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Volume 126, Issue 21

November 2013

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Cover image

Cover Image

Cover: Giant rubber duck inflatable sculpture created by Dutch artist Florentijn Hofman on the Dojima River in Osaka, Japan. Image courtesy of Tamotsu Yoshimori. See editorial by M. Way and S. Ahmad (p. 4807).
Table of contents

ISSN 0021-9533

EISSN 1477-9137

In this issue

EDITORIAL
MEETING REPORT
CELL SCIENCE AT A GLANCE
COMMENTARY
SHORT REPORT
RESEARCH ARTICLE
CORRECTION
ARTICLE OF INTEREST IN OTHER COB JOURNALS
- FROM DEVELOPMENT
IN THIS ISSUE

EDITORIAL

New JCS Editor

Michael Way,Sharon A. Ahmad

Extract

View articletitled, New JCS Editor

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MEETING REPORT

Meeting report – TGF-β superfamily: signaling in development and disease

Ying E. Zhang,Stuart J. Newfeld

Abstract

View articletitled, Meeting report – TGF-β superfamily: signaling in development and disease

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CELL SCIENCE AT A GLANCE

Eukaryotic ribosome biogenesis at a glance

Emma Thomson,Sébastien Ferreira-Cerca,Ed Hurt

Abstract

View articletitled, Eukaryotic ribosome biogenesis at a glance

Supplementary information

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COMMENTARY

Plant leaf senescence and death – regulation by multiple layers of control and implications for aging in general

Hye Ryun Woo,Hyo Jung Kim,Hong Gil Nam,Pyung Ok Lim

Abstract

View articletitled, Plant leaf senescence and death – regulation by multiple layers of control and implications for aging in general

Supplementary information

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SHORT REPORT

Na_V1.5 Na⁺ channels allosterically regulate the NHE-1 exchanger and promote the activity of breast cancer cell invadopodia

Lucie Brisson,Virginie Driffort,Lauriane Benoist,Mallorie Poet,Laurent Counillon,Ester Antelmi,Rosa Rubino,Pierre Besson,Fabien Labbal,Stéphan Chevalier,Stephan J. Reshkin,Jacques Gore,Sébastien Roger

Abstract

View articletitled, NaV1.5 Na+ channels allosterically regulate the NHE-1 exchanger and promote the activity of breast cancer cell invadopodia

Supplementary information

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Restricted mitochondrial protein acetylation initiates mitochondrial autophagy

Bradley R. Webster,Iain Scott,Kim Han,Jian H. Li,Zhongping Lu,Mark V. Stevens,Daniela Malide,Yong Chen,Leigh Samsel,Patricia S. Connelly,Mathew P. Daniels,J. Philip McCoy, Jr,Christian A. Combs,Marjan Gucek,Michael N. Sack

Abstract

View articletitled, Restricted mitochondrial protein acetylation initiates mitochondrial autophagy

Supplementary information

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A core hSSB1–INTS complex participates in the DNA damage response

Feng Zhang,Teng Ma,Xiaochun Yu

Abstract

View articletitled, A core hSSB1–INTS complex participates in the DNA damage response

Supplementary information

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Soluble amyloid-β precursor protein binds its cell surface receptor in a cooperative fashion with glypican and syndecan proteoglycans

Constanze Reinhard,Marianne Borgers,Guido David,Bart De Strooper

Abstract

View articletitled, Soluble amyloid-β precursor protein binds its cell surface receptor in a cooperative fashion with glypican and syndecan proteoglycans

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RESEARCH ARTICLE

Pin1 acts as a negative regulator of the G2/M transition by interacting with the Aurora-A–Bora complex

Yu-Cheng Lee,Jenny Que,Yu-Chia Chen,Jen-Tai Lin,Yih-Cherng Liou,Po-Chi Liao,Yu-Peng Liu,Kuen-Haur Lee,Li-Ching Lin,Michael Hsiao,Liang-Yi Hung,Chi-Ying Huang,Pei-Jung Lu

Abstract

View articletitled, Pin1 acts as a negative regulator of the G2/M transition by interacting with the Aurora-A–Bora complex

