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Volume 120, Issue 23

December 2007

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Cover image

Cover Image

Cover: This ultrastructural image shows 'dystrophic neurites', a characteristic feature of the pathology in the Alzheimer disease (AD) brain. These structures, which are grossly swollen portions of an axon or sometimes a dendrite, are filled predominantly with autophagic vacuoles such as autophagosomes and autophagolysosomes, reflecting a pathological impairment in the crucial process of autophagy in AD. Disruption of autophagy has important implications for amyloid accumulation and neuron survival in this disease. See Commentary by Nixon (p.4081-4091).
Table of contents

ISSN 0021-9533

EISSN 1477-9137

In this issue

COMMENTARY
SHORT REPORT
RESEARCH ARTICLE
ARTICLE OF INTEREST IN OTHER COB JOURNALS
- FROM DEVELOPMENT
IN THIS ISSUE

COMMENTARY

New insights into PTEN

Tanja Tamguney,David Stokoe

Abstract

View articletitled, New insights into PTEN

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Autophagy, amyloidogenesis and Alzheimer disease

Ralph A. Nixon

Abstract

View articletitled, Autophagy, amyloidogenesis and Alzheimer disease

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SHORT REPORT

In vivo movement of the type V myosin Myo52 requires dimerisation but is independent of the neck domain

Agnes Grallert,Rebeca Martín-García,Steve Bagley,Daniel P. Mulvihill

Abstract

View articletitled, In vivo movement of the type V myosin Myo52 requires dimerisation but is independent of the neck domain

Supplementary information

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RESEARCH ARTICLE

Biogenesis of yeast dicarboxylate carrier: the carrier signature facilitates translocation across the mitochondrial outer membrane

Vincenzo Zara,Alessandra Ferramosca,Loredana Capobianco,Katrin M. Baltz,Olga Randel,Joachim Rassow,Ferdinando Palmieri,Panagiotis Papatheodorou

Abstract

View articletitled, Biogenesis of yeast dicarboxylate carrier: the carrier signature facilitates translocation across the mitochondrial outer membrane

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The cataract-inducing S50P mutation in Cx50 dominantly alters the channel gating of wild-type lens connexins

Adam M. DeRosa,Chun-Hong Xia,Xiaohua Gong,Thomas W. White

Abstract

View articletitled, The cataract-inducing S50P mutation in Cx50 dominantly alters the channel gating of wild-type lens connexins

Supplementary information

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Rescue of oogenesis in Cx37-null mutant mice by oocyte-specific replacement with Cx43

Tony Y. Li,Deanne Colley,Kevin J. Barr,Siu-Pok Yee,Gerald M. Kidder

Abstract

View articletitled, Rescue of oogenesis in Cx37-null mutant mice by oocyte-specific replacement with Cx43

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Interferon-γ and tumor necrosis factor-α sensitize primarily resistant human endometrial stromal cells to Fas-mediated apoptosis

Herbert Fluhr,Stefanie Krenzer,Gerburg M. Stein,Björn Stork,Margarita Deperschmidt,Diethelm Wallwiener,Sebastian Wesselborg,Marek Zygmunt,Peter Licht

Abstract

View articletitled, Interferon-γ and tumor necrosis factor-α sensitize primarily resistant human endometrial stromal cells to Fas-mediated apoptosis

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The increase of cell-membranous phosphatidylcholines containing polyunsaturated fatty acid residues induces phosphorylation of p53 through activation of ATR

Xu Hannah Zhang,Chunying Zhao,Zhongmin Alex Ma

Abstract

View articletitled, The increase of cell-membranous phosphatidylcholines containing polyunsaturated fatty acid residues induces phosphorylation of p53 through activation of ATR

Supplementary information

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Phosphorylation of WAVE2 by MAP kinases regulates persistent cell migration and polarity

Christopher M. Danson,Shirin M. Pocha,Graham B. Bloomberg,Giles O. Cory

Abstract

View articletitled, Phosphorylation of WAVE2 by MAP kinases regulates persistent cell migration and polarity

Supplementary information

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Mitochondrial electron-transport-chain inhibitors of complexes I and II induce autophagic cell death mediated by reactive oxygen species

Yongqiang Chen,Eileen McMillan-Ward,Jiming Kong,Sara J. Israels,Spencer B. Gibson

Abstract

View articletitled, Mitochondrial electron-transport-chain inhibitors of complexes I and II induce autophagic cell death mediated by reactive oxygen species

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Dynamin 2 mediates fluid-phase micropinocytosis in epithelial cells

Hong Cao,Jing Chen,Muyiwa Awoniyi,John R. Henley,Mark A. McNiven

Abstract

View articletitled, Dynamin 2 mediates fluid-phase micropinocytosis in epithelial cells

Supplementary information

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Functional analysis of homeodomain-containing transcription factor Lbx1 in satellite cells of mouse skeletal muscle

Shuichi Watanabe,Shunzo Kondo,Michiko Hayasaka,Kazunori Hanaoka

Abstract

View articletitled, Functional analysis of homeodomain-containing transcription factor Lbx1 in satellite cells of mouse skeletal muscle

