This article includes recent preLights posts that discuss preprints in the field of cell biology.
Featured preLight
Clusters of lineage-specific genes are anchored by ZNF274 in repressive perinucleolar compartments by Martina Begnis et al.
Model. (Top) Nucleolar tethering of ZNF274-bound clusters is functional to establish silencing of extended genomic regions and segregate them in repressive domains (in dark pink) that modulate access of CTCF and cohesin complexes to enable selective gene expression. (Bottom) Ablation of ZNF274 triggers loss of repressive chromatin marks, de novo CTCF binding and altered 3D spatial organization of the same genomic neighborhoods (in light pink), thus precluding the cell-specific fine-tuning of isoform diversity. The figure panel was created with BioRender.com
preLighter(s)
Silvia Carvalho, PhD student at the Max Delbrück Center, Berlin, Germany
Why it was selected
By focusing on the role of ZNF274 in the nucleolus, this study expands our understanding of how gene expression mechanisms work across the different layers of gene regulation. I believe that holistic perspectives on gene regulation are essential to better understand gene expression dynamics.
Other relevant preLight posts
Light-microscopy based dense connectomic reconstruction of mammalian brain tissue by Mojtaba R. Tavakoli et al.
LICONN uses molecular labelling and deep learning to reconstruct brain circuitry, bridging the gap between EM and molecular specificity.
Selected by Cemre Coskun. Read the preLight.
Enhancer cooperativity can compensate for loss of activity over large genomic distances by Henry Thomas et al.
In order to understand complex gene regulatory landscapes, build them from scratch!
Selected by Milan Antonovic. Read the preLight.
Streptococcus pneumoniae augments circadian clock gene expression in zebrafish cells by Camila Morales Fénero et al.
This study provides compelling insights into the interactions between microbes and circadian rhythm that is understudied and overlooked.
Selected by UofA IMB565 and Fadi Sayegh and Mohammed Jalloh. Read the preLight.
Lipid-Based Transfection of Zebrafish Embryos: A Robust Protocol for Nucleic Acid Delivery by Aslihan Terzi et al.
Gene delivery in zebrafish made easy (finally!)
Selected by Roberto Rodríguez-Morales. Read the Read the preLight.
Alteration of long and short-term hematopoietic stem cell ratio causes myeloid-biased hematopoiesis by Katsuyuki Nishi et al.
Long lifespan shortens short-term hematopoietic stem cell proportion. Nishi et al. show how the ratio between long-term and short-term hematopoietic stem cells changes with age and plays a role in myeloid-biased hematopoiesis.
Selected by Manuel Vicente and Anaisa Ferreira. Read the preLight.
OGT prevents DNA demethylation and suppresses the expression of transposable elements in heterochromatin by restraining TET activity genome-wide by Hugo Sepulveda et al.
What keeps the TETs in check?
Selected by Mansi. Read the preLight.
Selected by Silvia Carvalho. Read the preLight.
Synergistic olfactory processing for social plasticity in desert locusts by Inga Petelski et al.
The smell of a movable feast: researchers investigate the neuronal basis of olfactory-mediated foraging behavior in locusts.
Selected by T. W. Schwanitz and Lukas Weiss. Read the preLight.
Holimap: an accurate and efficient method for solving stochastic gene network dynamics by Chen Jia, Ramon Grima
Breaking the curse of dimensionality: Chen Jia and Ramon Grima propose an efficient framework that accurately predicts stochastic time-dependent protein dynamics.
Selected by Benjamin Dominik Maier. Read the preLight.
Complementary Cytoskeletal Feedback Loops Control Signal Transduction Excitability and Cell Polarity by Jonathan Kuhn et al.
The cytoskeleton talks back and has a bi-directional influence on cell polarity.
Selected by Vibha Singh. Read the preLight.
Digital Microbe: A Genome-Informed Data Integration Framework for Collaborative Research on Emerging Model Organisms by Iva Veseli et al.
Allowing team science by sharing and curating model organism data more efficiently. “Digital Microbes” pave the way for interoperability, reproducibility, and collaborative microbial science.
Selected by Benjamin Dominik Maier and Jennifer Ann Black. Read the preLight.
Experience-dependent plasticity of a highly specific olfactory circuit in Drosophila melanogaster by Benjamin Fabian et al.
How flies get used to the smell of death: new study shows brain changes and behavioral adaptation in Drosophila to a highly repulsive odor.
Selected by T. W. Schwanitz. Read the preLight.
Invasion of glioma cells through confined space requires membrane tension regulation and mechano-electrical coupling via Plexin-B2 by Chrystian Junqueira Alves et al.
An axon guidance protein moonlights as a mechanosensitive regulator of tumour invasion: Alves and colleagues demonstrate Plexin-B2's key role in confined cell migration.
Selected by Jade Chan. Read the preLight.
Modeling transcriptional profiles of gene perturbation with a deep neural network by Wenke Liu et al.
Can ChatGPT predict DNA mutations from RNA expression values? This exciting manuscript finds that training a deep learning model with 978 transcript levels is sufficient to predict which gene got silenced following shRNA knockdown!
Selected by Raquel Moya. Read the preLight.
Excitable Rho dynamics drive cell contractions by sequentially inducing ERM protein-mediated actin-membrane attachment and actomyosin contractility by Seph Marshall-Burghardt et al.
“Unraveling cellular dance”: Rho directs edge retractions, ERMs lead the rhythm.
Selected by Vibha Singh. Read the preLight.