Supplementary information

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A Serrate–Notch–Canoe complex mediates essential interactions between glia and neuroepithelial cells during Drosophila optic lobe development

Raquel Pérez-Gómez,Jana Slováková,Noemí Rives-Quinto,Alena Krejci,Ana Carmena

Abstract

View articletitled, A Serrate–Notch–Canoe complex mediates essential interactions between glia and neuroepithelial cells during Drosophila optic lobe development

Supplementary information

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SNX15 links clathrin endocytosis to the PtdIns3P early endosome independently of the APPL1 endosome

Chris Danson,Edward Brown,Oliver J. Hemmings,Ian J. McGough,Sam Yarwood,Kate J. Heesom,Jeremy G. Carlton,Juan Martin-Serrano,Margaret T. May,Paul Verkade,Peter J. Cullen

Abstract

View articletitled, SNX15 links clathrin endocytosis to the PtdIns3P early endosome independently of the APPL1 endosome

Supplementary information

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Endocytosis of EGFR requires its kinase activity and N-terminal transmembrane dimerization motif

Raimond Heukers,Jeroen F. Vermeulen,Farzad Fereidouni,Arjen N. Bader,Jarno Voortman,Rob C. Roovers,Hans C. Gerritsen,Paul M. P. van Bergen en Henegouwen

Abstract

View articletitled, Endocytosis of EGFR requires its kinase activity and N-terminal transmembrane dimerization motif

Supplementary information

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The architectural relationship of components controlling mast cell endocytosis

Cédric Cleyrat,Anza Darehshouri,Karen L. Anderson,Christopher Page,Diane S. Lidke,Niels Volkmann,Dorit Hanein,Bridget S. Wilson

Abstract

View articletitled, The architectural relationship of components controlling mast cell endocytosis

Supplementary information

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Trans-induced cis interaction in the tripartite NGL-1, netrin-G1 and LAR adhesion complex promotes development of excitatory synapses

Yoo Sung Song,Hye-Jin Lee,Pavel Prosselkov,Shigeyoshi Itohara,Eunjoon Kim

Abstract

View articletitled, Trans-induced cis interaction in the tripartite NGL-1, netrin-G1 and LAR adhesion complex promotes development of excitatory synapses

Supplementary information

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Functional expression of the voltage-gated Na⁺-channel Na_v1.7 is necessary for EGF-mediated invasion in human non-small cell lung cancer cells

Thomas M. Campbell,Martin J. Main,Elizabeth M. Fitzgerald

Abstract

View articletitled, Functional expression of the voltage-gated Na+-channel Nav1.7 is necessary for EGF-mediated invasion in human non-small cell lung cancer cells

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Rab4b controls an early endosome sorting event by interacting with the γ-subunit of the clathrin adaptor complex 1

Laura Perrin,Sandra Lacas-Gervais,Jérôme Gilleron,Franck Ceppo,François Prodon,Alexandre Benmerah,Jean-François Tanti,Mireille Cormont

Abstract

View articletitled, Rab4b controls an early endosome sorting event by interacting with the γ-subunit of the clathrin adaptor complex 1

Supplementary information

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TRAPPIII is responsible for vesicular transport from early endosomes to Golgi, facilitating Atg9 cycling in autophagy

Kanae Shirahama-Noda,Shintaro Kira,Tamotsu Yoshimori,Takeshi Noda

Abstract

View articletitled, TRAPPIII is responsible for vesicular transport from early endosomes to Golgi, facilitating Atg9 cycling in autophagy

Supplementary information

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Embryonic ablation of osteoblast Smad4 interrupts matrix synthesis in response to canonical Wnt signaling and causes an osteogenesis-imperfecta-like phenotype

Valerie S. Salazar,Nicholas Zarkadis,Lisa Huang,Jin Norris,Susan K. Grimston,Gabriel Mbalaviele,Roberto Civitelli

Abstract

View articletitled, Embryonic ablation of osteoblast Smad4 interrupts matrix synthesis in response to canonical Wnt signaling and causes an osteogenesis-imperfecta-like phenotype

Supplementary information

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Spd1 accumulation causes genome instability independently of ribonucleotide reductase activity but functions to protect the genome when deoxynucleotide pools are elevated

