRNA encoded in the dynamin genes controls cellular endocytosis by targeting multiple components of the endocytic machinery.
Cooperative interactions of LPPR family members in membrane localization and alteration of cellular morphology
Highlighted Article: This paper presents the results of a large-scale proteome analysis to determine LPPR1-interacting proteins and identifies a functional cooperation between LPPR family members.
TPD52 expression increases neutral lipid storage within cultured cells
Summary: Tumor protein D52 (TPD52) increases lipid droplet numbers and fatty acid incorporation into triglyceride, possibly through relevant functions at both the Golgi complex and lipid droplets.
The Drosophila retinoblastoma protein, Rbf1, induces a Debcl- and Drp1-dependent mitochondrial apoptosis
Highlighted Article: Debcl, a Drosophila pro-apoptotic Bcl-2 family member, can induce mitochondrial fragmentation by binding the pro-fission protein Drp1, which induces mitochondrial ROS accumulation, JNK pathway activation and cell death.
The pro-inflammatory cytokine 14-3-3ε is a ligand of CD13 in cartilage
Summary: 14-3-3 might directly bind to CD13, which transmits a signal in chondrocytes to induce a catabolic phenotype similar to that observed in osteoarthritis.
STX13 regulates cargo delivery from recycling endosomes during melanosome biogenesis
Highlighted Article: The SNAREs STX13 and VAMP7 mutually regulate their localization in melanocytes and control the cargo delivery to the melanosome during its biogenesis.
Centrosomal AKAP350 and CIP4 act in concert to define the polarized localization of the centrosome and Golgi in migratory cells
Summary: The present study establishes the participation of AKAP350 and CIP4 in centrosome positioning in migratory cells, and demonstrates the direct connection between the two cytoskeletal regulatory proteins in this process.
Characterization of Cep85 – a new antagonist of Nek2A that is involved in the regulation of centrosome disjunction
Summary: Cep85 acts as a binding partner of Nek2A to prevent premature centrosome separation in interphase by inhibiting Nek2A activity.
Dictyostelium Nramp1, which is structurally and functionally similar to mammalian DMT1 transporter, mediates phagosomal iron efflux
Summary: The Dictyostelium Nramp1 transporter confers resistance to pathogenic bacteria by mediating iron efflux from phagosomes. Nramp1 and the related NrampB (formerly Nramp2) display differences in metal selectivity, electrogenicity and H+ dependence.
Crucial role of TRPC6 in maintaining the stability of HIF-1α in glioma cells under hypoxia
Summary: TRPC6 regulates metabolism to affect HIF-1α stability and consequent glucose metabolism in human glioma cells under hypoxia.
RDGBα, a PtdIns-PtdOH transfer protein, regulates G-protein-coupled PtdIns(4,5)P2 signalling during Drosophila phototransduction
Summary: RDGB regulates PtdIns and PtdIns(4,5)P2 homeostasis during G-protein-activated phospholipase C signalling in Drosophila.
Promotion of periostin expression contributes to the migration of Schwann cells
Summary: Our data demonstrate that the expression of periostin is stimulated by the ErbB ligand NRG1 and promotes the migration of Schwann cell precursors.
ARTICLES OF INTEREST IN OTHER COB JOURNALS
From Development
Call for papers - Cilia and Flagella: from Basic Biology to Disease
We are welcoming submissions for our upcoming special issue: Cilia and Flagella: from Basic Biology to Disease. This issue will be coordinated by two Guest Editors: Pleasantine Mill (University of Edinburgh) and Lotte Pedersen (University of Copenhagen). Extended submission deadline: 31 March 2025.
History of our journals
As our publisher, The Company of Biologists, turns 100 years old, read about Journal of Cell Science’s journey and explore the history of each of our sister journals: Development, Journal of Experimental Biology, Disease Models & Mechanisms and Biology Open.
Introducing our new Associate Editors
In this Editorial, JCS Editor-in-Chief Michael Way welcomes five new Associate Editors to the JCS team. These Associate Editors will expand our support for the wider cell biology community and handle articles in immune cell biology, proteostasis, imaging and image analysis, plant cell biology, and stem cell biology and modelling.
Diversity of microtubule arrays in animal cells at a glance
In this Cell Science at a Glance article, Emma van Grinsven and Anna Akhmanova provide an overview of the diverse microtubule arrays present in differentiated animal cells and discuss how these arrays form and function.
JCS-FocalPlane Training Grants
Early-career researchers - working in an area covered by JCS - who would like to attend a microscopy training course, please apply. Deadline dates for 2025 applications: 7 March 2025 (decision by week commencing 21 April 2025) and 6 June 2025 (decision by week commencing 28 July 2025).
