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Volume 125, Issue 10

May 2012

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Cover image

Cover Image

Cover: Imaris (Bitplane) was used to create a composite 3D visualisation of autophagosomes (red) and lysosomes (green) in MDA-MB-231 cells that have been treated with rapamycin to induce autophagy. Nuclei were stained with DAPI. The green and red objects were rendered as solid surfaces on the basis of the fluorescence from green-labelled LAMP2 and red-labelled LC3. The image was composed by Margaret O'Prey, Ewan McGhee, Jim O'Prey and Kevin Ryan (The Beatson Institute for Cancer Research, UK). See Commentary by E. Y. Liu and K. M. Ryan pp. 2349−2358.
Table of contents

ISSN 0021-9533

EISSN 1477-9137

In this issue

STICKY WICKET
CELL SCIENCE AT A GLANCE
COMMENTARY
RESEARCH ARTICLE
ERRATUM
ARTICLE OF INTEREST IN OTHER COB JOURNALS
- FROM DEVELOPMENT
IN THIS ISSUE

STICKY WICKET

The interactome

X-Gal

Extract

View articletitled, The interactome

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CELL SCIENCE AT A GLANCE

Ubiquitin-like proteins and autophagy at a glance

Tomer Shpilka,Noboru Mizushima,Zvulun Elazar

Extract

View articletitled, Ubiquitin-like proteins and autophagy at a glance

Supplementary information

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COMMENTARY

Autophagy and cancer – issues we need to digest

Emma Y. Liu,Kevin M. Ryan

Abstract

View articletitled, Autophagy and cancer – issues we need to digest

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Autophagy and cell growth – the yin and yang of nutrient responses

Thomas P. Neufeld

Abstract

View articletitled, Autophagy and cell growth – the yin and yang of nutrient responses

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RESEARCH ARTICLE

RhoB regulates uPAR signalling

Daniela Alfano,Pia Ragno,M. Patrizia Stoppelli,Anne J. Ridley

Abstract

View articletitled, RhoB regulates uPAR signalling

Supplementary information

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FRET imaging and statistical signal processing reveal positive and negative feedback loops regulating the morphology of randomly migrating HT-1080 cells

Katsuyuki Kunida,Michiyuki Matsuda,Kazuhiro Aoki

Abstract

View articletitled, FRET imaging and statistical signal processing reveal positive and negative feedback loops regulating the morphology of randomly migrating HT-1080 cells

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GAS2L3, a target gene of the DREAM complex, is required for proper cytokinesis and genomic stability

Patrick Wolter,Kathrin Schmitt,Marc Fackler,Heidi Kremling,Leona Probst,Stefanie Hauser,Oliver J. Gruss,Stefan Gaubatz

Abstract

View articletitled, GAS2L3, a target gene of the DREAM complex, is required for proper cytokinesis and genomic stability

Supplementary information

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Chronic photo-oxidative stress and subsequent MCP-1 activation as causative factors for age-related macular degeneration

Mihoko Suzuki,Motokazu Tsujikawa,Hiroyuki Itabe,Zhao-Jiang Du,Ping Xie,Nagakazu Matsumura,Xiaoming Fu,Renliang Zhang,Koh-hei Sonoda,Kensuke Egashira,Stanley L. Hazen,Motohiro Kamei

Abstract

View articletitled, Chronic photo-oxidative stress and subsequent MCP-1 activation as causative factors for age-related macular degeneration

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Membrane lipid composition and its physicochemical properties define cell vulnerability to aberrant protein oligomers

Elisa Evangelisti,Cristina Cecchi,Roberta Cascella,Caterina Sgromo,Matteo Becatti,Christopher M. Dobson,Fabrizio Chiti,Massimo Stefani

Abstract

View articletitled, Membrane lipid composition and its physicochemical properties define cell vulnerability to aberrant protein oligomers

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Regulation of sphingolipid synthesis through Orm1 and Orm2 in yeast

Ming Liu,Chunjuan Huang,Surendranath R. Polu,Roger Schneiter,Amy Chang

Abstract

View articletitled, Regulation of sphingolipid synthesis through Orm1 and Orm2 in yeast

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Re-replication induced by geminin depletion occurs from G2 and is enhanced by checkpoint activation

Kathleen Klotz-Noack,Debbie McIntosh,Nicholas Schurch,Norman Pratt,J. Julian Blow

Abstract

View articletitled, Re-replication induced by geminin depletion occurs from G2 and is enhanced by checkpoint activation

Supplementary information

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Wnt3a-stimulated LRP6 phosphorylation is dependent upon arginine methylation of G3BP2

Rama Kamesh Bikkavilli,Craig C. Malbon

Abstract

View articletitled, Wnt3a-stimulated LRP6 phosphorylation is dependent upon arginine methylation of G3BP2

Supplementary information

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The Rac GEF ZizB regulates development, cell motility and cytokinesis in Dictyostelium

Nicholl K. Pakes,Douwe M. Veltman,Francisco Rivero,Jamal Nasir,Robert Insall,Robin S. B. Williams

Abstract

View articletitled, The Rac GEF ZizB regulates development, cell motility and cytokinesis in Dictyostelium

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Cancer-associated variant expression and interaction of CIZ1 with cyclin A1 in differentiating male germ cells

Erin A. Greaves,Nikki A. Copeland,Dawn Coverley,Justin F. X. Ainscough

Abstract

View articletitled, Cancer-associated variant expression and interaction of CIZ1 with cyclin A1 in differentiating male germ cells

