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Volume 126, Issue 2

January 2013

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Cover image

Cover Image

Cover: Mouse embryonic fibroblasts were immunolabeled for β-catenin (red) to highlight adherens junctions, and stained with phalloidin to show F-actin (green). The image was captured by Megha Vaman Rao (Mechanobiology Institute Singapore, National University of Singapore) on an Applied Precision DeltaVision microsope using a 60× objective. Image courtesy of Ronen Zaidel-Bar (see related poster article (pp. 373–378).
Table of contents

ISSN 0021-9533

EISSN 1477-9137

In this issue

CELL SCIENCE AT A GLANCE
COMMENTARY
RESEARCH ARTICLE
IN THIS ISSUE
ARTICLE OF INTEREST IN OTHER COB JOURNALS
- FROM DEVELOPMENT

CELL SCIENCE AT A GLANCE

Cadherin adhesome at a glance

Ronen Zaidel-Bar

Extract

View articletitled, Cadherin adhesome at a glance

Supplementary information

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COMMENTARY

Cycling around cell–cell adhesion with Rho GTPase regulators

Jessica McCormack,Natalie J. Welsh,Vania M. M. Braga

Abstract

View articletitled, Cycling around cell–cell adhesion with Rho GTPase regulators

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E-cadherin–integrin crosstalk in cancer invasion and metastasis

Marta Canel,Alan Serrels,Margaret C. Frame,Valerie G. Brunton

Abstract

View articletitled, E-cadherin–integrin crosstalk in cancer invasion and metastasis

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Mechanosensitive systems at the cadherin–F-actin interface

Stephan Huveneers,Johan de Rooij

Abstract

View articletitled, Mechanosensitive systems at the cadherin–F-actin interface

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RESEARCH ARTICLE

Increased levels of reduced cytochrome b and mitophagy components are required to trigger nonspecific autophagy following induced mitochondrial dysfunction

Maika Deffieu,Ingrid Bhatia-Kiššová,Bénédicte Salin,Daniel J. Klionsky,Benoît Pinson,Stéphen Manon,Nadine Camougrand

Abstract

View articletitled, Increased levels of reduced cytochrome b and mitophagy components are required to trigger nonspecific autophagy following induced mitochondrial dysfunction

Supplementary information

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14-3-3 proteins interact with neurofilament protein-L and regulate dynamic assembly of neurofilaments

Linqing Miao,Junlin Teng,Jiqiang Lin,Xianzhi Liao,Jianguo Chen

Abstract

View articletitled, 14-3-3 proteins interact with neurofilament protein-L and regulate dynamic assembly of neurofilaments

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A non-catalytic role for inositol 1,3,4,5,6-pentakisphosphate 2-kinase in the synthesis of ribosomal RNA

Maria A. Brehm,Torsten Wundenberg,Jason Williams,Georg W. Mayr,Stephen B. Shears

Abstract

View articletitled, A non-catalytic role for inositol 1,3,4,5,6-pentakisphosphate 2-kinase in the synthesis of ribosomal RNA

Supplementary information

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Cytoplasmic mislocalization of p27 and CDK2 mediates the anti-migratory and anti-proliferative effects of Nodal in human trophoblast cells

Lubna Nadeem,Jelena Brkic,Yangchun Frank Chen,Tung Bui,Sadia Munir,Chun Peng

Abstract

View articletitled, Cytoplasmic mislocalization of p27 and CDK2 mediates the anti-migratory and anti-proliferative effects of Nodal in human trophoblast cells

Supplementary information

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HIV-1 Tat protein inhibits neurosecretion by binding to phosphatidylinositol 4,5-bisphosphate

Petra Tryoen-Tóth,Sylvette Chasserot-Golaz,Annie Tu,Patricia Gherib,Marie-France Bader,Bruno Beaumelle,Nicolas Vitale

Abstract

View articletitled, HIV-1 Tat protein inhibits neurosecretion by binding to phosphatidylinositol 4,5-bisphosphate

Supplementary information

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Positional editing of transmembrane domains during ion channel assembly

