A data-driven Boolean model explains memory subsets and evolution in CD8+ T cell exhaustion by Geena V. Ildefonso, Stacey D. Finley
Building upon a published mathematical model of T-cell exhaustion (Bolouri et al., 2020) to study the dynamics that give rise to CD8+ T-cell exhaustion.
Selected by Benjamin Dominik Maier. Read the preLight here.
Massively parallel protein-protein interaction measurement by sequencing (MP3-seq) enables rapid screening of protein heterodimers by Alexander Baryshev et al.
High-throughput sequencing of protein-protein interactions quantifies more than 100,000 interactions simultaneously with interaction strengths spanning several orders of magnitude.
Selected by Benjamin Dominik Maier. Read the preLight here.
Flat clathrin lattices are linked to metastatic potential in colorectal cancer by Charlotte Cresens et al.
It’s dangerous to be sticky – adhesive plasma membrane structures are associated with metastatic potential in colorectal cancer.
Selected by Emily Chan. Read the preLight here.
Mitotic heritability of DNA methylation at intermediately methylated sites is imprecise by Amir D. Hay et al.
Probabilistic Inheritance of Intermediate DNA Methylation Sites Across Somatic Cell Division.
Selected by Samantha Seah and Navin B Ramakrishna and Hui Ting Zhang. Read the preLight here.
CTCF is essential for proper mitotic spindle structure and anaphase segregation by Katherine Chiu et al.
CTCF is a critical factor in the maintenance of genomic stability in higher organisms. Find out more about how the authors in this work showed CTCF’s novel role in mitosis.
Selected by Saanjbati Adhikari. Read the preLight here.
Actin nucleators safeguard replication forks by limiting nascent strand degradation by Jadwiga Nieminuszczy et al.
Actin’ in the nucleus: better safe than broken.
Selected by Roberto Amadio. Read the preLight here.
marmite defines a novel conserved neuropeptide family mediating nutritional homeostasis by AP Francisco et al.
Love it or hate it: The discovery of the neuropeptide marmite reveals a family of neuropeptides involved in the regulation of protein intake.
Selected by Pablo Ranea Robles and Cláudia Gil. Read the preLight here.
BRCA1/BARD1 ubiquitinates PCNA in unperturbed conditions to promote replication fork stability and continuous DNA synthesis by Daniel Salas-Lloret et al.
The ‘‘harvesting of ubiquitin’’ reveals that the E3 ubiquitin ligase BRCA1/BARD1 prevents genome instability during replication.
Selected by Pierre Caron. Read the preLight here.
Quantification of gallium cryo-FIB milling damage in biological lamella by Bronwyn A. Lucas, Nikolaus Grigorieff
In this preprint, the authors quantify the damage caused by cryo-FIB milling to biological specimens and how this information can be leveraged to prepare samples for in situ structure determination.
Selected by Kanika Khanna. Read the preLight here.
Coordinated growth of linked epithelia is mediated by the Hippo pathway by Sophia Friesen, Iswar K. Hariharan
Roses are red, violets are blue, when the disk proper grows, hippo stretches peripodial epithelium too.
Selected by Girish Kale. Read the preLight here.
Conserved Chamber-Specific Polyploidy Maintains Heart Function in Drosophila by Archan Chakraborty et al.
The importance of being in the right place, with the right ploidy, at the right time- and how not to mend broken hearts.
Selected by Anastasia Moraiti. Read the preLight here.
Unclearing Microscopy by Ons M’Saad et al.
Unclearing microscopy: seeing human cells directly by eye.
Selected by Robert Mahen. Read the preLight here.
Single-strand mismatch and damage patterns revealed by single-molecule DNA sequencing by Mei Hong Liu et al.
Finding the fuse that ignited the bomb: Ultra-accurate sequencing of single-stranded precursors of DNA damage.
Selected by Kerryn Elliott. Read the preLight here.
Insm1 regulates the development of mTECs and immune tolerance by Wehuai Tao et al.
A new player in establishing immune tolerance: How Insm1 regulates mTEC gene expression.
