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Volume 125, Issue 21

November 2012

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Cover image

Cover Image

Cover: Fluorescence microscopy images for integrin binding (green) to fibronectin (red) adhesive clusters with different geometrical configurations. Nanopatterning of fibronectin islands reveals a nanoscale area threshold below which no stable integrin–fibronectin clusters are formed. Nanoisland area, and not the number of nanoislands or total adhesive area, controlled integrin–fibronectin clustering and force generation. See article by S. R. Coyer et al. (pp. 5110–5123).
Table of contents

ISSN 0021-9533

EISSN 1477-9137

In this issue

CELL SCIENCE AT A GLANCE
COMMENTARY
SHORT REPORT
RESEARCH ARTICLE
ARTICLE OF INTEREST IN OTHER COB JOURNALS
- FROM DEVELOPMENT
IN THIS ISSUE

CELL SCIENCE AT A GLANCE

Nuclear actin and myosins at a glance

Primal de Lanerolle

Extract

View articletitled, Nuclear actin and myosins at a glance

Supplementary information

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COMMENTARY

Centrosome positioning in vertebrate development

Nan Tang,Wallace F. Marshall

Abstract

View articletitled, Centrosome positioning in vertebrate development

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PGC1α and mitochondrial metabolism – emerging concepts and relevance in ageing and neurodegenerative disorders

Shane Austin,Julie St-Pierre

Abstract

View articletitled, PGC1α and mitochondrial metabolism – emerging concepts and relevance in ageing and neurodegenerative disorders

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SHORT REPORT

The SH2-domain-containing inositol 5-phosphatase (SHIP) limits the motility of neutrophils and their recruitment to wounds in zebrafish

Pui-ying Lam,Sa Kan Yoo,Julie M. Green,Anna Huttenlocher

Abstract

View articletitled, The SH2-domain-containing inositol 5-phosphatase (SHIP) limits the motility of neutrophils and their recruitment to wounds in zebrafish

Supplementary information

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Karyopherin-independent spontaneous transport of amphiphilic proteins through the nuclear pore

Masahiro Kumeta,Hideki Yamaguchi,Shige H. Yoshimura,Kunio Takeyasu

Abstract

View articletitled, Karyopherin-independent spontaneous transport of amphiphilic proteins through the nuclear pore

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Visualization of the moment of mouse sperm–egg fusion and dynamic localization of IZUMO1

Yuhkoh Satouh,Naokazu Inoue,Masahito Ikawa,Masaru Okabe

Abstract

View articletitled, Visualization of the moment of mouse sperm–egg fusion and dynamic localization of IZUMO1

Supplementary information

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Anoctamins are a family of Ca²⁺-activated Cl⁻ channels

Yuemin Tian,Rainer Schreiber,Karl Kunzelmann

Abstract

View articletitled, Anoctamins are a family of Ca2+-activated Cl− channels

Supplementary information

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Filopodium retraction is controlled by adhesion to its tip

Stephane Romero,Alessia Quatela,Thomas Bornschlögl,Stéphanie Guadagnini,Patricia Bassereau,Guy Tran Van Nhieu

Abstract

View articletitled, Filopodium retraction is controlled by adhesion to its tip

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RESEARCH ARTICLE

Cingulin is dispensable for epithelial barrier function and tight junction structure, and plays a role in the control of claudin-2 expression and response to duodenal mucosa injury

Laurent Guillemot,Yann Schneider,Paola Brun,Ignazio Castagliuolo,Daniela Pizzuti,Diego Martines,Lionel Jond,Massimo Bongiovanni,Sandra Citi

Abstract

View articletitled, Cingulin is dispensable for epithelial barrier function and tight junction structure, and plays a role in the control of claudin-2 expression and response to duodenal mucosa injury

Supplementary information

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SDF and GABA interact to regulate axophilic migration of GnRH neurons

Filippo Casoni,B. Ian Hutchins,Duncan Donohue,Michele Fornaro,Brian G. Condie,Susan Wray

Abstract

View articletitled, SDF and GABA interact to regulate axophilic migration of GnRH neurons

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Optineurin mediates a negative regulation of Rab8 by the GTPase-activating protein TBC1D17

Vipul Vaibhava,Ananthamurthy Nagabhushana,Madhavi Latha Somaraju Chalasani,Cherukuri Sudhakar,Asha Kumari,Ghanshyam Swarup

Abstract

View articletitled, Optineurin mediates a negative regulation of Rab8 by the GTPase-activating protein TBC1D17

Supplementary information

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GTF2IRD2 from the Williams–Beuren critical region encodes a mobile-element-derived fusion protein that antagonizes the action of its related family members

Stephen J. Palmer,Kylie M. Taylor,Nicole Santucci,Jocelyn Widagdo,Yee-Ka Agnes Chan,Jen-Li Yeo,Merritt Adams,Peter W. Gunning,Edna C. Hardeman

