The collective or individual migration of cells is an integral part of embryonic development. One key mechanism that cells use to reach their destination is to detect secreted or cell surface-presented molecules during the process of chemoattraction, which often operates with overlapping or antagonistic signal gradients. During migration of primordial germ cells in Drosophila, two enzymatic pathways control migration: the 3-hydroxy-3-methylglutaryl coenzyme A (Hmgcr) pathway attracts cells, whereas the Wunen enzymes promote repulsion. Now, Andrew Renault and colleagues (Kenwrick et al., 2019) test the range of the Hmgcr-dependent signal and the relationship between Hmgcr and Wunens. The authors show that the Hmgcr signal is cell contact independent and works in a dose-dependent fashion over distances above 50 µm. Importantly, concurrent overexpression of Hmgcr and Wunens pathways causes both attraction and repulsion of germ cells, arguing that both chemoattractants work simultaneously. In addition, the authors demonstrate that Hedgehog signalling is not required downstream of Hmgcr in germ cell attraction, in contrast to what had previously been proposed. This work advances the knowledge on the relationship of guidance cues in development and the long-standing question of the role of Hedgehog signalling in germ cell migration.