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Volume 125, Issue 24

December 2012

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Cover image

Cover Image

Cover: Transcripts encoding the Na⁺/K⁺-ATPase α₂-isoform (Atp1a2) are predominantly expressed in slow-twitch muscles, and not fast-twitch muscles, in zebrafish. The image represents a transverse section of a zebrafish embryo at 60-hours post-fertilization double-stained by in situ hybridization for Atp1a2 (red) in combination with immunostaining using anti-F310 antibody, which labels fast-twitch muscles (green). Image courtesy of Canan Doğanlı and Jakob Kibsgaard (Aarhus University). See article by Canan Doğanlı et al. (pp. 6166–6175).
Table of contents

ISSN 0021-9533

EISSN 1477-9137

In this issue

STICKY WICKET
CELL SCIENCE AT A GLANCE
COMMENTARY
SHORT REPORT
RESEARCH ARTICLE
CORRECTION
ARTICLE OF INTEREST IN OTHER COB JOURNALS
- FROM DEVELOPMENT
IN THIS ISSUE

STICKY WICKET

The end of science

MoleVIII

Extract

View articletitled, The end of science

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CELL SCIENCE AT A GLANCE

Caspase-2 at a glance

Luca L. Fava,Florian J. Bock,Stephan Geley,Andreas Villunger

Extract

View articletitled, Caspase-2 at a glance

Supplementary information

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COMMENTARY

At the leading edge of three-dimensional cell migration

Ryan J. Petrie,Kenneth M. Yamada

Abstract

View articletitled, At the leading edge of three-dimensional cell migration

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The KMN protein network – chief conductors of the kinetochore orchestra

Dileep Varma,E. D. Salmon

Abstract

View articletitled, The KMN protein network – chief conductors of the kinetochore orchestra

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SHORT REPORT

Mechanism of polarized lysosome exocytosis in epithelial cells

Jin Xu,Kimberly A. Toops,Fernando Diaz,Jose Maria Carvajal-Gonzalez,Diego Gravotta,Francesca Mazzoni,Ryan Schreiner,Enrique Rodriguez-Boulan,Aparna Lakkaraju

Abstract

View articletitled, Mechanism of polarized lysosome exocytosis in epithelial cells

Supplementary information

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Autocrine and paracrine unpaired signaling regulate intestinal stem cell maintenance and division

Dani Osman,Nicolas Buchon,Sveta Chakrabarti,Yu-Ting Huang,Wan-Chi Su,Mickaël Poidevin,Yu-Chen Tsai,Bruno Lemaitre

Abstract

View articletitled, Autocrine and paracrine unpaired signaling regulate intestinal stem cell maintenance and division

Supplementary information

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Involvement of the mRNA binding protein CRD-BP in the regulation of metastatic melanoma cell proliferation and invasion by hypoxia

Evisabel A. Craig,Jonathan D. Weber,Vladimir S. Spiegelman

Abstract

View articletitled, Involvement of the mRNA binding protein CRD-BP in the regulation of metastatic melanoma cell proliferation and invasion by hypoxia

Supplementary information

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Fission yeast TORC1 prevents eIF2α phosphorylation in response to nitrogen and amino acids via Gcn2 kinase

Noelia Valbuena,Ana Elisa Rozalén,Sergio Moreno

Abstract

View articletitled, Fission yeast TORC1 prevents eIF2α phosphorylation in response to nitrogen and amino acids via Gcn2 kinase

Supplementary information

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RESEARCH ARTICLE

Tetraspan TM4SF5-dependent direct activation of FAK and metastatic potential of hepatocarcinoma cells

Oisun Jung,Suyong Choi,Sun-Bok Jang,Sin-Ae Lee,Ssang-Taek Lim,Yoon-Ju Choi,Hye-Jin Kim,Do-Hee Kim,Tae Kyoung Kwak,Hyeonjung Kim,Minkyung Kang,Mi-Sook Lee,Sook Young Park,Jihye Ryu,Doyoung Jeong,Hae-Kap Cheong,Hyun Jeong Kim,Ki Hun Park,Bong-Jin Lee,David D. Schlaepfer,Jung Weon Lee

