In the chicken, maternal IgG is deposited in the oocyte yolk and subsequently transported intact by the foetal chick yolk sac into the chick circulation. Such transport appears to require a specific membrane-localized IgG receptor. Using the assay of 125I-yolk IgG binding, we have investigated the existence and properties of such receptors in yolk sac tissue disks. We find that: (1) There are specific, 125I-IgG binding sites on yolk sac tissue; (2) specific yolk 125I-IgG binding has a distinct pH optimum at pH 6.0–6.3; (3) the apparent equilibrium dissociation constant of specific 125I-IgG binding is 2–3 X 10(−6) M; and (4) heterologous proteins compete less efficently than yolk IgG for 125I-IgG binding.
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JOURNAL ARTICLE| 01 October 1978
IgG receptors on foetal chick yolk sac
Online Issn: 1477-9137
Print Issn: 0021-9533
© 1978 by Company of Biologists
J Cell Sci (1978) 33 (1): 317–328.
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C.D. Linden, T.F. Roth; IgG receptors on foetal chick yolk sac. J Cell Sci 1 October 1978; 33 (1): 317–328. doi: https://doi.org/10.1242/jcs.33.1.317
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