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Volume 125, Issue 22

November 2012

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Cover image

Cover Image

Cover: Newborn rat hippocampal neuron with neurites extended in culture. Purple colour indicates the localization of the α7 nicotinic receptor within the primary axon and growth cone. See article by J. C. Nordman and N. Kabbani (pp. 5502–5513).
Table of contents

ISSN 0021-9533

EISSN 1477-9137

In this issue

CELL SCIENCE AT A GLANCE
CELL SCIENCE IN CONTEXT
COMMENTARY
RESEARCH ARTICLE
ERRATUM
ARTICLE OF INTEREST IN OTHER COB JOURNALS
- FROM DEVELOPMENT
IN THIS ISSUE

CELL SCIENCE AT A GLANCE

Diversity in unconventional protein secretion

Catherine Rabouille,Vivek Malhotra,Walter Nickel

Extract

View articletitled, Diversity in unconventional protein secretion

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CELL SCIENCE IN CONTEXT

Keratin intermediate filament proteins – novel regulators of inflammation and immunity in skin

Ryan P. Hobbs,Juliane C. Lessard,Pierre A. Coulombe

Extract

View articletitled, Keratin intermediate filament proteins – novel regulators of inflammation and immunity in skin

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COMMENTARY

Life in the balance – a mechanistic view of the crosstalk between autophagy and apoptosis

Assaf D. Rubinstein,Adi Kimchi

Abstract

View articletitled, Life in the balance – a mechanistic view of the crosstalk between autophagy and apoptosis

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RESEARCH ARTICLE

Keratin 1 maintains skin integrity and participates in an inflammatory network in skin through interleukin-18

Wera Roth,Vinod Kumar,Hans-Dietmar Beer,Miriam Richter,Claudia Wohlenberg,Ursula Reuter,Sören Thiering,Andrea Staratschek-Jox,Andrea Hofmann,Fatima Kreusch,Joachim L. Schultze,Thomas Vogl,Johannes Roth,Julia Reichelt,Ingrid Hausser,Thomas M. Magin

Abstract

View articletitled, Keratin 1 maintains skin integrity and participates in an inflammatory network in skin through interleukin-18

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Unrepairable DNA double-strand breaks that are generated by ionising radiation determine the fate of normal human cells

Asao Noda,Yuko Hirai,Kanya Hamasaki,Hiroshi Mitani,Nori Nakamura,Yoshiaki Kodama

Abstract

View articletitled, Unrepairable DNA double-strand breaks that are generated by ionising radiation determine the fate of normal human cells

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Upon Wnt stimulation, Rac1 activation requires Rac1 and Vav2 binding to p120-catenin

Gabriela Valls,Montserrat Codina,Rachel K. Miller,Beatriz Del Valle-Pérez,Meritxell Vinyoles,Carme Caelles,Pierre D. McCrea,Antonio García de Herreros,Mireia Duñach

Abstract

View articletitled, Upon Wnt stimulation, Rac1 activation requires Rac1 and Vav2 binding to p120-catenin

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Mechanism and function of Vav1 localisation in TCR signalling

Olga Ksionda,Alexander Saveliev,Robert Köchl,Jonathan Rapley,Mustapha Faroudi,Jennifer E. Smith-Garvin,Christoph Wülfing,Katrin Rittinger,Tom Carter,Victor L. J. Tybulewicz

Abstract

View articletitled, Mechanism and function of Vav1 localisation in TCR signalling

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Microdomains of muscarinic acetylcholine and Ins(1,4,5)P₃ receptors create ‘Ins(1,4,5)P₃ junctions’ and sites of Ca²⁺ wave initiation in smooth muscle

Marnie L. Olson,Mairi E. Sandison,Susan Chalmers,John G. McCarron

Abstract

View articletitled, Microdomains of muscarinic acetylcholine and Ins(1,4,5)P3 receptors create ‘Ins(1,4,5)P3 junctions’ and sites of Ca2+ wave initiation in smooth muscle

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Foxk1 promotes cell proliferation and represses myogenic differentiation by regulating Foxo4 and Mef2

