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Cover image
Cover Image
Cover: Shown is a colour-depth-coded projection of a mouse retina AII amacrine cell injected with Alexa Fluor 488. AII cells are interneurons that are important for dim-light vision and feed rod signals into the cone pathways. Depending on the response of these bipolar cells to light, they are divided into ‘ON’ and ‘OFF’ cells; whereas the former contain metabotropic glutamate receptors and respond to light signals by depolarizing, the latter contain ionotropic receptors and hyperpolarize. AII cells receive input from ON rod bipolar cells at their distal dendrites (green-yellow), and transfer signals through chemical synapses to OFF cone bipolar and ganglion cells from proximal dendrites (blue-purple). Distally, AII cells also establish two types of Cx36-containing gap junction – to other AII cells and to ON cone bipolar cells – that differ in function and regulation, and are assembled through distinct, discriminatory mechanisms. See article by A. Meyer et al. (pp. 1190–1202).
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Interviews with Biologists @ 100 conference speakers
Explore our interviews with keynote speakers from the Biologists @ 100 conference, hosted to celebrate our publisher’s 100th anniversary, where we discuss climate change and biodiversity with Hans-Otto Pörtner and Jane Francis, health and disease with Charles Swanton and Sadaf Farooqi, and emerging technologies with Manu Prakash and Jennifer Lippincott-Schwartz.
Introducing our new Associate Editors
In this Editorial, JCS Editor-in-Chief Michael Way welcomes five new Associate Editors to the JCS team. These Associate Editors will expand our support for the wider cell biology community and handle articles in immune cell biology, proteostasis, imaging and image analysis, plant cell biology, and stem cell biology and modelling.
The spatial choreography of mRNA biosynthesis
In their Review, André Ventura-Gomes and Maria Carmo-Fonseca detail the latest research progress and technological advancements that are helping to unlock how nuclear organisation underpins control of gene transcription and pre-mRNA splicing.
JCS-FocalPlane Training Grants
Early-career researchers - working in an area covered by JCS - who would like to attend a microscopy training course, please apply. Deadline dates for 2025 applications: 6 June 2025 (decision by week commencing 28 July 2025) and 5 September 2025 (decision by week commencing 20 October 2025).
The emerging roles of the endoplasmic reticulum in mechanosensing and mechanotransduction
In their Review, Jonathan Townson and Cinzia Progida highlight recently emerging evidence for a role of the endoplasmic reticulum in enabling a cell to sense and respond to changes in the extracellular mechanical environment.