Karin Öjemalm,Helen R. Watson,Peristera Roboti,Benedict C. S. Cross,Jim Warwicker,Gunnar von Heijne,Stephen High

Abstract

View articletitled, Positional editing of transmembrane domains during ion channel assembly

Supplementary information

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Get3 is a holdase chaperone and moves to deposition sites for aggregated proteins when membrane targeting is blocked

Katie Powis,Bianca Schrul,Heather Tienson,Irina Gostimskaya,Michal Breker,Stephen High,Maya Schuldiner,Ursula Jakob,Blanche Schwappach

Abstract

View articletitled, Get3 is a holdase chaperone and moves to deposition sites for aggregated proteins when membrane targeting is blocked

Supplementary information

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Coordinate regulation of N-glycosylation gene DPAGT1, canonical Wnt signaling and E-cadherin adhesion

Pritam K. Sengupta,Meghan P. Bouchie,Mihai Nita-Lazar,Hsiao-Ying Yang,Maria A. Kukuruzinska

Abstract

View articletitled, Coordinate regulation of N-glycosylation gene DPAGT1, canonical Wnt signaling and E-cadherin adhesion

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Actin-regulated feedback loop based on Phactr4, PP1 and cofilin maintains the actin monomer pool

Guillaume Huet,Eeva Kaisa Rajakylä,Tiina Viita,Kari-Pekka Skarp,Marko Crivaro,Joseph Dopie,Maria K. Vartiainen

Abstract

View articletitled, Actin-regulated feedback loop based on Phactr4, PP1 and cofilin maintains the actin monomer pool

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N-terminal truncation of Lats1 causes abnormal cell growth control and chromosomal instability

Norikazu Yabuta,Satomi Mukai,Ayumi Okamoto,Daisuke Okuzaki,Hirokazu Suzuki,Kosuke Torigata,Kaori Yoshida,Nobuhiro Okada,Daisaku Miura,Akihiko Ito,Masahito Ikawa,Masaru Okabe,Hiroshi Nojima

Abstract

View articletitled, N-terminal truncation of Lats1 causes abnormal cell growth control and chromosomal instability

Supplementary information

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An intracellular membrane junction consisting of flagellum adhesion glycoproteins links flagellum biogenesis to cell morphogenesis in Trypanosoma brucei

Stella Y. Sun,Chao Wang,Y. Adam Yuan,Cynthia Y. He

Abstract

View articletitled, An intracellular membrane junction consisting of flagellum adhesion glycoproteins links flagellum biogenesis to cell morphogenesis in Trypanosoma brucei

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BMP9-regulated angiogenic signaling plays an important role in the osteogenic differentiation of mesenchymal progenitor cells

Ning Hu,Dianming Jiang,Enyi Huang,Xing Liu,Ruidong Li,Xi Liang,Stephanie H. Kim,Xiang Chen,Jian-Li Gao,Hongyu Zhang,Wenwen Zhang,Yu-Han Kong,Jiye Zhang,Jinhua Wang,Wei Shui,Xiaoji Luo,Bo Liu,Jing Cui,Mary Rose Rogers,Jikun Shen,Chen Zhao,Ning Wang,Ningning Wu,Hue H. Luu,Rex C. Haydon,Tong-Chuan He,Wei Huang

Abstract

View articletitled, BMP9-regulated angiogenic signaling plays an important role in the osteogenic differentiation of mesenchymal progenitor cells

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IPP5 inhibits neurite growth in primary sensory neurons by maintaining TGF-β/Smad signaling

Qing-Jian Han,Nan-Nan Gao,Guo-QiangMa,Zhen-Ning Zhang,Wen-Hui Yu,Jing Pan,Qiong Wang,Xu Zhang,Lan Bao

Abstract

View articletitled, IPP5 inhibits neurite growth in primary sensory neurons by maintaining TGF-β/Smad signaling

Supplementary information

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In tight junctions, claudins regulate the interactions between occludin, tricellulin and marvelD3, which, inversely, modulate claudin oligomerization