Supplementary information

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N-glycosylation alters cadherin-mediated intercellular binding kinetics

Matthew D. Langer,Huabei Guo,Nitesh Shashikanth,J. Michael Pierce,Deborah E. Leckband

Abstract

View articletitled, N-glycosylation alters cadherin-mediated intercellular binding kinetics

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Heterodimerization of serotonin receptors 5-HT_1A and 5-HT₇ differentially regulates receptor signalling and trafficking

Ute Renner,Andre Zeug,Andrew Woehler,Marcus Niebert,Alexander Dityatev,Galina Dityateva,Nataliya Gorinski,Daria Guseva,Dalia Abdel-Galil,Matthias Fröhlich,Frank Döring,Erhard Wischmeyer,Diethelm W. Richter,Erwin Neher,Evgeni G. Ponimaskin

Abstract

View articletitled, Heterodimerization of serotonin receptors 5-HT1A and 5-HT7 differentially regulates receptor signalling and trafficking

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Sculpting the endomembrane system in deep time: high resolution phylogenetics of Rab GTPases

Marek Elias,Andrew Brighouse,Carme Gabernet-Castello,Mark C. Field,Joel B. Dacks

Abstract

View articletitled, Sculpting the endomembrane system in deep time: high resolution phylogenetics of Rab GTPases

Supplementary information

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RECQL4 is essential for the transport of p53 to mitochondria in normal human cells in the absence of exogenous stress

Siddharth De,Jyoti Kumari,Richa Mudgal,Priyanka Modi,Shruti Gupta,Kazunobu Futami,Hideyuki Goto,Noralane M. Lindor,Yasuhiro Furuichi,Debasisa Mohanty,Sagar Sengupta

Abstract

View articletitled, RECQL4 is essential for the transport of p53 to mitochondria in normal human cells in the absence of exogenous stress

Supplementary information

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Nuclear inheritance and genetic exchange without meiosis in the binucleate parasite Giardia intestinalis

Meredith L. Carpenter,Zoe June Assaf,Stéphane Gourguechon,W. Zacheus Cande

Abstract

View articletitled, Nuclear inheritance and genetic exchange without meiosis in the binucleate parasite Giardia intestinalis

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CDK regulates septin organization through cell-cycle-dependent phosphorylation of the Nim1-related kinase Gin4

Chang-Run Li,Jie-Ying Au Yong,Yan-Ming Wang,Yue Wang

Abstract

View articletitled, CDK regulates septin organization through cell-cycle-dependent phosphorylation of the Nim1-related kinase Gin4

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ERRATUM

Meiotic actin rings are essential for proper sporulation in fission yeast

Hongyan Yan,Mohan K. Balasubramanian

Extract

View articletitled, Meiotic actin rings are essential for proper sporulation in fission yeast

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The non-coding 3′ UTR of CD44 induces metastasis by regulating extracellular matrix functions

Zina Jeyapalan Rutnam,Burton B. Yang

Extract

View articletitled, The non-coding 3′ UTR of CD44 induces metastasis by regulating extracellular matrix functions

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ARTICLE OF INTEREST IN OTHER COB JOURNALS

FROM DEVELOPMENT

The novel intestinal filament organizer IFO-1 contributes to epithelial integrity in concert with ERM-1 and DLG-1

Katrin Carberry,Tobias Wiesenfahrt,Florian Geisler,Stephanie Stöcker,Harald Gerhardus,Daniel Überbach,Wayne Davis,Erik Jorgensen,Rudolf E. Leube,Olaf Bossinger

View articletitled, The novel intestinal filament organizer IFO-1 contributes to epithelial integrity in concert with ERM-1 and DLG-1

DE-Cadherin regulates unconventional Myosin ID and Myosin IC in Drosophila left-right asymmetry establishment

Astrid G. Petzoldt,Jean-Baptiste Coutelis,Charles Géminard,Pauline Spéder,Magali Suzanne,Delphine Cerezo,Stéphane Noselli

View articletitled, DE-Cadherin regulates unconventional Myosin ID and Myosin IC in Drosophila left-right asymmetry establishment

IN THIS ISSUE

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Accepted manuscripts

Formin 3 stabilizes the cytoskeleton of Drosophila tendon cells, thus enabling them to resist muscle tensile forces

Helena Pissarek, Na Huang, Leanna H. Frasch, Hermann Aberle, Manfred Frasch

A dual-purification system to isolate mitochondrial subpopulations

Corey N. Cunningham, Jonathan G. Van Vranken, Jakeline Larios, Katarina Heyden, Steven P. Gygi, Jared Rutter

An endoplasmic reticulum-associated structure sequesters misassembled FG-Nups to help maintain NPC function

Madison Pletan, Emily Wang, Luke Gohmann, Billy Tsai

Compound screening in human airway basal cells identifies Wnt pathway activators as potential pro-regenerative therapies

Yuki Ishii, Jessica C. Orr, Marie-Belle El Mdawar, Denise R.Bairros de Pilger, David R. Pearce, Kyren A. Lazarus, Rebecca E. Graham, Marko Z. Nikolić, Robin Ketteler, Neil O. Carragher, Sam M. Janes, Robert E. Hynds

ATG9A vesicles are a subtype of intracellular nanovesicle

Mary Fesenko, Daniel J. Moore, Peyton Ewbank, Elizabeth Courthold, Stephen J. Royle

More accepted manuscripts

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