Abstract

View articletitled, Tetraspan TM4SF5-dependent direct activation of FAK and metastatic potential of hepatocarcinoma cells

Supplementary information

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Matrix stiffness reverses the effect of actomyosin tension on cell proliferation

Justin D. Mih,Aleksandar Marinkovic,Fei Liu,Asma S. Sharif,Daniel J. Tschumperlin

Abstract

View articletitled, Matrix stiffness reverses the effect of actomyosin tension on cell proliferation

Supplementary information

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Drosophila embryos close epithelial wounds using a combination of cellular protrusions and an actomyosin purse string

Maria Teresa Abreu-Blanco,Jeffrey M. Verboon,Raymond Liu,James J. Watts,Susan M. Parkhurst

Abstract

View articletitled, Drosophila embryos close epithelial wounds using a combination of cellular protrusions and an actomyosin purse string

Supplementary information

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Tubulin detyrosination promotes monolayer formation and apical trafficking in epithelial cells

Sabrina Zink,Lena Grosse,Andrea Freikamp,Sebastian Bänfer,Frauke Müksch,Ralf Jacob

Abstract

View articletitled, Tubulin detyrosination promotes monolayer formation and apical trafficking in epithelial cells

Supplementary information

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The Hippo pathway member Yap plays a key role in influencing fate decisions in muscle satellite cells

Robert N. Judson,Annie M. Tremblay,Paul Knopp,Robert B. White,Roby Urcia,Cosimo De Bari,Peter S. Zammit,Fernando D. Camargo,Henning Wackerhage

Abstract

View articletitled, The Hippo pathway member Yap plays a key role in influencing fate decisions in muscle satellite cells

Supplementary information

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The motor protein myosin 1G functions in FcγR-mediated phagocytosis

Anna E. Dart,Sylvain Tollis,Michael D. Bright,Gad Frankel,Robert G. Endres

Abstract

View articletitled, The motor protein myosin 1G functions in FcγR-mediated phagocytosis

Supplementary information

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The APC activator fizzy-related-1 (FZR1) is needed for preimplantation mouse embryo development

Michelle K. Y. Seah,Janet E. Holt,Irene García-Higuera,Sergio Moreno,Keith T. Jones

Abstract

View articletitled, The APC activator fizzy-related-1 (FZR1) is needed for preimplantation mouse embryo development

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Microsomal triacylglycerol transfer protein (MTP) is required to expand tracheal lumen in Drosophila in a cell-autonomous manner

Magdalena M. Baer,Wilhelm Palm,Suzanne Eaton,Maria Leptin,Markus Affolter

Abstract

View articletitled, Microsomal triacylglycerol transfer protein (MTP) is required to expand tracheal lumen in Drosophila in a cell-autonomous manner

Supplementary information

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MDC1 and RNF8 function in a pathway that directs BRCA1-dependent localization of PALB2 required for homologous recombination

Fan Zhang,Gregory Bick,Jung-Young Park,Paul R. Andreassen

Abstract

View articletitled, MDC1 and RNF8 function in a pathway that directs BRCA1-dependent localization of PALB2 required for homologous recombination

Supplementary information

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Fibroblast growth factor homologous factor 1 interacts with NEMO to regulate NF-κB signaling in neurons

Hans-Georg König,Beau J. Fenner,Jennifer C. Byrne,Robert F. Schwamborn,Tytus Bernas,Caroline A. Jefferies,Jochen H. M. Prehn

Abstract

View articletitled, Fibroblast growth factor homologous factor 1 interacts with NEMO to regulate NF-κB signaling in neurons

Supplementary information

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Shox2 regulates progression through chondrogenesis in the mouse proximal limb