Jimmi Cording,Johanna Berg,Nadja Käding,Christian Bellmann,Christian Tscheik,Julie K. Westphal,Susanne Milatz,Dorothee Günzel,Hartwig Wolburg,Jörg Piontek,Otmar Huber,Ingolf Ernst Blasig

Abstract

View articletitled, In tight junctions, claudins regulate the interactions between occludin, tricellulin and marvelD3, which, inversely, modulate claudin oligomerization

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Ezh2 maintains a key phase of muscle satellite cell expansion but does not regulate terminal differentiation

Samuel Woodhouse,Dhamayanthi Pugazhendhi,Patrick Brien,Jennifer M. Pell

Abstract

View articletitled, Ezh2 maintains a key phase of muscle satellite cell expansion but does not regulate terminal differentiation

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Ubiquitin-independent function of optineurin in autophagic clearance of protein aggregates

Jelena Korac,Veronique Schaeffer,Igor Kovacevic,Albrecht M. Clement,Benno Jungblut,Christian Behl,Janos Terzic,Ivan Dikic

Abstract

View articletitled, Ubiquitin-independent function of optineurin in autophagic clearance of protein aggregates

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Atg18 function in autophagy is regulated by specific sites within its β-propeller

Ester Rieter,Fabian Vinke,Daniela Bakula,Eduardo Cebollero,Christian Ungermann,Tassula Proikas-Cezanne,Fulvio Reggiori

Abstract

View articletitled, Atg18 function in autophagy is regulated by specific sites within its β-propeller

Supplementary information

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Role of STIM1- and Orai1-mediated Ca²⁺ entry in Ca²⁺-induced epidermal keratinocyte differentiation

Takuro Numaga-Tomita,James W. Putney

Abstract

View articletitled, Role of STIM1- and Orai1-mediated Ca2+ entry in Ca2+-induced epidermal keratinocyte differentiation

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Regulation of fibroblast growth factor receptor signalling and trafficking by Src and Eps8

Giulio Auciello,Debbie L. Cunningham,Tulin Tatar,John K. Heath,Joshua Z. Rappoport

Abstract

View articletitled, Regulation of fibroblast growth factor receptor signalling and trafficking by Src and Eps8

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Nuclear ErbB4 signaling through H3K9me3 is antagonized by EGFR-activated c-Src

Kenichi Ishibashi,Yasunori Fukumoto,Hitomi Hasegawa,Kohei Abe,Shoichi Kubota,Kazumasa Aoyama,Sho Kubota,Yuji Nakayama,Naoto Yamaguchi

Abstract

View articletitled, Nuclear ErbB4 signaling through H3K9me3 is antagonized by EGFR-activated c-Src

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Specific roles of G_i protein family members revealed by dissecting SST5 coupling in human pituitary cells

Erika Peverelli,Marta Busnelli,Eleonora Vitali,Elena Giardino,Celine Galés,Andrea G. Lania,Paolo Beck-Peccoz,Bice Chini,Giovanna Mantovani,Anna Spada

Abstract

View articletitled, Specific roles of Gi protein family members revealed by dissecting SST5 coupling in human pituitary cells

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Activation of Notch in lgd mutant cells requires the fusion of late endosomes with the lysosome

Markus Schneider,Tobias Troost,Ferdi Grawe,Alfonso Martinez-Arias,Thomas Klein

Abstract

View articletitled, Activation of Notch in lgd mutant cells requires the fusion of late endosomes with the lysosome

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Protein tyrosine phosphatase SHP2 suppresses podosome rosette formation in Src-transformed fibroblasts

Yi-Ru Pan,Ke-Huan Cho,Hsiao-Hui Lee,Zee-Fen Chang,Hong-Chen Chen

Abstract

View articletitled, Protein tyrosine phosphatase SHP2 suppresses podosome rosette formation in Src-transformed fibroblasts

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Impairment of TRPC1–STIM1 channel assembly and AQP5 translocation compromise agonist-stimulated fluid secretion in mice lacking caveolin1