Xiaozhong Shi,Alicia M. Wallis,Robert D. Gerard,Kevin A. Voelker,Robert W. Grange,Ronald A. DePinho,Mary G. Garry,Daniel J. Garry

Abstract

View articletitled, Foxk1 promotes cell proliferation and represses myogenic differentiation by regulating Foxo4 and Mef2

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Focal adhesion disassembly is regulated by a RIAM to MEK-1 pathway

Georgina P. Coló,Pablo Hernández-Varas,John Lock,Rubén A. Bartolomé,Nohemí Arellano-Sánchez,Staffan Strömblad,Joaquin Teixidó

Abstract

View articletitled, Focal adhesion disassembly is regulated by a RIAM to MEK-1 pathway

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Oscillation of APC/C activity during cell cycle arrest promotes centrosome amplification

Suzanna L. Prosser,Mugdha D. Samant,Joanne E. Baxter,Ciaran G. Morrison,Andrew M. Fry

Abstract

View articletitled, Oscillation of APC/C activity during cell cycle arrest promotes centrosome amplification

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Depletion of histone deacetylase 3 antagonizes PI3K-mediated overgrowth of Drosophila organs through the acetylation of histone H4 at lysine 16

Wen-Wen Lv,Hui-Min Wei,Da-Liang Wang,Jian-Quan Ni,Fang-Lin Sun

Abstract

View articletitled, Depletion of histone deacetylase 3 antagonizes PI3K-mediated overgrowth of Drosophila organs through the acetylation of histone H4 at lysine 16

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RAC1 in keratinocytes regulates crosstalk to immune cells by Arp2/3-dependent control of STAT1

Esben Pedersen,Zhipeng Wang,Alanna Stanley,Karine Peyrollier,Lennart M. Rösner,Thomas Werfel,Fabio Quondamatteo,Cord Brakebusch

Abstract

View articletitled, RAC1 in keratinocytes regulates crosstalk to immune cells by Arp2/3-dependent control of STAT1

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Acentrosomal spindle organization renders cancer cells dependent on the kinesin HSET

Julia Kleylein-Sohn,Bernadette Pöllinger,Michaela Ohmer,Francesco Hofmann,Erich A. Nigg,Brian A. Hemmings,Markus Wartmann

Abstract

View articletitled, Acentrosomal spindle organization renders cancer cells dependent on the kinesin HSET

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Division of the intermediate compartment at the onset of mitosis provides a mechanism for Golgi inheritance

Michaël Marie,Hege A. Dale,Nina Kouprina,Jaakko Saraste

Abstract

View articletitled, Division of the intermediate compartment at the onset of mitosis provides a mechanism for Golgi inheritance

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The doublecortin-related gene zyg-8 is a microtubule organizer in Caenorhabditis elegans neurons

Jean-Michel Bellanger,Juan G. Cueva,Renee Baran,Garland Tang,Miriam B. Goodman,Anne Debant

Abstract

View articletitled, The doublecortin-related gene zyg-8 is a microtubule organizer in Caenorhabditis elegans neurons

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Vimentin and the K-Ras-induced actin-binding protein control inositol-(1,4,5)-trisphosphate receptor redistribution during MDCK cell differentiation

Florent Dingli,Jan B. Parys,Damarys Loew,Simon Saule,Laurence Mery

Abstract

View articletitled, Vimentin and the K-Ras-induced actin-binding protein control inositol-(1,4,5)-trisphosphate receptor redistribution during MDCK cell differentiation

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Mutations in Cog7 affect Golgi structure, meiotic cytokinesis and sperm development during Drosophila spermatogenesis

Giorgio Belloni,Stefano Sechi,Maria Giovanna Riparbelli,Margaret T. Fuller,Giuliano Callaini,Maria Grazia Giansanti

Abstract

View articletitled, Mutations in Cog7 affect Golgi structure, meiotic cytokinesis and sperm development during Drosophila spermatogenesis

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Inn1 and Cyk3 regulate chitin synthase during cytokinesis in budding yeasts

