The cell wall regulates dynamics and size of plasma-membrane nanodomains in Arabidopsis by McKenna et al.
Imaging plasma membrane nanodomains in planta – and how they connect the extracellular cell wall to the intracellular cytoskeleton.
The modular mechanism of chromocenter formation in Drosophila by Jagannathan et al.
Not just junk DNA: Satellite DNA and their cognate binding proteins form chromocenters to gather up chromosomes in one nucleus.
Microtubules Gate Tau Condensation to Spatially Regulate Microtubule Functions by Tan et al.
Kinetically distinct phases of tau on microtubules regulate kinesin motors and severing enzymes by Siahaan et al.
Islands on the highways! The microtubule-associated protein tau forms reversible islands on microtubules in vitro and modulates the behaviour of motor proteins and severing enzymes.
A non-canonical arm of UPRER mediates longevity through ER remodeling and lipophagy by Daniele et al.
A neuronal stress response mediates longevity via cross-tissue signalling and upregulation of lipophagy.
Multi-color single molecule imaging uncovers extensive heterogeneity in mRNA decoding by Boersma et al.
When ribosomes take an alternative path: single-molecule sensor of translation reveals extensive heterogeneity in mRNA decoding.
An F-actin shell ruptures the nuclear envelope by sorting pore-dense and pore-free membranes in meiosis of starfish oocytes by Wesolowska et al.
Watch out! F-actin spikes push against the nuclear envelope to separate nuclear pores and lead to nuclear envelope breakdown.
Basal extrusion drives cell invasion and mechanical stripping of E-cadherin by Fadul et al.
Kicking out oncogenic cells may promote the spread of tumours.
The coordination of terminal differentiation and cell cycle exit is mediated through the regulation of chromatin accessibility by Ma et al.
Chromatin accessibility on the wing – insights into chromatin regulation of cell cycle exit
Retrieving High-Resolution Information from Disordered 2D Crystals by Single Particle Cryo-EM by Righetto et al.
2D crystals revisited – high resolution structures of the MloK1 ion channel are solved from “imperfect” 2D crystals by treating them as a single particle cryoEM sample.
Suppressor of Fused controls perinatal expansion and quiescence of future dentate adult neural stem cells by Pleasure et al.
What drives establishment of the quiescent neural stem cell pool in the dentate gyrus? The answer lies in the unusual activity of Sufu, a well-known regulator of Shh signalling.
A SOSEKI-based coordinate system interprets global polarity cues in Arabidopsis by Yoshida et al.
Subcellular signposts – or more? SOSEKI proteins are local outputs of the plant's global coordinate system.
Ribosomal DNA and the rDNA-binding protein Indra mediate non-random sister chromatid segregation in Drosophila male germline stem cells by Watase and Yamashita
Sisters are not always identical: Chromosomal immortality in germline stem cells rests on rDNA loci and their binding partner Indra.
Activation of intracellular transport by relieving KIF1C autoinhibition by Siddiqui et al.
Straightening out: KIF1C is activated by the binding of scaffolding proteins PTPN21 or HOOK3
Structure of a cytochrome-based bacterial nanowire by Filman et al.
Will the world one day be powered by biological nanowires? Insights from the CryoEM structure of new electrically conductive pili may provide some answers
The structural basis for release factor activation during translation termination revealed by time-resolved cryogenic electron microscopy by Fu et al.
Millisecond scale time-resolved cryoEM captures states in translational termination.
Imaging mechanical properties of sub-micron ECM in live zebrafish using Brillouin microscopy by Bevilacqua et al.
How to measure ECM in living organisms with high-resolution but without labels? A new preprint from the Diz-Muñoz and Prevedel labs gives an answer.
Unlimited genetic switches for cell-type specific manipulation by Garcia-Marques et al.
CaSSA: a new versatile system for intersectional gene expression enabling cell-type specific manipulations in vivo.
Single molecule localization microscopy with autonomous feedback loops for ultrahigh precision by Coelho et al.
Nanometer-accurate active drift correction for optical microscopy means crisper super-resolution images and allows ultra-precise distance measurements.
Phase transition and amyloid formation by a viral protein as an additional molecular mechanism of virus-induced cell toxicity by Salladini et al.
Phase transitions are everywhere – a viral protein is able to form amyloid-like hydrogels, contributing to cellular toxicity