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Volume 122, Issue 3

February 2009

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Cover: The hidden dynamics of the positive- and negative-feedback mechanisms and the functional role of RKIP in the ERK pathway are elucidated through a combined study of biochemical in vitro experiments and in silico simulations. See article by S.-Y. Shin et al. (pp. 425-435).
Table of contents

ISSN 0021-9533

EISSN 1477-9137

In this issue

CELL SCIENCE AT A GLANCE
OPINION
RESEARCH ARTICLE
IN THIS ISSUE
ARTICLE OF INTEREST IN OTHER COB JOURNALS
- FROM DEVELOPMENT

CELL SCIENCE AT A GLANCE

ATR signaling at a glance

Bunsyo Shiotani,Lee Zou

Extract

View articletitled, ATR signaling at a glance

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OPINION

A common cofilin activity cycle in invasive tumor cells and inflammatory cells

Jacco van Rheenen,John Condeelis,Michael Glogauer

Abstract

View articletitled, A common cofilin activity cycle in invasive tumor cells and inflammatory cells

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RESEARCH ARTICLE

Spontaneous phosphoinositide 3-kinase signaling dynamics drive spreading and random migration of fibroblasts

Michael C. Weiger,Chun-Chao Wang,Matej Krajcovic,Adam T. Melvin,John J. Rhoden,Jason M. Haugh

Abstract

View articletitled, Spontaneous phosphoinositide 3-kinase signaling dynamics drive spreading and random migration of fibroblasts

Supplementary information

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Vav proteins are necessary for correct differentiation of mouse cecal and colonic enterocytes

John Y. Liu,Hiroshi Seno,Ana V. Miletic,Jason C. Mills,Wojciech Swat,Thaddeus S. Stappenbeck

Abstract

View articletitled, Vav proteins are necessary for correct differentiation of mouse cecal and colonic enterocytes

Supplementary information

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Regulation of Rap1 activity is required for differential adhesion, cell-type patterning and morphogenesis in Dictyostelium

Katie Parkinson,Parvin Bolourani,David Traynor,Nicola L. Aldren,Robert R. Kay,Gerald Weeks,Christopher R. L. Thompson

Abstract

View articletitled, Regulation of Rap1 activity is required for differential adhesion, cell-type patterning and morphogenesis in Dictyostelium

Supplementary information

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Combinatorial probabilistic chromatin interactions produce transcriptional heterogeneity

Ty C. Voss,R. Louis Schiltz,Myong-Hee Sung,Thomas A. Johnson,Sam John,Gordon L. Hager

Abstract

View articletitled, Combinatorial probabilistic chromatin interactions produce transcriptional heterogeneity

Supplementary information

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FAK engages multiple pathways to maintain survival of fibroblasts and epithelia – differential roles for paxillin and p130Cas

Nadia K. Zouq,James A. Keeble,Jennefer Lindsay,Anthony J. Valentijn,Lu Zhang,Deborah Mills,Christopher E. Turner,Charles H. Streuli,Andrew P. Gilmore

Abstract

View articletitled, FAK engages multiple pathways to maintain survival of fibroblasts and epithelia – differential roles for paxillin and p130Cas

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Subcellular localization and dimerization of APLP1 are strikingly different from APP and APLP2

Daniela Kaden,Philipp Voigt,Lisa-Marie Munter,Karolina D. Bobowski,Michael Schaefer,Gerd Multhaup

Abstract

View articletitled, Subcellular localization and dimerization of APLP1 are strikingly different from APP and APLP2

Supplementary information

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Connexin mutation that causes dominant congenital cataracts inhibits gap junctions, but not hemichannels, in a dominant negative manner

Eric A. Banks,Masoud M. Toloue,Qian Shi,Zifei Jade Zhou,Jialu Liu,Bruce J. Nicholson,Jean X. Jiang

Abstract

View articletitled, Connexin mutation that causes dominant congenital cataracts inhibits gap junctions, but not hemichannels, in a dominant negative manner

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EHD3 regulates early-endosome-to-Golgi transport and preserves Golgi morphology

Naava Naslavsky,Jenna McKenzie,Nihal Altan-Bonnet,David Sheff,Steve Caplan

Abstract

View articletitled, EHD3 regulates early-endosome-to-Golgi transport and preserves Golgi morphology

Supplementary information

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Dynamic complexes of A-type lamins and emerin influence adipogenic capacity of the cell via nucleocytoplasmic distribution of β-catenin

Katarzyna Tilgner,Kamila Wojciechowicz,Colin Jahoda,Christopher Hutchison,Ewa Markiewicz

Abstract

View articletitled, Dynamic complexes of A-type lamins and emerin influence adipogenic capacity of the cell via nucleocytoplasmic distribution of β-catenin

