Issues

Summary: Galectin crosslinking of plasma membrane glycans regulates diffusion, compartmentalization and endocytosis of glycoproteins and glycolipids impacting immunity, cancer and metabolism.

Summary: Mechanosensing and -transduction is important for inflammation. This Commentary discusses the regulation of endothelial cell stiffness and its relevance for leukocyte adhesion, crawling and transendothelial migration.

Summary: Absence or aggregation of α-synuclein induces a selective increase and redistribution of synapsin III, reorganizing synaptic vesicle pools, which could have implications for dopamine neuron degeneration in Parkinson's disease.

Highlighted Article: Transcriptional upregulation of Girdin expression and Girdin–Gαi3 signaling play crucial roles in regulating epithelial apicobasal polarity through the PAR complex.

Summary: F-BAR protein Rga7p is required for the timely delivery of a β-glucan synthetase (Bgs4p) to the cleavage furrow during cytokinesis of fission yeast.

Summary: TM9 proteins facilitate transport to the cell surface of proteins with gylcine-rich transmembrane domains. They might represent a new class of cargo receptors controlling transport in the secretory pathway.

Summary: The I-BAR protein Ivy1 is a new effector of the yeast GTPase Ypt7, which localizes to membrane intrusions and affects the homeostasis of vacuole membranes.

Summary: Investigation of the intracellular dynamics of plasmolipin reveals that it assembles potential myelin membrane precursor domains at the Golgi complex by oligomerizing and attracting liquid-ordered lipids.

Summary: The transcription factors Brn2 and Zic1 cooperate to regulate the neurogenic gene expression programme of retinoic-acid-treated mouse embryonic stem cells.

Highlighted Article: In mouse ooctytes, different isoforms of pyruvate dehydrogenase kinase have differing effects on the assembly of the spindle, chromosome alignment and ATP content.

Summary: Amyloid-β is a causative factor in Alzheimer's disease. In the mouse brain, its levels are controlled by the CALHM1 ion channel promoting its clearance by insulin-degrading enzyme.

Summary: An automated high-content microscopy screen is used to quantitatively explore the role of Rab family GTPases in Golgi-to-ER traffic, revealing that nine proteins are strong regulators of this process.

Highlighted Article: In the kidney collecting duct, CaSR signaling activated by luminal Ca²⁺ antagonizes vasopressin action, thus reducing AQP2-mediated water reabsorption and reducing the risk of Ca²⁺ saturation.

Highlighted Article: Three new T. brucei flagellum attachment zone filament proteins are identified, and it is shown that assembly of the filament occurs at the proximal base and is essential for filament protein stability.

Summary: Retrograde transport is not required for cytosolic translocation of the B-subunit of Shiga toxin, revealing new facets of the endosomal escape process with relevance to antigen cross-presentation.

Summary: A genome-wide RNAi screen is used to identify several conserved regulators of nuclear actin import and polymerization, and thus links control of nuclear actin to many cellular processes.