Supplementary information

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The complete removal of cohesin from chromosome arms depends on separase

Masato Nakajima,Kazuki Kumada,Katsuyoshi Hatakeyama,Tetsuo Noda,Jan-Michael Peters,Toru Hirota

Abstract

View articletitled, The complete removal of cohesin from chromosome arms depends on separase

Supplementary information

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Rip11 is a Rab11- and AS160-RabGAP-binding protein required for insulin-stimulated glucose uptake in adipocytes

Gavin I. Welsh,Sophie E. Leney,Bethan Lloyd-Lewis,Matthew Wherlock,Andrew J. Lindsay,Mary W. McCaffrey,Jeremy M. Tavaré

Abstract

View articletitled, Rip11 is a Rab11- and AS160-RabGAP-binding protein required for insulin-stimulated glucose uptake in adipocytes

Supplementary information

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The processing of double-strand breaks and binding of single-strand-binding proteins RPA and Rad51 modulate the formation of ATR-kinase foci in yeast

Karine Dubrana,Haico van Attikum,Florence Hediger,Susan M. Gasser

Abstract

View articletitled, The processing of double-strand breaks and binding of single-strand-binding proteins RPA and Rad51 modulate the formation of ATR-kinase foci in yeast

Supplementary information

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NBS1 mediates ATR-dependent RPA hyperphosphorylation following replication-fork stall and collapse

Karoline C. Manthey,Stephen Opiyo,Jason G. Glanzer,Diana Dimitrova,James Elliott,Gregory G. Oakley

Abstract

View articletitled, NBS1 mediates ATR-dependent RPA hyperphosphorylation following replication-fork stall and collapse

Supplementary information

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MAP-kinase activity necessary for TGFβ1-stimulated mesangial cell type I collagen expression requires adhesion-dependent phosphorylation of FAK tyrosine 397

Tomoko Hayashida,Ming-Hua Wu,Amy Pierce,Anne-Christine Poncelet,John Varga,H. William Schnaper

Abstract

View articletitled, MAP-kinase activity necessary for TGFβ1-stimulated mesangial cell type I collagen expression requires adhesion-dependent phosphorylation of FAK tyrosine 397

Supplementary information

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ARTICLE OF INTEREST IN OTHER COB JOURNALS

FROM DEVELOPMENT

Stochastic patterning in the mouse pre-implantation embryo

Jens-Erik Dietrich,Takashi Hiiragi

View articletitled, Stochastic patterning in the mouse pre-implantation embryo

Argonaute 1 regulates the fate of germline stem cells in Drosophila

Lele Yang,Dongsheng Chen,Ranhui Duan,Laixin Xia,Jun Wang,Abrar Qurashi,Peng Jin,Dahua Chen

View articletitled, Argonaute 1 regulates the fate of germline stem cells in <em>Drosophila</em>

IN THIS ISSUE

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Accepted manuscripts alert

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Latest published articles alert

Accepted manuscripts

Counterregulatory roles of GLI2 and GLI3 in osteogenic differentiation via Gli1 expression

Yuto Takahashi, Yamato Ishida, Saishu Yoshida, Hye-Won Shin, Yohei Katoh, Kazuhisa Nakayama

The conserved K3 residue in the N-terminal region of Rab10 small GTPase is required for tubular endosome formation: N-terminal tagging causes Rab10 dysfunction

Rinka Hata, Akira Sugawara, Mitsunori Fukuda

Mitochondrial phosphatase PPTC7 promotes EGFR recycling by facilitating VPS4A endosomal localization

Rahul Baroi, Hilal Ahmad Reshi, SubbaReddy Maddika

A protein interaction map of the myosin Myo2 reveals a role of Alo1 in mitochondrial inheritance in yeast

Xenia Chelius, Nathalie Rausch, Veronika Bartosch, Maria Klecker, Till Klecker, Benedikt Westermann

Point contact-restricted cAMP signaling controls ephrin-A5-induced axon repulsion

Johann Bécret, Claudia Gomez-Bravo, Camille Michaud, Ahlem Assali, Naïg A. L. Chenais, Izeta Kankadze, Fiona Roche, Sandrine Couvet, Coralie Fassier, Xavier Nicol

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Call for papers - Cilia and Flagella: from Basic Biology to Disease

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We are excited to invite you to a unique scientific conference, celebrating the 100-year anniversary of The Company of Biologists, and bringing together our different communities. The conference will incorporate the Spring Meetings of the BSCB and the BSDB, the JEB Symposium Sensory Perception in a Changing World and a DMM programme on antimicrobial resistance. Find out more and register your interest to join us in March 2025 in Liverpool, UK.

Imaging interorganelle contacts at a glance

In this Cell Science at Glance article, Maria Clara Zanellati and colleagues describe an explosion of new methods : diffraction-limited, proximity-based, super-resolution and electron microscopy methods for visualizing interorganelle contacts.

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