Asli Devrekanli,Magdalena Foltman,Cesar Roncero,Alberto Sanchez-Diaz,Karim Labib

Abstract

View articletitled, Inn1 and Cyk3 regulate chitin synthase during cytokinesis in budding yeasts

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CXCL12 receptor preference, signal transduction, biological response and the expression of 5T4 oncofoetal glycoprotein

Owen J. McGinn,Georgi Marinov,Saladin Sawan,Peter L. Stern

Abstract

View articletitled, CXCL12 receptor preference, signal transduction, biological response and the expression of 5T4 oncofoetal glycoprotein

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Intracellular chloride channel protein CLIC1 regulates macrophage function through modulation of phagosomal acidification

Lele Jiang,Kanin Salao,Hui Li,Joanna M. Rybicka,Robin M. Yates,Xu Wei Luo,Xin Xin Shi,Tamara Kuffner,Vicky Wang-Wei Tsai,Yasmin Husaini,Liyun Wu,David A. Brown,Thomas Grewal,Louise J. Brown,Paul M. G. Curmi,Samuel N. Breit

Abstract

View articletitled, Intracellular chloride channel protein CLIC1 regulates macrophage function through modulation of phagosomal acidification

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Single-cell analysis of Daxx and ATRX-dependent transcriptional repression

Alyshia Newhart,Ilona U. Rafalska-Metcalf,Tian Yang,Dmitri G. Negorev,Susan M. Janicki

Abstract

View articletitled, Single-cell analysis of Daxx and ATRX-dependent transcriptional repression

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An interaction between α7 nicotinic receptors and a G-protein pathway complex regulates neurite growth in neural cells

Jacob C. Nordman,Nadine Kabbani

Abstract

View articletitled, An interaction between α7 nicotinic receptors and a G-protein pathway complex regulates neurite growth in neural cells

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The ATP permeability of pannexin 1 channels in a heterologous system and in mammalian taste cells is dispensable

Roman A. Romanov,Marina F. Bystrova,Olga A. Rogachevskaya,Vladimir B. Sadovnikov,Valery I. Shestopalov,Stanislav S. Kolesnikov

Abstract

View articletitled, The ATP permeability of pannexin 1 channels in a heterologous system and in mammalian taste cells is dispensable

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The SNF2 family ATPase LSH promotes phosphorylation of H2AX and efficient repair of DNA double-strand breaks in mammalian cells

Joe Burrage,Ausma Termanis,Andreas Geissner,Kevin Myant,Katrina Gordon,Irina Stancheva

Abstract

View articletitled, The SNF2 family ATPase LSH promotes phosphorylation of H2AX and efficient repair of DNA double-strand breaks in mammalian cells

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Macrophages require Skap2 and Sirpα for integrin-stimulated cytoskeletal rearrangement

Francis J. Alenghat,Quentin J. Baca,Nooreen T. Rubin,Lily I. Pao,Takashi Matozaki,Clifford A. Lowell,David E. Golan,Benjamin G. Neel,Kenneth D. Swanson

Abstract

View articletitled, Macrophages require Skap2 and Sirpα for integrin-stimulated cytoskeletal rearrangement

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Apical targeting and endocytosis of the sialomucin endolyn are essential for establishment of zebrafish pronephric kidney function

Di Mo,Gudrun Ihrke,Simone A. Costa,Lauren Brilli,Anatália Labilloy,Willi Halfter,Chiara Cianciolo Cosentino,Neil A. Hukriede,Ora A. Weisz

Abstract

View articletitled, Apical targeting and endocytosis of the sialomucin endolyn are essential for establishment of zebrafish pronephric kidney function

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Cyclin G is involved in meiotic recombination repair in Drosophila melanogaster

Anja C. Nagel,Patrick Fischer,Jutta Szawinski,Martina K. La Rosa,Anette Preiss

Abstract

View articletitled, Cyclin G is involved in meiotic recombination repair in Drosophila melanogaster

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NO–β-catenin crosstalk modulates primitive streak formation prior to embryonic stem cell osteogenic differentiation