Oliver Fleck,Rasmus Vejrup-Hansen,Adam Watson,Antony M. Carr,Olaf Nielsen,Christian Holmberg

Abstract

View articletitled, Spd1 accumulation causes genome instability independently of ribonucleotide reductase activity but functions to protect the genome when deoxynucleotide pools are elevated

Supplementary information

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Fission yeast nucleolar protein Dnt1 regulates G2/M transition and cytokinesis by downregulating Wee1 kinase

Zhi-yong Yu,Meng-ting Zhang,Gao-yuan Wang,Dan Xu,Daniel Keifenheim,Alejandro Franco,Jose Cansado,Hirohisa Masuda,Nick Rhind,Yamei Wang,Quan-wen Jin

Abstract

View articletitled, Fission yeast nucleolar protein Dnt1 regulates G2/M transition and cytokinesis by downregulating Wee1 kinase

Supplementary information

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ERK and phosphoinositide 3-kinase temporally coordinate different modes of actin-based motility during embryonic wound healing

Jingjing Li,Siwei Zhang,Ximena Soto,Sarah Woolner,Enrique Amaya

Abstract

View articletitled, ERK and phosphoinositide 3-kinase temporally coordinate different modes of actin-based motility during embryonic wound healing

Supplementary information

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Centrosomal protein CEP104 (Chlamydomonas FAP256) moves to the ciliary tip during ciliary assembly

Trinadh V. Satish Tammana,Damayanti Tammana,Dennis R. Diener,Joel Rosenbaum

Abstract

View articletitled, Centrosomal protein CEP104 (Chlamydomonas FAP256) moves to the ciliary tip during ciliary assembly

Supplementary information

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Disruption of disulfide restriction at integrin knees induces activation and ligand-independent signaling of α₄β₇

Kun Zhang,YouDong Pan,JunPeng Qi,Jiao Yue,MingBo Zhang,ChenQi Xu,GuoHui Li,JianFeng Chen

Abstract

View articletitled, Disruption of disulfide restriction at integrin knees induces activation and ligand-independent signaling of α4β7

Supplementary information

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N-terminus oligomerization regulates the function of cardiac ryanodine receptors

Spyros Zissimopoulos,Cedric Viero,Monika Seidel,Bevan Cumbes,Judith White,Iris Cheung,Richard Stewart,Loice H. Jeyakumar,Sidney Fleischer,Saptarshi Mukherjee,N. Lowri Thomas,Alan J. Williams,F. Anthony Lai

Abstract

View articletitled, N-terminus oligomerization regulates the function of cardiac ryanodine receptors

Supplementary information

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Mutation of a conserved residue enhances the sensitivity of analogue-sensitised kinases to generate a novel approach to the study of mitosis in fission yeast

Ye-Dee Tay,Avinash Patel,Daniel F. Kaemena,Iain M. Hagan

Abstract

View articletitled, Mutation of a conserved residue enhances the sensitivity of analogue-sensitised kinases to generate a novel approach to the study of mitosis in fission yeast

Supplementary information

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Embryonic stem cells stably expressing BDNF–GFP exhibit a BDNF-release-dependent enhancement of neuronal differentiation

Julia Leschik,Robert Eckenstaler,Katja Nieweg,Petra Lichtenecker,Tanja Brigadski,Kurt Gottmann,Volkmar Lessmann,Beat Lutz

Abstract

View articletitled, Embryonic stem cells stably expressing BDNF–GFP exhibit a BDNF-release-dependent enhancement of neuronal differentiation

Supplementary information

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A non-canonical role for Rgnef in promoting integrin-stimulated focal adhesion kinase activation

Nichol L. G. Miller,Christine Lawson,Elizabeth G. Kleinschmidt,Isabelle Tancioni,Sean Uryu,David D. Schlaepfer

Abstract

View articletitled, A non-canonical role for Rgnef in promoting integrin-stimulated focal adhesion kinase activation

