Issues

Summary: We propose that phospholipid transfer at mitochondria-associated membranes (MAMs) co-transports cholesterol into and out of mitochondria. This process is stabilized by high binding energy, challenging protein-centric models of mitochondria cholesterol trafficking in non-sterodoigenic tissues.

Summary: We provide an overview of contacts between mitochondria and other membranous organelles, describing the interorganelle tethers involved and the factors that regulate the composition and functions of such contacts.

Summary: Mitochondrial proteins are mistargeted to various cellular compartments upon mitochondrial dysfunction. We review the fate of these mistargeted proteins and how quality control mechanisms mitigate their accumulation to maintain proteostasis.

Summary: In light of research advances recognizing the roles mitochondria play in directing cellular processes and behaviors, we propose reframing mitochondria as the chief executive organelle of the cell.

Summary: A discussion of how the regulation of the synthesis of mitochondrial proteins is key to the adaptation of cellular function to changing metabolic needs and to trigger stress responses.

Summary: An examination of the morphological similarities between prokaryotic intracytoplasmic membranes and mitochondrial inner membranes, and whether cristae evolution has driven specialization of the mitochondrial lipidome.

Summary: Mitochondrial fission occurs in multiple contexts, mediating a variety of possible responses. This Review discusses how individual aspects of mitochondrial fission might be integrated to give a more holistic understanding.

Summary: Tumors can be caused by loss of succinate dehydrogenase (SDH), resulting in oncogenic succinate accumulation. This imbalance can be reversed by restoring the missing SDH subunit, but not by riboflavin supplementation to boost SDH catalytic activity.

Summary: Mitochondrial membrane potential is spatially regulated in collectively migrating tissue by integrin adhesion and signaling in leader row cells.

Summary: The Caenorhabditis elegans nuclear hormone receptor NHR-85, a putative orthologue of human PPARδ, is an essential regulator of mitochondrial energy metabolism and protects against α-synuclein aggregation.

Summary: Lipidomics and proteomics of mitochondrial fractions and whole cells lacking the membrane protein OCIAD1 suggest a role as a dually localized protein balancing mitochondrial and peroxisomal lipid metabolism.

Summary: Imaging the cytosol in three dimensions greatly aids in understanding cellular processes. We used cryo-scanning transmission electron tomography to study mitochondrial fission in the absence of mitochondrial fusion factor.

Summary: Supplementation of pyruvate plus uridine prevents PE-induced cardiac hypertrophy in H9c2 cells and zebrafish embryos.

Summary: The dynamics of Clu ribonucleoprotein particles are governed by its functional protein level and translating ribosomes, giving insight into how these unique particles regulate mitochondrial biology in Drosophila.

Summary: We define a TOM complex interactome, revealing diverse interaction partners that include the new interactors MAPL, ATAD1 and TRABD. We show that TRABD is likely involved in carrier protein translocation.

Summary: This study sheds new light on the submitochondrial location and the biogenesis of the highly conserved protein Mix17 as a first step to elucidate the function of Mix17 and its orthologs.

Summary: This study demonstrates that ERMES deletion in Cryptococcus neoformans disrupts mitochondrial function, enhances drug sensitivity and diminishes virulence in C. elegans, emphasizing ERMES as a potential antifungal target.

Summary: Deletion of Miro1, which supports microtubule-based mitochondrial trafficking, in MEFs leads to hyper-phosphorylated ERK1/2, reduces cell proliferation and cell cycle progression, and alters global gene expression.

Summary: Mitochondrial dysfunction and lysosomal degradation of mitochondria (mitophagy) is induced after ischemia and reperfusion simulation in human engineered heart tissue, as shown with an endogenous pH-sensitive mitophagy reporter.

Summary: Myo19 and Miro1/2 regulate mitochondrial cristae organization via ER–mitochondrial membrane contact mediated lipid transfer, but not via the interaction with the intermembrane bridging complex component Mtx3.

Summary: Mitochondria–plasma membrane contact sites regulate the distribution and dynamics of mitochondria–ER membrane contact sites by controlling the positioning of the mitochondrial network.

Summary: Fis1, a mitochondrial fission protein, modulates bioenergetics and selective removal of mtDNA damage in response to radiation. Interestingly, Fis1 depletion alone blunts electron transport chain activity.

Summary: Following mitochondrial stress, the mitochondria unfolded protein response induces the transient assembly of stress granules which results in protection of cells from further damage.

Summary: A dual-purification scheme is used to isolate subpopulations of mitochondria based on their juxtaposition to various membrane-bound organelles. Some of these subpopulations have mitochondrial proteomes that are significantly different from an average proteome.