This article includes recent preLights posts that discuss preprints in the field of cell biology.
Featured preLight
Target cell tension regulates macrophage trogocytosis by Caitlin E. Cornell et al.
Visual summary of the preprint from Cornell et al. (bioRxiv) created by Felipe Del Valle Batalla.
preLighter(s)
Felipe Del Valle Batalla, Postdoc, National Institutes of Health, Bethesda, USA
Why it was selected
This research provides compelling evidence that physical properties, particularly target stiffness, influence macrophage behaviour. Personally, it also feels interesting since mechanosensing-related cell behaviour is a promising area that could be explored further to help shape the immune response and develop new therapies. Finally, this work suggests that trogocytosis might be much more common than previously thought, especially when macrophages encounter softer targets like cells.
Other relevant preLight posts
Fis1 is required for the development of the dendritic mitochondrial network in pyramidal cortical neurons by Klaudia Strucinska et al.
Fis1 unexpectedly regulates dendritic mitochondrial dynamics by promoting fission/fusion balance and motility, impacting neuronal function and connectivity.
Selected by Felipe Del Valle Batalla. Read the preLight.
Mechanical stresses govern myoblast fusion and myotube growth by Yoann Le Toquin et al.
Muscles in motion: How stressful dance floors turn cells into synchronised superstars.
Selected by Vibha Singh and Prasanna Padmanaban. Read the preLight.
IMMClock reveals immune aging and T cell function at single-cell resolution by Yael Gurevich Schmidt et al.
Time flies when you're… a cell!
Selected by Jessica Chevallier. Read the preLight.
Adenine DNA methylation associated to transcription is widespread across eukaryotes by Pedro Romero Charria et al.
Breaking paradigms: Finding 6mA DNA methylation in eukaryotes.
Selected by Francisco Falcon. Read the preLight.
Levetiracetam prevents AΒ42 production through SV2a-dependent modulation of App processing in Alzheimer's disease models by Nalini R. Rao et al.
A promising therapeutic role for a synaptic vesicle binding drug in Alzheimer's disease.
Selected by Jawdat Sandakly. Read the preLight.
Polystyrene nanoplastics promote neurodegeneration by catalyzing TDP43 hyperphosphorylation by Winanto et al.
The smoking gun: Plastic is harmful for your neurons.
Selected by Manuel Lessi. Read the preLight.
Coagulative Granular Hydrogels with an Enzyme Catalyzed Fibrin Network for Endogenous Tissue Regeneration by Zhipeng Deng et al.
Fibrin gels to glue granular units.
Selected by Castro Johnbosco. Read the preLight.
New evidence for the presence and function of phosphoinositides (PPIs) in the chloroplast by Mastoureh Sedaghatmehr et al.
PPIs: The messengers between organelles in plant cells.
Selected by Shreya Pramanik. Read the preLight.
Leukocytes use endothelial membrane tunnels to extravasate the vasculature by Werner J. van der Meer et al.
No road? No problem! Squeezing through cell tunnels helps leukocytes reach their target sites.
Selected by Felipe Del Valle Batalla. Read the preLight.
Motor Clustering Enhances Kinesin-driven Vesicle Transport by Rui Jiang et al.
Teamwork makes the dream work - motor organisation influences the efficiency of cargo transport in cells.
Selected by Sharvari Pitke. Read the preLight.
Deep learning-based predictions of gene perturbation effects do not yet outperform simple linear methods by Constantin Ahlmann-Eltze et al.
Zen of neural networks: Simple is (still) better than complex.
Selected by Benjamin Dominik Maier. Read the preLight.
Neural Basis of Number Sense in Larval Zebrafish by Peter Luu et al.
Zebrafish can sense numbers! This preprint reveals early emergence of number-selective neurons in larval zebrafish.
Selected by Muhammed Sinan Malik. Read the preLight.
Actin-based deformations of the nucleus control multiciliated ependymal cell differentiation by Marianne Basso et al.
Actin up under pressure: cell differentiation and nuclear deformation.
Selected by Ryan Harrison. Read the preLight.
Long range mutual activation establishes Rho and Rac polarity during cell migration by Henry De Belly et al.
Rac and Rho team up! Long-distance mechanochemical coordination for migration.
Selected by Vibha Singh. Read the preLight.
Intracellular diffusion in the cytoplasm increases with cell size in fission yeast by Catherine Tan et al.
Size matters: Larger yeast cells boost cytoplasmic diffusion.
Selected by Leeba Ann Chacko and Sameer Thukral. Read the preLight.
Deciphering the nanoscale architecture of presynaptic actin using a micropatterned presynapse-on-glass model by Sofia Tumminia et al.
An arranged bumpy road to study the presynapse: A novel setup to explore neuronal architecture.
Selected by Felipe Del Valle Batalla. Read the preLight.
Golgi compaction facilitates microtubule nucleation to drive adult vertebrate peripheral neuron regeneration by Alice E Mortimer et al.
Rebuilding nerves: Golgi compaction paves the way to neuron repair!
Selected by Vibha Singh. Read the preLight.
Non-disruptive inducible labeling of ER-membrane contact sites using the Lamin B Receptor by Laura Downie et al.
Time to “LaBeRl” your contacts: The Royle lab develop a method for labelling ER membrane contact sites without changing the number, extent, or distance of the contacts.
Selected by Jonathan Townson. Read the preLight.
Global coordination of protrusive forces in migrating immune cells by Patricia Reis-Rodrigues et al.
A mechanosensitive actin cushion empowers dendritic cells to dilate a path while maintaining a coordinated cell body motion.
Selected by Yohalie Kalukula. Read the preLight.