Supplementary information

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CORRECTION

Mechanism of polarized lysosome exocytosis in epithelial cells

Jin Xu,Kimberly A. Toops,Fernando Diaz,Jose Maria Carvajal-Gonzalez,Diego Gravotta,Francesca Mazzoni,Ryan Schreiner,Enrique Rodriguez-Boulan,Aparna Lakkaraju

Extract

View articletitled, Mechanism of polarized lysosome exocytosis in epithelial cells

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ARTICLE OF INTEREST IN OTHER COB JOURNALS

FROM DEVELOPMENT

FGF signaling sustains the odontogenic fate of dental mesenchyme by suppressing β-catenin signaling

Chao Liu,Shuping Gu,Cheng Sun,Wenduo Ye,Zhongchen Song,Yanding Zhang,YiPing Chen

View articletitled, FGF signaling sustains the odontogenic fate of dental mesenchyme by suppressing β-catenin signaling

Direct interaction between two actin nucleators is required in Drosophila oogenesis

Margot E. Quinlan

View articletitled, Direct interaction between two actin nucleators is required in Drosophila oogenesis

IN THIS ISSUE

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Accepted manuscripts

Formin 3 stabilizes the cytoskeleton of Drosophila tendon cells, thus enabling them to resist muscle tensile forces

Helena Pissarek, Na Huang, Leanna H. Frasch, Hermann Aberle, Manfred Frasch

A dual-purification system to isolate mitochondrial subpopulations

Corey N. Cunningham, Jonathan G. Van Vranken, Jakeline Larios, Katarina Heyden, Steven P. Gygi, Jared Rutter

An endoplasmic reticulum-associated structure sequesters misassembled FG-Nups to help maintain NPC function

Madison Pletan, Emily Wang, Luke Gohmann, Billy Tsai

Compound screening in human airway basal cells identifies Wnt pathway activators as potential pro-regenerative therapies

Yuki Ishii, Jessica C. Orr, Marie-Belle El Mdawar, Denise R.Bairros de Pilger, David R. Pearce, Kyren A. Lazarus, Rebecca E. Graham, Marko Z. Nikolić, Robin Ketteler, Neil O. Carragher, Sam M. Janes, Robert E. Hynds

ATG9A vesicles are a subtype of intracellular nanovesicle

Mary Fesenko, Daniel J. Moore, Peyton Ewbank, Elizabeth Courthold, Stephen J. Royle

More accepted manuscripts

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Call for papers - Cilia and Flagella: from Basic Biology to Disease

We are welcoming submissions for our upcoming special issue: Cilia and Flagella: from Basic Biology to Disease. This issue will be coordinated by two Guest Editors: Pleasantine Mill (University of Edinburgh) and Lotte Pedersen (University of Copenhagen). Extended submission deadline: 31 March 2025.

History of our journals

As our publisher, The Company of Biologists, turns 100 years old, read about Journal of Cell Science’s journey and explore the history of each of our sister journals: Development, Journal of Experimental Biology, Disease Models & Mechanisms and Biology Open.

Introducing our new Associate Editors

In this Editorial, JCS Editor-in-Chief Michael Way welcomes five new Associate Editors to the JCS team. These Associate Editors will expand our support for the wider cell biology community and handle articles in immune cell biology, proteostasis, imaging and image analysis, plant cell biology, and stem cell biology and modelling.

Diversity of microtubule arrays in animal cells at a glance

In this Cell Science at a Glance article, Emma van Grinsven and Anna Akhmanova provide an overview of the diverse microtubule arrays present in differentiated animal cells and discuss how these arrays form and function.

JCS-FocalPlane Training Grants

Supporting microcopy training for early-career researchers in cell biology - apply for a grant up to £1,000

Early-career researchers - working in an area covered by JCS - who would like to attend a microscopy training course, please apply. Deadline dates for 2025 applications: 7 March 2025 (decision by week commencing 21 April 2025) and 6 June 2025 (decision by week commencing 28 July 2025).

Issues

Cover Image

EDITORIAL

MEETING REPORT

CELL SCIENCE AT A GLANCE

COMMENTARY

SHORT REPORT

RESEARCH ARTICLE

CORRECTION

ARTICLE OF INTEREST IN OTHER COB JOURNALS

FROM DEVELOPMENT

IN THIS ISSUE

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