Issues

Summary: Martin Schwartz suggests a different approach to scientific ethics that looks at the scientific process from the inside.

Summary: Caveolae and stress fibers are two essential players in the cell response to mechanical forces. The physical association of these two mechanosensors could ensure a coordinated response during mechanotransduction.

Summary: AMF and its Gp78 receptor regulate RER–mitochondria contacts, and Mfn1 and Mfn2 inhibit SER and RER–mitochondria contacts, respectively, defining new mechanisms of ER–mitochondria interaction.

Highlighted Article: Decreased membrane binding of PACSIN2 upon its PKC-mediated phosphorylation at serine 313 is shown to trigger the removal of caveolae from the plasma membrane.

Summary: γ-SNAP interacts with and disassembles a limited range of SNARE complexes, including endosomal SNAREs, and facilitates the trafficking of endocytosed EGFR and transferrin from early endosomes.

Highlighted Article: Confocal live-cell imaging combined with correlative cryogenic fluorescence microscopy and soft X-ray tomography provide new insights into the complex process of mitochondrial fission in mammalian cells.

Summary: Under basal and sterol-deficient conditions, SCAP in complex with SREBP is retrieved from the Golgi complex in a COPI-dependent manner after it has been transported from the ER.

Highlighted Article: Kinesin light chain 1, a component of the kinesin-1 motor protein, binds to the intracellular domain of the neural cell adhesion molecule and promotes its delivery to the cell surface.

Summary: The nuclear periphery proteins lamin-A/C, LAP2 and BAF1 are assembled into a protein complex in mitosis to regulate assembly and positioning of the mitotic spindle.

Highlighted Article: A dissection of how the fission yeast cell geometry network kinase Cdr2 coordinates the recruitment of its major effectors, Wee1, Cdr1 and Mid1, to regulate cell division spatially and temporally.

Summary: Interaction between the torsinA AAA+ protein and the LULL1 activator of ATP hydrolysis in the endoplasmic reticulum controls torsinA entry to the inner nuclear membrane, its site of activity.

Summary: 5-HT₇R–Cdc42-mediated signaling regulates the morphology and motility of dendritic cells, suggesting that 5-HT₇R could be a target for treatment in a variety of inflammatory disorders.

Summary: Discovery that the gene Stk40 represses adipogenesis through inhibition of C/EBP protein translation.

Summary: VAMP2, VAMP3 and VAMP8 can be removed from the plasma membrane by non-clathrin-mediated pathways and functionally associate with Shiga-toxin-driven clathrin-independent plasma membrane invaginations.

Summary: In fission yeast, large assemblies of the myosin-II proteins contribute to maintenance of the actomyosin contractile ring during cytokinesis, and not only to its constriction.

Summary: The Salt Overly Sensitive (SOS) pathway is thought to play essential roles in conferring salt tolerance in Arabidopsis. This work addresses how ANT regulates the SOS pathway.

Summary: Ciliary adenylyl cyclases AC5 and AC6 respond to stimulatory and inhibitory GPCRs to control PKA and, hence, transduce the Hedgehog signal.

Summary: In Drosophila and humans, the Mitf transcription factors directly control genes for all v-ATPase subunits, and together with the v-ATPase and TORC1, serve as a dynamic modulator of metabolism.