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Summary: A systematic analysis of the non-muscle myosin II literature reveals the multitude of cellular processes in which contractility plays a role and the complex protein interaction network regulating it.


Summary: The multiprotein SEA/GATOR complex is a major upstream regulator of TORC1. This Commentary describes its structural and functional features, and provides an overview of the consequences of its deregulation in cancer.


Highlighted Article: An interaction between the juxtamembrane domain of synaptotagmin 1 and the pleckstrin homology domain of dynamin 1 regulates endocytic fission in chromaffin cells.


Highlighted Article: Intracellular VEGF signaling in endothelial cells regulates mitochondria function and levels of FOXO1.

Summary: JNK2-mediated phosphorylation of GRASP65 at Ser277 has a crucial role in the G2-specific separation of the Golgi stacks that is required for the G2/M transition.

Summary: MAL, an integral membrane protein component of the apical transport machinery, regulates the condensation of membranes at the ciliary base for efficient primary ciliogenesis in epithelial MDCK cells.

Highlighted Article: The epithelial cholinergic system activates a signaling pathway that regulates paracellular permeability by modulating the content and distribution of the tight junction protein claudin-4.

Summary: Akt-mediated phosphorylation of residue S227 within the nuclear localization signal of hTERT increases the binding affinity for importin α and promotes nuclear import of hTERT.

Summary: GABAB receptor activation induces Rap1 activation to promote its own surface expression by stimulating receptor recycling, thereby providing a potential explanation for the long-lasting action of GABA.

Highlighted Article: miRNA-deficient spermatocytes display frequent sex chromosome fusions and fail to progress through meiosis in a process that is probably mediated by dysregulation of Atm.

Summary: Wntless-mediated Wnt5b secretion modulates the proliferation of chondrogenic cells through fine-tuning regional Fgf3 expression during the development of craniofacial cartilages.

Summary: Mecp2 suppresses neural cell development by suppressing the Id1–Her2 (Hes5 in mammals) axis, which is a mechanism that might contribute to the later motor and cognitive dysfunctions in Rett syndrome.

Highlighted Article: The architectures of the BBSome and exocyst are revealed by a visible immunoprecipitation assay, which can detect interactions between fluorescent fusion proteins without performing western blotting.

Summary: In addition to its role in osmoregulation, the contractile vacuole of Trypanosoma cruzi, the agent of Chagas disease, has a role in the biogenesis of acidocalcisomes.

Summary: Cell surface heparan sulfate proteoglycans act as platforms for hedgehog morphogen assembly and storage on producing cells, but also act as a scaffold for factors involved in their regulated release.


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