The cell wall regulates dynamics and size of plasma-membrane nanodomains in Arabidopsisby McKenna et al.

Imaging plasma membrane nanodomains in planta – and how they connect the extracellular cell wall to the intracellular cytoskeleton.

Selected by Marc Somssich. Read the preLight here

The modular mechanism of chromocenter formation in Drosophilaby Jagannathan et al.

Not just junk DNA: Satellite DNA and their cognate binding proteins form chromocenters to gather up chromosomes in one nucleus.

Selected by Maiko Kitaoka. Read the preLight here

Microtubules Gate Tau Condensation to Spatially Regulate Microtubule Functionsby Tan et al.


Kinetically distinct phases of tau on microtubules regulate kinesin motors and severing enzymesby Siahaan et al.

Islands on the highways! The microtubule-associated protein tau forms reversible islands on microtubules in vitro and modulates the behaviour of motor proteins and severing enzymes.

Selected by Satish Bodakuntla. Read the preLight here

A non-canonical arm of UPRERmediates longevity through ER remodeling and lipophagyby Daniele et al.

A neuronal stress response mediates longevity via cross-tissue signalling and upregulation of lipophagy.

Selected by Sandra Malmgren Hill. Read the preLight here.

Multi-color single molecule imaging uncovers extensive heterogeneity in mRNA decodingby Boersma et al.

When ribosomes take an alternative path: single-molecule sensor of translation reveals extensive heterogeneity in mRNA decoding.

Selected by Lorenzo Lafranchi. Read the preLight here

An F-actin shell ruptures the nuclear envelope by sorting pore-dense and pore-free membranes in meiosis of starfish oocytesby Wesolowska et al.

Watch out! F-actin spikes push against the nuclear envelope to separate nuclear pores and lead to nuclear envelope breakdown.

Selected by Maiko Kitaoka. Read the preLight here

Basal extrusion drives cell invasion and mechanical stripping of E-cadherinby Fadul et al.

Kicking out oncogenic cells may promote the spread of tumours.

Selected by William Hill. Read the preLight here

The coordination of terminal differentiation and cell cycle exit is mediated through the regulation of chromatin accessibilityby Ma et al.

Chromatin accessibility on the wing – insights into chromatin regulation of cell cycle exit

Selected by Gabriel Aughey. Read the preLight here

Retrieving High-Resolution Information from Disordered 2D Crystals by Single Particle Cryo-EMby Righetto et al.

2D crystals revisited – high resolution structures of the MloK1 ion channel are solved from “imperfect” 2D crystals by treating them as a single particle cryoEM sample.

Selected by David Wright. Read the preLight here

Suppressor of Fused controls perinatal expansion and quiescence of future dentate adult neural stem cellsby Pleasure et al.

What drives establishment of the quiescent neural stem cell pool in the dentate gyrus? The answer lies in the unusual activity of Sufu, a well-known regulator of Shh signalling.

Selected by Ekaterina Dvorianinova. Read the preLight here

A SOSEKI-based coordinate system interprets global polarity cues in Arabidopsisby Yoshida et al.

Subcellular signposts – or more? SOSEKI proteins are local outputs of the plant's global coordinate system.

Selected by Martin Balcerowicz. Read the preLight here.

Ribosomal DNA and the rDNA-binding protein Indra mediate non-random sister chromatid segregation in Drosophila male germline stem cellsby Watase and Yamashita

Sisters are not always identical: Chromosomal immortality in germline stem cells rests on rDNA loci and their binding partner Indra.

Selected by Maiko Kitaoka. Read the preLight here

Activation of intracellular transport by relieving KIF1C autoinhibitionby Siddiqui et al.

Straightening out: KIF1C is activated by the binding of scaffolding proteins PTPN21 or HOOK3

Selected by the Welburnlab. Read the preLight here

Structure of a cytochrome-based bacterial nanowireby Filman et al.

Will the world one day be powered by biological nanowires? Insights from the CryoEM structure of new electrically conductive pili may provide some answers

Selected by Amberley Stephens. Read the preLight here

The structural basis for release factor activation during translation termination revealed by time-resolved cryogenic electron microscopyby Fu et al.

Millisecond scale time-resolved cryoEM captures states in translational termination.

Selected by David Wright. Read the preLight here

Imaging mechanical properties of sub-micron ECM in live zebrafish using Brillouin microscopyby Bevilacqua et al.

How to measure ECM in living organisms with high-resolution but without labels? A new preprint from the Diz-Muñoz and Prevedel labs gives an answer.

Selected by Stephan Daetwyler. Read the preLight here

Unlimited genetic switches for cell-type specific manipulationby Garcia-Marques et al.

CaSSA: a new versatile system for intersectional gene expression enabling cell-type specific manipulations in vivo.

Selected by Rafael Almeida. Read the preLight here

Single molecule localization microscopy with autonomous feedback loops for ultrahigh precisionby Coelho et al.

Nanometer-accurate active drift correction for optical microscopy means crisper super-resolution images and allows ultra-precise distance measurements.

Selected by Sam Barnett. Read the preLight here

Phase transition and amyloid formation by a viral protein as an additional molecular mechanism of virus-induced cell toxicityby Salladini et al.

Phase transitions are everywhere – a viral protein is able to form amyloid-like hydrogels, contributing to cellular toxicity

Selected by Tessa Sinnige. Read the preLight here