Distinct activities of Scrib module proteins organize epithelial polarity by Khoury & Bilder
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Lgl cortical dynamics are independent of binding to the Scrib-Dlg complex but require Dlg-dependent restriction of aPKC by Ventura et al.
Getting the upper hand: recent preprints describe how Lgl can be resistant to the action of aPKC with the help of ‘friends’ in the basolateral domain, whilst allowing aPKC to remain the dominant force apically.
Selected by Helen Zenner. Read the preLight here
Pick-ya actin: A method to purify actin isoforms with bespoke key post-translational modifications by Hatano et al.
Biochemically pure actin, now available with customised PTMs - a whole new playground for in vitro characterisation of actin behaviour.
Selected by Angika Basant. Read the preLight here
In situ cryo-electron tomography reveals filamentous actin within the microtubule lumen by Paul et al.
Letting the cat out of the bag: Cytoplasmic microtubules contain actin filaments.
Selected by Sina Knapp. Read the preLight here
Fully Unsupervised Probabilistic Noise2Void by Prakash et al.
Advancing image denoising: Improvements to Probabilistic Noise2Void (PN2V), a method to train convolutional neural networks for image denoising.
Selected by Mariana De Niz. Read the preLight here
ULK complex organization in autophagy by a C-shaped FIP200 N-terminal domain dimer by Shi et al.
The FIP200 N-terminal domain orchestrates assembly of the autophagy-inducing ULK complex.
Selected by Sandra Malmgren Hill. Read the preLight here
Cell lineage-dependent chiral actomyosin flows drive cellular rearrangements in early development by Pimpale et al.
Pimpale et al. show how chirality of cortical flows influences cell positioning throughout development.
Selected by Lars Hubatsch. Read the preLight here
Architectural RNA is required for heterochromatin organization by Thakur et al.
Cut the anchor: CUT&RUN.RNase identifies scaffolding of heterochromatic domains by RNA.
Selected by Ramona Jühlen. Read the preLight here
Apical Constriction Reversal upon Mitotic Entry Underlies Different Morphogenetic Outcomes of Cell Division by Ko et al.
The ins and outs of apical constriction: spatial patterns of mitosis within a contractile tissue regulate tissue invagination.
Nix induced mitochondrial fission, mitophagy, and myocyte insulin resistance are abrogated by PKA phosphorylation by da Silva Rosa et al.
Nix's function beyond mitophagy: role of a lipotoxicity-induced Nix in myocyte insulin resistance.
Selected by Sandra Franco Iborra. Read the preLight here
Direct ETTIN-auxin interaction controls chromatin state in gynoecium development by Kuhn et al.
A fresh face in auxin perception: the plant hormone auxin directly binds transcription factor ETTIN/ARF3 to de-repress transcription.
Selected by Martin Balcerowicz. Read the preLight here
Rab11A regulates the constitutive secretory pathway during Toxoplasma gondii invasion of host cells and parasite replication by Kannan et al.
Rab11A: a central player in the T. gondii constitutive secretory pathway, and in vital steps of the parasites’ journey into the target host cell.
Selected by Mariana De Niz. Read the preLight here
The Rab5-Rab11 endosomal pathway is required for BDNF-induced CREB transcriptional regulation in neurons by González et al.
BDNF/TrkB utilizes Rab5/Rab11 signaling endosomes to induce CREB phosphorylation and immediate gene expression in neurons.
Selected by Theresa Pohlkamp. Read the preLight here
GIV•Kindlin interaction is required for Kindlin-Mediated Integrin Recognition and Activation by Rohena et al.
GIV (Girdin) and Kindlin2 interaction boosts integrin activation.
Selected by Vibha Singh. Read the preLight here
Growth factor-mediated coupling between lineage size and cell fate choice underlies robustness of mammalian development by Saiz et al.
FGF4 signalling in the blastocyst: A simple system for an important binary cell fate decision.
Selected by Pierre Osteil and Irepan Salvador-Martinez. Read the preLight here
