We have studied the growth in vitro of a lymphoma × fibroblast hybrid and several melanoma × fibroblast hybrids in which malignancy is suppressed. The parental cells, the hybrids, and malignant segregants derived from the hybrids were analysed for serum requirement, cloning efficiency in soft agarose, density-dependent inhibition of growth, and secretion of plasminogen-activating enzyme. One malignant segregant from the lymphoma × fibroblast cross was found by a number of criteria to have a more highly ‘transformed’ phenotype than the hybrid from which it was derived. However, in the case of the melanoma × fibroblast crosses, none of the parameters examined could be correlated in a direct way with malignancy.
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JOURNAL ARTICLE| 01 June 1977
Growth in vitro of tumour cell × fibroblast hybrids in which malignancy is suppressed
Online Issn: 1477-9137
Print Issn: 0021-9533
© 1977 by Company of Biologists
J Cell Sci (1977) 25 (1): 73–86.
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D.S. Straus, J. Jonasson, H. Harris; Growth in vitro of tumour cell × fibroblast hybrids in which malignancy is suppressed. J Cell Sci 1 June 1977; 25 (1): 73–86. doi: https://doi.org/10.1242/jcs.25.1.73
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