It is shown, by the Aoyama, Mann-Kopsch, and sudan black techniques that there is a definite series of changes in the pancreas acinar cell of the mouse after the subcutaneous injection of a prede-termined optimum dose of neutral red. These changes are similar to those observed in the fresh tissue. In the fixed preparations they are characterized by the appearance of argentophil, osmiophil, and sudanophil bodies having the position, number, general configuration, and relative size of the neutral red granules and aggregates. It is further observed that there is a shift of this substance from an apical position in the cell to a more basal one, apparently in response to the presence of neutral red.

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