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Cover image
Cover Image
Cover: Shown is a colour-depth-coded projection of a mouse retina AII amacrine cell injected with Alexa Fluor 488. AII cells are interneurons that are important for dim-light vision and feed rod signals into the cone pathways. Depending on the response of these bipolar cells to light, they are divided into ‘ON’ and ‘OFF’ cells; whereas the former contain metabotropic glutamate receptors and respond to light signals by depolarizing, the latter contain ionotropic receptors and hyperpolarize. AII cells receive input from ON rod bipolar cells at their distal dendrites (green-yellow), and transfer signals through chemical synapses to OFF cone bipolar and ganglion cells from proximal dendrites (blue-purple). Distally, AII cells also establish two types of Cx36-containing gap junction – to other AII cells and to ON cone bipolar cells – that differ in function and regulation, and are assembled through distinct, discriminatory mechanisms. See article by A. Meyer et al. (pp. 1190–1202).
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Call for papers: Cell Biology of Mitochondria
We are welcoming submissions for our upcoming special issue: Cell Biology of Mitochondria. This issue will be coordinated by two Guest Editors: Ana J. Garcia-Saez (University of Cologne, Germany) and Heidi McBride (McGill University, Canada). Submission deadline: 1 November 2024.
Biologists @ 100 - join us in Liverpool in March 2025
We are excited to invite you to a unique scientific conference, celebrating the 100-year anniversary of The Company of Biologists, and bringing together our different communities. The conference will incorporate the Spring Meetings of the BSCB and the BSDB, the JEB Symposium Sensory Perception in a Changing World and a DMM programme on antimicrobial resistance. Find out more and register your interest to join us in March 2025 in Liverpool, UK.
Intermediate filaments at a glance
Although intermediate filaments are known for their structural support, emerging evidence reveals their involvement in various cellular processes, underscoring their significance in disease development and progression. In this Cell Science at a Glance article, Leila Coelho-Rato and colleagues discuss the established classes of intermediate filaments and their general features, their functions beyond structural support and recent advances in the field.
JCS-FocalPlane Training Grants
Early-career researchers - working in an area covered by JCS - who would like to attend a microscopy training course, please apply. Deadline dates for 2024 applications: 7 September (decision by week commencing 8 October 2024); 22 November (decision by week commencing 16 December).
Immune Cell Interactions in Development, Homeostasis and Immunity
Early-career researchers interested in immune cell interactions, apply now for one of the ten funded places at this Workshop, which will take place 23-26 February 2025. Application deadline: 23 September.