Brent E. Bobick,John Cobb

Abstract

View articletitled, Shox2 regulates progression through chondrogenesis in the mouse proximal limb

Supplementary information

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Antibodies binding the ADAM10 substrate recognition domain inhibit Eph function

Lakmali Atapattu,Nayanendu Saha,Carmen Llerena,Mary E. Vail,Andrew M. Scott,Dimitar B. Nikolov,Martin Lackmann,Peter W. Janes

Abstract

View articletitled, Antibodies binding the ADAM10 substrate recognition domain inhibit Eph function

Supplementary information

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Histone variant macroH2A marks embryonic differentiation in vivo and acts as an epigenetic barrier to induced pluripotency

Vincent Pasque,Aliaksandra Radzisheuskaya,Astrid Gillich,Richard P. Halley-Stott,Maryna Panamarova,Magdalena Zernicka-Goetz,M. Azim Surani,José C. R. Silva

Abstract

View articletitled, Histone variant macroH2A marks embryonic differentiation in vivo and acts as an epigenetic barrier to induced pluripotency

Supplementary information

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The conserved P body component HPat/Pat1 negatively regulates synaptic terminal growth at the larval Drosophila neuromuscular junction

Sarala J. Pradhan,Katherine R. Nesler,Sarah F. Rosen,Yasuko Kato,Akira Nakamura,Mani Ramaswami,Scott A. Barbee

Abstract

View articletitled, The conserved P body component HPat/Pat1 negatively regulates synaptic terminal growth at the larval Drosophila neuromuscular junction

Supplementary information

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Hypoxia induces downregulation of soluble guanylyl cyclase β₁ by miR-34c-5p

Xiaojian Xu,Shumin Wang,Juan Liu,Dou Dou,Limei Liu,Zhengju Chen,Liping Ye,Huixia Liu,Qiong He,J. Usha Raj,Yuansheng Gao

Abstract

View articletitled, Hypoxia induces downregulation of soluble guanylyl cyclase β1 by miR-34c-5p

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Active involvement of micro-lipid droplets and lipid-droplet-associated proteins in hormone-stimulated lipolysis in adipocytes

Takeshi Hashimoto,Hiroki Segawa,Masanari Okuno,Hideaki Kano,Hiro-o Hamaguchi,Tokuko Haraguchi,Yasushi Hiraoka,Shiho Hasui,Tomohiro Yamaguchi,Fumiko Hirose,Takashi Osumi

Abstract

View articletitled, Active involvement of micro-lipid droplets and lipid-droplet-associated proteins in hormone-stimulated lipolysis in adipocytes

Supplementary information

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Nuclear Na⁺/K⁺-ATPase plays an active role in nucleoplasmic Ca²⁺ homeostasis

Charitha Galva,Pablo Artigas,Craig Gatto

Abstract

View articletitled, Nuclear Na+/K+-ATPase plays an active role in nucleoplasmic Ca2+ homeostasis

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Glutathione peroxidase 3, a new retinoid target gene, is crucial for human skeletal muscle precursor cell survival

Marina El Haddad,Elise Jean,Ahmed Turki,Gérald Hugon,Barbara Vernus,Anne Bonnieu,Emilie Passerieux,Aline Hamade,Jacques Mercier,Dalila Laoudj-Chenivesse,Gilles Carnac

Abstract

View articletitled, Glutathione peroxidase 3, a new retinoid target gene, is crucial for human skeletal muscle precursor cell survival

Supplementary information

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The functions of anionic phospholipids during clathrin-mediated endocytosis site initiation and vesicle formation

Yidi Sun,David G. Drubin

Abstract

View articletitled, The functions of anionic phospholipids during clathrin-mediated endocytosis site initiation and vesicle formation

Supplementary information

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The α₂Na⁺/K⁺-ATPase is critical for skeletal and heart muscle function in zebrafish