Biswaranjan Pani,Xibao Liu,Sunitha Bollimuntha,Kwong Tai Cheng,Ingrid R. Niesman,Changyu Zheng,Virginia R. Achen,Hemal H. Patel,Indu S. Ambudkar,Brij B. Singh

Abstract

View articletitled, Impairment of TRPC1–STIM1 channel assembly and AQP5 translocation compromise agonist-stimulated fluid secretion in mice lacking caveolin1

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Regulation of telomere length and homeostasis by telomerase enzyme processivity

Yasmin D'Souza,Catherine Lauzon,Tsz Wai Chu,Chantal Autexier

Abstract

View articletitled, Regulation of telomere length and homeostasis by telomerase enzyme processivity

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Plexin B1 inhibits MET through direct association and regulates Shp2 expression in melanocytes

Joanne Soong,Glynis Scott

Abstract

View articletitled, Plexin B1 inhibits MET through direct association and regulates Shp2 expression in melanocytes

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Role of Ser129 phosphorylation of α-synuclein in melanoma cells

Byung Rho Lee,Yasuhiro Matsuo,Anil G. Cashikar,Tetsu Kamitani

Abstract

View articletitled, Role of Ser129 phosphorylation of α-synuclein in melanoma cells

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IN THIS ISSUE

ARTICLE OF INTEREST IN OTHER COB JOURNALS

FROM DEVELOPMENT

Transmembrane/cytoplasmic, rather than catalytic, domains of Mmp14 signal to MAPK activation and mammary branching morphogenesis via binding to integrin β1

Hidetoshi Mori,Alvin T. Lo,Jamie L. Inman,Jordi Alcaraz,Cyrus M. Ghajar,Joni D. Mott,Celeste M. Nelson,Connie S. Chen,Hui Zhang,Jamie L. Bascom,Motoharu Seiki,Mina J. Bissell

View articletitled, Transmembrane/cytoplasmic, rather than catalytic, domains of Mmp14 signal to MAPK activation and mammary branching morphogenesis via binding to integrin β1

Type Ib BMP receptors mediate the rate of commissural axon extension through inhibition of cofilin activity

Ken Yamauchi,Supraja G. Varadarajan,Joseph E. Li,Samantha J. Butler

View articletitled, Type Ib BMP receptors mediate the rate of commissural axon extension through inhibition of cofilin activity

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Accepted manuscripts

Primary cilia shape postnatal astrocyte development through Sonic Hedgehog signaling

Rachel Bear, Steven A. Sloan, Tamara Caspary

Rab40 GTPases regulate AMBRA1-mediated transcription and cell migration

Revathi Sampath, Katherine Vaeth, Valeryia Mikalayeva, Vytenis Arvydas Skeberdis, Rytis Prekeris, Ke-Jun Han

Select autosomal dominant DFNA11 deafness mutations activate Myo7A targeting in epithelial cells

Prashun Acharya, Garima Thapa, Xiayi Liao, Samaneh Matoo, Maura J. Graves, Sarah Y. Atallah, Ashna K. Tipirneni, Tram Nguyen, Niki M. Chhabra, Jaden Maschack, Mackenzie R. Herod, Favour A. Ohaezu, Alder Robison, Ashwini Mudaliyar, Jasvinder Bharaj, Nicole Roeser, Katherine Holmes, Vishwaas Nayak, Rayah Alsayed, Benjamin J. Perrin, Scott W. Crawley

Definition of the human mitochondrial TOM interactome reveals TRABD as new interacting protein

Metin Özdemir, Silke Oeljeklaus, Schendzielorz Alexander, Marcel Morgenstern, Anusha Valpadashi, Roya Yousefi, Bettina Warscheid, Sven Dennerlein

The Mia40 substrate Mix17 exposes its N-terminus to the cytosolic side of the mitochondrial outer membrane

Moritz Resch, Johanna S. Frickel, Korbinian Dischinger, Rachel Choo Shen Wen, Kai Hell, Max E. Harner

More accepted manuscripts

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CELL SCIENCE AT A GLANCE

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ARTICLE OF INTEREST IN OTHER COB JOURNALS

FROM DEVELOPMENT

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