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The SAM domain of the RhoGAP DLC1 binds EF1A1 to regulate cell migration

Dandan Zhong,Jingfeng Zhang,Shuai Yang,Unice J. K. Soh,Jan Paul Buschdorf,Yi Ting Zhou,Daiwen Yang,Boon Chuan Low

Abstract

View articletitled, The SAM domain of the RhoGAP DLC1 binds EF1A1 to regulate cell migration

Supplementary information

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Positive- and negative-feedback regulations coordinate the dynamic behavior of the Ras-Raf-MEK-ERK signal transduction pathway

Sung-Young Shin,Oliver Rath,Sang-Mok Choo,Frances Fee,Brian McFerran,Walter Kolch,Kwang-Hyun Cho

Abstract

View articletitled, Positive- and negative-feedback regulations coordinate the dynamic behavior of the Ras-Raf-MEK-ERK signal transduction pathway

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IN THIS ISSUE

ARTICLE OF INTEREST IN OTHER COB JOURNALS

FROM DEVELOPMENT

An in vitro ES cell imprinting model shows that imprinted expression of the Igf2r gene arises from an allele-specific expression bias

Paulina A. Latos,Stefan H. Stricker,Laura Steenpass,Florian M. Pauler,Ru Huang,Basak H. Senergin,Kakkad Regha,Martha V. Koerner,Katarzyna E. Warczok,Christine Unger,Denise P. Barlow

View articletitled, An in vitro ES cell imprinting model shows that imprinted expression of the Igf2r gene arises from an allele-specific expression bias

Fasciclin 2, the Drosophila orthologue of neural cell-adhesion molecule, inhibits EGF receptor signalling

Yanlan Mao,Matthew Freeman

View articletitled, Fasciclin 2, the Drosophila orthologue of neural cell-adhesion molecule, inhibits EGF receptor signalling

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Accepted manuscripts

Formin 3 stabilizes the cytoskeleton of Drosophila tendon cells, thus enabling them to resist muscle tensile forces

Helena Pissarek, Na Huang, Leanna H. Frasch, Hermann Aberle, Manfred Frasch

A dual-purification system to isolate mitochondrial subpopulations

Corey N. Cunningham, Jonathan G. Van Vranken, Jakeline Larios, Katarina Heyden, Steven P. Gygi, Jared Rutter

An endoplasmic reticulum-associated structure sequesters misassembled FG-Nups to help maintain NPC function

Madison Pletan, Emily Wang, Luke Gohmann, Billy Tsai

Compound screening in human airway basal cells identifies Wnt pathway activators as potential pro-regenerative therapies

Yuki Ishii, Jessica C. Orr, Marie-Belle El Mdawar, Denise R.Bairros de Pilger, David R. Pearce, Kyren A. Lazarus, Rebecca E. Graham, Marko Z. Nikolić, Robin Ketteler, Neil O. Carragher, Sam M. Janes, Robert E. Hynds

ATG9A vesicles are a subtype of intracellular nanovesicle

Mary Fesenko, Daniel J. Moore, Peyton Ewbank, Elizabeth Courthold, Stephen J. Royle

More accepted manuscripts

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Call for papers - Cilia and Flagella: from Basic Biology to Disease

We are welcoming submissions for our upcoming special issue: Cilia and Flagella: from Basic Biology to Disease. This issue will be coordinated by two Guest Editors: Pleasantine Mill (University of Edinburgh) and Lotte Pedersen (University of Copenhagen). Extended submission deadline: 31 March 2025.

History of our journals

As our publisher, The Company of Biologists, turns 100 years old, read about Journal of Cell Science’s journey and explore the history of each of our sister journals: Development, Journal of Experimental Biology, Disease Models & Mechanisms and Biology Open.

Introducing our new Associate Editors

In this Editorial, JCS Editor-in-Chief Michael Way welcomes five new Associate Editors to the JCS team. These Associate Editors will expand our support for the wider cell biology community and handle articles in immune cell biology, proteostasis, imaging and image analysis, plant cell biology, and stem cell biology and modelling.

Diversity of microtubule arrays in animal cells at a glance

In this Cell Science at a Glance article, Emma van Grinsven and Anna Akhmanova provide an overview of the diverse microtubule arrays present in differentiated animal cells and discuss how these arrays form and function.

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Early-career researchers - working in an area covered by JCS - who would like to attend a microscopy training course, please apply. Deadline dates for 2025 applications: 7 March 2025 (decision by week commencing 21 April 2025) and 6 June 2025 (decision by week commencing 28 July 2025).

Issues

Cover Image

CELL SCIENCE AT A GLANCE

OPINION

RESEARCH ARTICLE

IN THIS ISSUE

ARTICLE OF INTEREST IN OTHER COB JOURNALS

FROM DEVELOPMENT

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