Selected by Marina Schernthanner and Jessica Chevallier. Read the preLight here.
Nutrient-regulated dynamics of chondroprogenitors in the postnatal murine growth plate by Takeshi Oichi et al.
Fasted bones grow fast later: chondroprogenitors in the growth plate of murine long bones adapt to dietary restriction, leading to catch-up growth during refeeding.
Selected by Alberto Rosello-Diez and Boya (Hannah) Zhang and Chee Ho H’ng. Read the preLight here.
Small leucine-rich proteoglycans inhibit CNS regeneration by modifying the structural and mechanical properties of the lesion environment by Julia Kolb et al.
Who is the culprit? Small leucine-rich proteoglycans inhibit axonal regrowth in the lesioned zebrafish spinal cord by changing the structure and mechanics of the extracellular matrix.
Selected by Laura Celotto. Read the preLight here.
Phosphoproteomics of cellular mechanosensing reveals NFATC4 as a regulator of myofibroblast activity by Laura F. Mattner et al.
Phosphoproteomic analysis of human lung fibroblasts identifies a stiffness threshold above which fibroblasts undergo fibrosis-associated changes and finds NFATC4 as a potential therapeutic target.
The phosphodiesterase 2A regulates lymphatic endothelial development via cGMP-mediated control of Notch signaling by Claudia Carlantoni et al.
An essential function for the phosphodiesterase 2A during regulation of lymphatic vessel maturation.
Selected by Andreas van Impel and Sanjay Sunil Kumar. Read the preLight here.
3D genome organization around nuclear speckles drives mRNA splicing efficiency by Prashant Bhat et al.
mRNA in the right place, at the right time: a new preprint explores how dynamic organization of genomic DNA around nuclear speckles determines mRNA splicing efficiency.
Selected by Diego Martínez. Read the preLight here.
Bovine blastocyst like structures derived from stem cell cultures by Carlos A. Pinzón-Arteaga et al.
A new livestock embryo model from a self-renewing source.
Selected by Carly Guiltinan. Read the preLight here.
Mechanical forces across compartments coordinate cell shape and fate transitions to generate tissue architecture by Clémentine Villeneuve et al.
It takes two to tango: coordinated mechanical contributions from epithelium and dermal fibroblasts help break symmetry for downgrowth and fate patterns in mouse hair follicles.
Selected by Sudeepa Nandi. Read the preLight here.
Functional synapses between small cell lung cancer and glutamatergic neurons by Anna Schmitt et al.
Lung cancer cells and neurons form a dangerous alliance: Schmitt and colleagues discover the formation of bona fide synapses between small cell lung cancer and neurons in their new study.
VAP spatially stabilizes dendritic mitochondria to locally fuel synaptic plasticity by Ojasee Bapat et al.
A novel player regulating mitochondrial stabilization in the dendrites: A proteomic screen uncovers the role of VAP in tethering mitochondria for continuous fuel supply during synaptic activity.
Selected by Kritika Mehta. Read the preLight here.
Gene complementation analysis suggests that dodder plants (Cuscuta spp.) do not depend on the host FT protein for flowering by Sina Mäckelmann et al.
Host-independent flowering of Cuscuta spp. reignites the search for a ‘Florigen’.
Selected by Gwendolyn K. Kirschner and Marc Somssich. Read the preLight here.
Restructuring of an asymmetric neural circuit during associative learning by Leo T.H. Tang et al.
The only constant is change – even in “hard-wired” C. elegans. Rewiring of an asymmetric neural circuit leads to associative salt-learning.
Selected by Chee Kiang Ewe. Read the preLight here.
Plasmodesmal connectivity in C4 Gynandropsis gynandra is induced by light and dependent on photosynthesis by Tina B. Schreier et al.
Light and photosynthesis trigger plasmodesmal formation in C4 dicotyledons.
Vesicles driven by dynein and kinesin exhibit directional reversals without external regulators by Ashwin I. D’Souza et al.
To move or not to move: A novel in vitro assay successfully recreates intracellular bidirectional cargo transport, laying the foundations for further understanding.
Selected by Divya Pathak. Read the preLight here.
