First person – Yuka Takeo

Yuka Takeo

How would you explain the main findings of your paper in lay terms?

To maintain normal cell function, essential molecules must be transported to specific destinations within the cell to function properly – much like a delivery service ensures the transportation and proper delivery of packages. A protein complex called ‘retromer’ is a crucial piece of cellular machinery that facilitates this transport process by sorting cellular ‘cargo’. In our study, we find that the activity of another protein, γ-secretase, plays an important role in enabling retromer to transport cargo to its correct destination. Interestingly, dysfunction in both retromer and γ-secretase has previously been linked to the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson’s disease.

Were there any specific challenges associated with this project? If so, how did you overcome them?

No specific challenges with regards to the physical experimentation required for this project come to mind. However, the main challenge lay in the subject matter being outside my primary research focus in virology. The inspiration for this project came from one figure in another paper from my lab, which we found particularly interesting and worth exploring further. Thanks to the guidance of Dr Chris Burd and support from other collaborators, the transition to publishing our first non-virology paper was much smoother.

Why did you choose Journal of Cell Science for your paper?

We chose to submit to Journal of Cell Science based on the recommendation of a PI in the field, who praises the journal's reliable, high-quality nature of publications. He also assured us that we would receive valuable yet fair feedback on our manuscript – and he was absolutely right!

Have you had any significant mentors who have helped you beyond supervision in the lab? How was their guidance special?

I have always been fortunate to have great colleagues in the lab who became informal mentors to me. We openly discussed ideas without hesitation, and they often shared practical tips for troubleshooting and planning experiments efficiently. Our casual chats and shared experiences not only helped me stay mindful but also reduced my stress levels, creating a supportive lab environment.

What motivated you to pursue a career in science, and what have been the most interesting moments on the path that led you to where you are now?

Since I was a child in Japan, I dreamed of becoming a veterinarian – a goal I achieved in 2012. Initially, I planned to work as a veterinary clinician, but during my undergraduate studies, I fell in love with virology research. This shift allowed me to contribute to the well-being of both animals and humans through science. I am especially grateful to Dr Yoshikazu Tanaka, who taught me essential research skills and encouraged me to pursue graduate studies. Throughout my scientific career, the most rewarding moments have been when my research proved helpful in clinical settings or supported the work of others.

Who are your role models in science? Why?

My current PI, Dr Daniel DiMaio, is my role model in science. His deep and unwavering passion for science inspires me, and I greatly respect him both as a scientist and as a person. Throughout my career, I have worked in challenging environments, but the atmosphere in my current lab is highly supportive and welcoming. I am truly happy to work here.

What's next for you?

I thoroughly enjoy my current lab and would like to continue working with Dr DiMaio for the foreseeable future. Beyond my time here, I am open to exploring other opportunities but remain committed to continuing my research in the field of virology.

Tell us something interesting about yourself that wouldn't be on your CV

Outside of research, I enjoy practicing calligraphy, horseback riding and attending Zumba classes. I am also a loving mother to my five-year-old son.