Canan Doğanlı,Kasper Kjaer-Sorensen,Christopher Knoeckel,Hans Christian Beck,Jens Randel Nyengaard,Bent Honoré,Poul Nissen,Angeles Ribera,Claus Oxvig,Karin Lykke-Hartmann

Abstract

View articletitled, The α2Na+/K+-ATPase is critical for skeletal and heart muscle function in zebrafish

Supplementary information

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Dual targeting of aminoacyl-tRNA synthetases to the mitochondrion and complex plastid in chlorarachniophytes

Yoshihisa Hirakawa,Fabien Burki,Patrick J. Keeling

Abstract

View articletitled, Dual targeting of aminoacyl-tRNA synthetases to the mitochondrion and complex plastid in chlorarachniophytes

Supplementary information

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Src binds cortactin through an SH2 domain cystine-mediated linkage

Jason V. Evans,Amanda G. Ammer,John E. Jett,Chris A. Bolcato,Jason C. Breaux,Karen H. Martin,Mark V. Culp,Peter M. Gannett,Scott A. Weed

Abstract

View articletitled, Src binds cortactin through an SH2 domain cystine-mediated linkage

Supplementary information

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CORRECTION

Myf5 haploinsufficiency reveals distinct cell fate potentials for adult skeletal muscle stem cells

Barbara Gayraud-Morel,Fabrice Chrétien,Aurélie Jory,Ramkumar Sambasivan,Elisa Negroni,Patricia Flamant,Guillaume Soubigou,Jean-Yves Coppée,James Di Santo,Ana Cumano,Vincent Mouly,Shahragim Tajbakhsh

Extract

View articletitled, Myf5 haploinsufficiency reveals distinct cell fate potentials for adult skeletal muscle stem cells

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ARTICLE OF INTEREST IN OTHER COB JOURNALS

FROM DEVELOPMENT

Residual body removal during spermatogenesis in C. elegans requires genes that mediate cell corpse clearance

Jie Huang,Haibin Wang,Yingyu Chen,Xiaochen Wang,Hong Zhang

View articletitled, Residual body removal during spermatogenesis in C. elegans requires genes that mediate cell corpse clearance

Tissue-specific function of Patj in regulating the Crumbs complex and epithelial polarity

Clothilde Pénalva,Vincent Mirouse

View articletitled, Tissue-specific function of Patj in regulating the Crumbs complex and epithelial polarity

IN THIS ISSUE

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Accepted manuscripts

Centrosome amplification promotes cell invasion via cell-cell contact disruption and Rap-1 activation

Anu Prakash, Shishir Paunikar, Mark Webber, Emma McDermott, Sri H. Vellanki, Kerry Thompson, Peter Dockery, Hanne Jahns, James A. L. Brown, Ann M. Hopkins, Emer Bourke

Time-resolved proximity biotinylation implicates a porin protein in export of transmembrane malaria parasite effectors

David Anaguano, Watcharatip Dedkhad, Carrie F. Brooks, David W. Cobb, Vasant Muralidharan

Light Activated BioID (LAB): an optically activated proximity labeling system to study protein-protein interactions

Omer Shafraz, Carolyn Marie Orduno Davis, Sanjeevi Sivasankar

Transcription inhibition suppresses nuclear blebbing and rupture independent of nuclear rigidity

Isabel K. Berg, Marilena L. Currey, Sarthak Gupta, Yasmin Berrada, Bao V. Nguyen, Mai Pho, Alison E. Patteson, J. M. Schwarz, Edward J. Banigan, Andrew D. Stephens

Key role for Rac in the early transcriptional response to ECM stiffness and the stiffness-dependent repression of ATF3

Irène Dang, Joseph A. Brazzo, Yongho Bae, Richard K. Assoian

More accepted manuscripts

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STICKY WICKET

CELL SCIENCE AT A GLANCE

COMMENTARY

SHORT REPORT

RESEARCH ARTICLE

CORRECTION

ARTICLE OF INTEREST IN OTHER COB JOURNALS

FROM DEVELOPMENT

IN THIS ISSUE

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