Abstract

View articletitled, GTF2IRD2 from the Williams–Beuren critical region encodes a mobile-element-derived fusion protein that antagonizes the action of its related family members

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Autocrine regulation of TGF-β1-induced cell migration by exocytosis of ATP and activation of P2 receptors in human lung cancer cells

Erina Takai,Mitsutoshi Tsukimoto,Hitoshi Harada,Keisuke Sawada,Yoshinori Moriyama,Shuji Kojima

Abstract

View articletitled, Autocrine regulation of TGF-β1-induced cell migration by exocytosis of ATP and activation of P2 receptors in human lung cancer cells

Supplementary information

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Polo-like kinase is required for synaptonemal complex disassembly and phosphorylation in mouse spermatocytes

Philip W. Jordan,Jesse Karppinen,Mary A. Handel

Abstract

View articletitled, Polo-like kinase is required for synaptonemal complex disassembly and phosphorylation in mouse spermatocytes

Supplementary information

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Arsenite interferes with protein folding and triggers formation of protein aggregates in yeast

Therese Jacobson,Clara Navarrete,Sandeep K. Sharma,Theodora C. Sideri,Sebastian Ibstedt,Smriti Priya,Chris M. Grant,Philipp Christen,Pierre Goloubinoff,Markus J. Tamás

Abstract

View articletitled, Arsenite interferes with protein folding and triggers formation of protein aggregates in yeast

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Role of phosphodiesterases in the shaping of sub-plasma-membrane cAMP oscillations and pulsatile insulin secretion

Geng Tian,Jenny Sågetorp,Yunjian Xu,Hongyan Shuai,Eva Degerman,Anders Tengholm

Abstract

View articletitled, Role of phosphodiesterases in the shaping of sub-plasma-membrane cAMP oscillations and pulsatile insulin secretion

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WD40-repeat protein 62 is a JNK-phosphorylated spindle pole protein required for spindle maintenance and timely mitotic progression

Marie A. Bogoyevitch,Yvonne Y. C. Yeap,Zhengdong Qu,Kevin R. Ngoei,Yan Y. Yip,Teresa T. Zhao,Julian I. Heng,Dominic C. H. Ng

Abstract

View articletitled, WD40-repeat protein 62 is a JNK-phosphorylated spindle pole protein required for spindle maintenance and timely mitotic progression

Supplementary information

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Nanopatterning reveals an ECM area threshold for focal adhesion assembly and force transmission that is regulated by integrin activation and cytoskeleton tension

Sean R. Coyer,Ankur Singh,David W. Dumbauld,David A. Calderwood,Susan W. Craig,Emmanuel Delamarche,Andrés J. García

Abstract

View articletitled, Nanopatterning reveals an ECM area threshold for focal adhesion assembly and force transmission that is regulated by integrin activation and cytoskeleton tension

Supplementary information

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Deregulated Cdk5 triggers aberrant activation of cell cycle kinases and phosphatases inducing neuronal death

Kuei-Hua Chang,Fabien Vincent,Kavita Shah

Abstract

View articletitled, Deregulated Cdk5 triggers aberrant activation of cell cycle kinases and phosphatases inducing neuronal death

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Modeling the self-organized phosphatidylinositol lipid signaling system in chemotactic cells using quantitative image analysis

Tatsuo Shibata,Masatoshi Nishikawa,Satomi Matsuoka,Masahiro Ueda

Abstract

View articletitled, Modeling the self-organized phosphatidylinositol lipid signaling system in chemotactic cells using quantitative image analysis

Supplementary information

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ATP inhibits Ins(1,4,5)P₃-evoked Ca²⁺ release in smooth muscle via P2Y₁ receptors

D. MacMillan,C. Kennedy,J. G. McCarron

Abstract

View articletitled, ATP inhibits Ins(1,4,5)P3-evoked Ca2+ release in smooth muscle via P2Y1 receptors

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‘In parallel’ interconnectivity of the dorsal longitudinal anastomotic vessels requires both VEGF signaling and circulatory flow

Tomasz Zygmunt,Sean Trzaska,Laura Edelstein,Johnathon Walls,Saathyaki Rajamani,Nicholas Gale,Laura Daroles,Craig Ramírez,Florian Ulrich,Jesús Torres-Vázquez

Abstract

View articletitled, ‘In parallel’ interconnectivity of the dorsal longitudinal anastomotic vessels requires both VEGF signaling and circulatory flow

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Oxygen sensing by the prolyl-4-hydroxylase PHD2 within the nuclear compartment and the influence of compartmentalisation on HIF-1 signalling

Friederike Katharina Pientka,Jun Hu,Susann Gaby Schindler,Britta Brix,Anika Thiel,Olaf Jöhren,Joachim Fandrey,Utta Berchner-Pfannschmidt,Reinhard Depping

Abstract

View articletitled, Oxygen sensing by the prolyl-4-hydroxylase PHD2 within the nuclear compartment and the influence of compartmentalisation on HIF-1 signalling

