Issues

Summary: A review of the composition and spatio-temporal reorganization of receptor complexes for attractive and repulsive neurite growth factors, examining the implications for downstream signaling.

Summary: In this review, the main findings about the impact of mechanical forces (shear stress and cyclic strain) on the differentiation of mesenchymal stem cells into vascular cells are presented.

Summary: Cellugyrin-containing internal GLUT4-containing vesicles provide an insulin-sensitive reservoir to replenish GLUT4 storage vesicles following insulin-stimulated exocytosis of GLUT4.

Summary: This paper provides evidence that WNT/β-catenin signaling selectively inhibits the expression of a subset of NF-κB-dependent proinflammatory target genes by inhibiting RelA K314 acetylation by CBP.

Highlighted Article: In Drosophila, the old mother centriole that stays in the apical cytoplasm of the male germline stem cells is composed of triplets, whereas its daughter is always built from mixed doublets and triplets.

Summary: High levels of IFN-α and apoptotic microparticles lead to a pro-inflammatory environment through the synergistic increase of phosphorylated STAT1 when acting upon professional phagocytes.

Summary: Sphingolipids regulate telomere clustering by affecting the transcription of genes involved in telomere homeostasis in yeast.

Summary: Actomyosin assembly and myosin ATPase activity are not essential for mouse spinal neurulation. However, the ROCK–LIMK–cofilin pathway, which controls actin turnover and actomyosin disassembly, is necessary.

Summary: During oocyte meiotic maturation, Cdc6 accumulation is tightly coordinated with entry into meiosis II to avoid the direct inhibition of Cdk1 activity and, thus, unscheduled DNA replication.

Highlighted Article: The Drosophila TOR complex 2 is necessary for the formation of heat-induced cytoprotective stress granules, which can explain the heat sensitivity of TORC2 mutant flies.

Summary: Description of a simple and dynamic measure of Akt signaling activity in living cells that will provide new insights into how Akt regulates its biological responses.

Highlighted Article: The early ESCRT machinery has a dual role in limiting intracellular Aβ accumulation through targeting of APP and its processing products to lysosomes for degradation, and promoting Aβ secretion.

Summary: 3D electron microscopy reconstructs the highly organised structure of the infranuclear region of the cochlear inner hair cell, which supports synaptic functions.

Highlighted Article: The ciliary regulator Rab8 is co-opted by T-cells during the assembly of the immune synapse to promote the VAMP-3-dependent step of polarized T-cell receptor recycling.

Highlighted Article: Loss-of-function studies in the moss Physcomitrella patens demonstrate that the ROP-family of proteins is crucial for cell adhesion and polarized growth.