Folic acid is known to be a chemoattractant of pre-aggregation cells of Dictyostelium discoideum. When supplied in pulses, folic acid induces biochemical oscillations and stimulates the development of pre-aggregation to aggregation-competent amoebae. The continuous supply of folic acid has no stimulatory effect. Folic-acid-induced oscillations are accompanied by periodic changes in the cyclic AMP concentration. Pulses of folic acid applied with rhythms between 7 and 11 min efficiently induce oscillations. In contrast, a rhythm of 2 min neither induces oscillations nor suppresses them. Cells start to oscillate with a rhythm of about 8 min. This inherent rhythm is independent of the inducing rhythm. Oscillating cells are less sensitive to folic acid than pre-oscillating ones. They respond only to high concentrations of folic acid which also interact with the oscillating system.
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JOURNAL ARTICLE| 01 October 1977
Oscillations and cell development in Dictyostelium discoideum stimulated by folic acid pulses
Online Issn: 1477-9137
Print Issn: 0021-9533
© 1977 by Company of Biologists
J Cell Sci (1977) 27 (1): 105–114.
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B. Wurster, K. Schubiger; Oscillations and cell development in Dictyostelium discoideum stimulated by folic acid pulses. J Cell Sci 1 October 1977; 27 (1): 105–114. doi: https://doi.org/10.1242/jcs.27.1.105
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