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Functional involvement of Rab1A in microtubule-dependent anterograde melanosome transport in melanocytes

Morié Ishida,Norihiko Ohbayashi,Yuto Maruta,Yuka Ebata,Mitsunori Fukuda

Abstract

View articletitled, Functional involvement of Rab1A in microtubule-dependent anterograde melanosome transport in melanocytes

Supplementary information

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Syndecan-1 controls cell migration by activating Rap1 to regulate focal adhesion disassembly

William A. Altemeier,Saundra Y. Schlesinger,Catherine A. Buell,William C. Parks,Peter Chen

Abstract

View articletitled, Syndecan-1 controls cell migration by activating Rap1 to regulate focal adhesion disassembly

Supplementary information

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AtTPR7 is a chaperone-docking protein of the Sec translocon in Arabidopsis

Regina Schweiger,Nina C. Müller,Manfred J. Schmitt,Jürgen Soll,Serena Schwenkert

Abstract

View articletitled, AtTPR7 is a chaperone-docking protein of the Sec translocon in Arabidopsis

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Class E compartments form in response to ESCRT dysfunction in yeast due to hyperactivity of the Vps21 Rab GTPase

Matthew R. G. Russell,Tess Shideler,Daniel P. Nickerson,Matt West,Greg Odorizzi

Abstract

View articletitled, Class E compartments form in response to ESCRT dysfunction in yeast due to hyperactivity of the Vps21 Rab GTPase

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PKA isoforms coordinate mRNA fate during nutrient starvation

Vanesa Tudisca,Clare Simpson,Lydia Castelli,Jennifer Lui,Nathaniel Hoyle,Silvia Moreno,Mark Ashe,Paula Portela

Abstract

View articletitled, PKA isoforms coordinate mRNA fate during nutrient starvation

Supplementary information

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PINCH-1 promotes Bcl-2-dependent survival signalling and inhibits JNK-mediated apoptosis in the primitive endoderm

Eloi Montanez,Esra Karaköse,Denise Tischner,Andreas Villunger,Reinhard Fässler

Abstract

View articletitled, PINCH-1 promotes Bcl-2-dependent survival signalling and inhibits JNK-mediated apoptosis in the primitive endoderm

Supplementary information

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Impact of a selfish B chromosome on chromatin dynamics and nuclear organization in Nasonia

Megan M. Swim,Kelsey E. Kaeding,Patrick M. Ferree

Abstract

View articletitled, Impact of a selfish B chromosome on chromatin dynamics and nuclear organization in Nasonia

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ARTICLE OF INTEREST IN OTHER COB JOURNALS

FROM DEVELOPMENT

Torso RTK controls Capicua degradation by changing its subcellular localization

Oliver Grimm,Victoria Sanchez Zini,Yoosik Kim,Jordi Casanova,Stanislav Y. Shvartsman,Eric Wieschaus

View articletitled, Torso RTK controls Capicua degradation by changing its subcellular localization

Draper acts through the JNK pathway to control synchronous engulfment of dying germline cells by follicular epithelial cells

Jon Iker Etchegaray,Allison K. Timmons,Adam P. Klein,Tracy L. Pritchett,Elaine Welch,Tracy L. Meehan,Christy Li,Kimberly McCall

View articletitled, Draper acts through the JNK pathway to control synchronous engulfment of dying germline cells by follicular epithelial cells

IN THIS ISSUE

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Accepted manuscripts

Cadherins and Growth Factor Receptors: ligand selective mechano-switches at cadherin junctions

Vinh Vu, Brendan Sullivan, Evan Hebner, Zainab Rahil, Yubo Zou, Deborah Leckband

Counterregulatory roles of GLI2 and GLI3 in osteogenic differentiation via Gli1 expression

Yuto Takahashi, Yamato Ishida, Saishu Yoshida, Hye-Won Shin, Yohei Katoh, Kazuhisa Nakayama

The conserved K3 residue in the N-terminal region of Rab10 small GTPase is required for tubular endosome formation: N-terminal tagging causes Rab10 dysfunction

Rinka Hata, Akira Sugawara, Mitsunori Fukuda

Mitochondrial phosphatase PPTC7 promotes EGFR recycling by facilitating VPS4A endosomal localization

Rahul Baroi, Hilal Ahmad Reshi, SubbaReddy Maddika

A protein interaction map of the myosin Myo2 reveals a role of Alo1 in mitochondrial inheritance in yeast

Xenia Chelius, Nathalie Rausch, Veronika Bartosch, Maria Klecker, Till Klecker, Benedikt Westermann

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CELL SCIENCE AT A GLANCE

COMMENTARY

SHORT REPORT

RESEARCH ARTICLE

ARTICLE OF INTEREST IN OTHER COB JOURNALS

FROM DEVELOPMENT

IN THIS ISSUE

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