Spinal ganglia of rabbits and cats were prepared for histological examination in a variety of ways. Dark staining multangular cells are present in sections after fixation with formaldehyde succeeded by (a) alcoholic dehydration; (b) sectioning with the freezing microtome. Sections treated in other ways, including freezing-drying, only have the typical small and large round cells. It is suggested that certain groups of cells, sensitized by formaldehyde fixation, can react by shrinkage on subsequent treatment by alcoholic dehydration or other procedures.

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