Cytoskeletal tension actively sustains the migratory T cell synaptic contactby Kumari et al.

Actin foci establish a tensile network that sustains the immunological synapse formed during T cell activation.

Selected by Tim Fessenden. Read the preLight here

Phase separation of zonula occludens proteins drives formation of tight junctionsby Beutel et al.

Phase separation strikes again! Zonula occludens proteins concentrate tight junction machinery by forming non-membrane enclosed compartments.

Selected by Abagael Lasseigne. Read the preLight here

OptiJ: Open-source optical projection tomography of large organ samplesby Ramirez et al.

A tool for all- OptiJ: an easy-to-assemble setup and freely available software as an incentive for widescale implementation of OPT.

Selected by Mariana De Niz. Read the preLight here

Molecularly distinct cores coexist inside stress granulesby Cirillo et al.

Getting to the core of cellular stress – superresolution microscopy reveals that core proteins G3BP1 and UBAP2L localise to distinct spots within stress granules.

Selected by Tessa Sinnige. Read the preLight here

Precisely control mitochondria with light to manipulate cell fate decisionby Ernst et al.

Using optogenetics, the ‘method of the decade’, to depolarise mitochondria.

Selected by Amberley Stephens. Read the preLight here

Rapid discovery of synthetic DNA sequences to rewrite endogenous T cell circuitsby Roth et al.

T-cells for everyone! A platform to screen functionality of novel DNA sequences in T-cells.

Selected by Pavithran Ravindran. Read the preLight here

Integrated Metabolomic and Transcriptomic Profiling Reveals Novel Activation-Induced Metabolic Networks in Human T cellsby Hiemer et al.

Feeding immunity: TCR stimulation leads to metabolic rewiring in human T cells to promote glucose and amino acid metabolism.

Selected by Jonny Coates. Read the preLight here

Modulation of neuronal resilience during aging by Hsp70/Hsp90/STI1 chaperone systemby Lackie et al.

The chaperone network as a highway to tissue resilience: the Hsp70/Hsp90 machinery prevents age-dependent hippocampal neurodegeneration.

Selected by Giuliana Clemente. Read the preLight here

Resolving the 3D landscape of transcription-linked mammalian chromatin foldingby Hsieh et al.

When smaller is better – Micro-C reveals transcription-linked chromatin architecture at very high resolution.

Selected by Clarice Hong. Read the preLight here

Adipocyte vesicles: ‘all-in-one’ packages that stimulate tumor mitochondrial metabolism and dynamicsby Clement et al.

Adipocytes donate packets of energy to melanoma cells to stimulate their mitochondrial metabolism and fuel cell motility.

Selected by Hannah Brunsdon. Read the preLight here

Molecular determinants of the Ska-Ndc80 interaction and their influence on microtubule tracking and force-couplingby Huis in ’t Veld et al.

Ndc80 and Ska: Shedding light on the molecular mechanisms of kinetochore-microtubule attachment and force-coupling in microtubule dynamicity.

Selected by Yasmin Lau. Read the preLight here

Intestinal peroxisomal fatty acid β-oxidation regulates neural serotonin signaling through a feedback mechanismby Bouagnon et al.

The Hunger Games: Peroxisomes are the central metabolic hubs that integrate metabolic status with the serotonergic signaling of feeding behaviour and fat metabolism.

Selected by Pablo Ranea Robles. Read the preLight here

Apicomplexan F-actin is required for efficient nuclear entry during host cell invasionby Del Rosario et al.

How do cells move bulky intracellular organelles through narrow spaces? Parasites might offer some answers to this exciting question.

Selected by Juan Quintana. Read the preLight here