Huawen Ding,Kevin C. Keller,Ivann K. C. Martinez,Rose M. Geransar,Kai O. zur Nieden,Sandra G. Nishikawa,Derrick E. Rancourt,Nicole I. zur Nieden

Abstract

View articletitled, NO–β-catenin crosstalk modulates primitive streak formation prior to embryonic stem cell osteogenic differentiation

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Mutant p53^R273H attenuates the expression of phase 2 detoxifying enzymes and promotes the survival of cells with high levels of reactive oxygen species

Eyal Kalo,Ira Kogan-Sakin,Hilla Solomon,Elad Bar-Nathan,Moshe Shay,Yoav Shetzer,Elya Dekel,Naomi Goldfinger,Yossi Buganim,Perry Stambolsky,Ido Goldstein,Shalom Madar,Varda Rotter

Abstract

View articletitled, Mutant p53R273H attenuates the expression of phase 2 detoxifying enzymes and promotes the survival of cells with high levels of reactive oxygen species

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ERRATUM

Filopodium retraction is controlled by adhesion to its tip

Stephane Romero,Alessia Quatela,Thomas Bornschlögl,Stéphanie Guadagnini,Patricia Bassereau,Guy Tran Van Nhieu

Extract

View articletitled, Filopodium retraction is controlled by adhesion to its tip

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ARTICLE OF INTEREST IN OTHER COB JOURNALS

FROM DEVELOPMENT

Wapl antagonizes cohesin binding and promotes Polycomb-group silencing in Drosophila

Melissa D. Cunningham,Maria Gause,Yuzhong Cheng,Amanda Noyes,Dale Dorsett,James A. Kennison,Judith A Kassis

View articletitled, Wapl antagonizes cohesin binding and promotes Polycomb-group silencing in Drosophila

Glypicans regulate JAK/STAT signaling and distribution of the Unpaired morphogen

Yoshiki Hayashi,Travis R. Sexton,Katsufumi Dejima,Dustin W. Perry,Masahiko Takemura,Satoru Kobayashi,Hiroshi Nakato,Douglas A. Harrison

View articletitled, Glypicans regulate JAK/STAT signaling and distribution of the Unpaired morphogen

IN THIS ISSUE

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Accepted manuscripts

Primary cilia shape postnatal astrocyte development through Sonic Hedgehog signaling

Rachel Bear, Steven A. Sloan, Tamara Caspary

Rab40 GTPases regulate AMBRA1-mediated transcription and cell migration

Revathi Sampath, Katherine Vaeth, Valeryia Mikalayeva, Vytenis Arvydas Skeberdis, Rytis Prekeris, Ke-Jun Han

Select autosomal dominant DFNA11 deafness mutations activate Myo7A targeting in epithelial cells

Prashun Acharya, Garima Thapa, Xiayi Liao, Samaneh Matoo, Maura J. Graves, Sarah Y. Atallah, Ashna K. Tipirneni, Tram Nguyen, Niki M. Chhabra, Jaden Maschack, Mackenzie R. Herod, Favour A. Ohaezu, Alder Robison, Ashwini Mudaliyar, Jasvinder Bharaj, Nicole Roeser, Katherine Holmes, Vishwaas Nayak, Rayah Alsayed, Benjamin J. Perrin, Scott W. Crawley

Definition of the human mitochondrial TOM interactome reveals TRABD as new interacting protein

Metin Özdemir, Silke Oeljeklaus, Schendzielorz Alexander, Marcel Morgenstern, Anusha Valpadashi, Roya Yousefi, Bettina Warscheid, Sven Dennerlein

The Mia40 substrate Mix17 exposes its N-terminus to the cytosolic side of the mitochondrial outer membrane

Moritz Resch, Johanna S. Frickel, Korbinian Dischinger, Rachel Choo Shen Wen, Kai Hell, Max E. Harner

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CELL SCIENCE AT A GLANCE

CELL SCIENCE IN CONTEXT

COMMENTARY

RESEARCH ARTICLE

ERRATUM

ARTICLE OF INTEREST IN OTHER COB JOURNALS

FROM DEVELOPMENT

IN THIS ISSUE

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