Cytoskeletal tension actively sustains the migratory T cell synaptic contact by Kumari et al.
Actin foci establish a tensile network that sustains the immunological synapse formed during T cell activation.
Phase separation of zonula occludens proteins drives formation of tight junctions by Beutel et al.
Phase separation strikes again! Zonula occludens proteins concentrate tight junction machinery by forming non-membrane enclosed compartments.
OptiJ: Open-source optical projection tomography of large organ samples by Ramirez et al.
A tool for all- OptiJ: an easy-to-assemble setup and freely available software as an incentive for widescale implementation of OPT.
Molecularly distinct cores coexist inside stress granules by Cirillo et al.
Getting to the core of cellular stress – superresolution microscopy reveals that core proteins G3BP1 and UBAP2L localise to distinct spots within stress granules.
Precisely control mitochondria with light to manipulate cell fate decision by Ernst et al.
Using optogenetics, the ‘method of the decade’, to depolarise mitochondria.
Rapid discovery of synthetic DNA sequences to rewrite endogenous T cell circuits by Roth et al.
T-cells for everyone! A platform to screen functionality of novel DNA sequences in T-cells.
Integrated Metabolomic and Transcriptomic Profiling Reveals Novel Activation-Induced Metabolic Networks in Human T cells by Hiemer et al.
Feeding immunity: TCR stimulation leads to metabolic rewiring in human T cells to promote glucose and amino acid metabolism.
Modulation of neuronal resilience during aging by Hsp70/Hsp90/STI1 chaperone system by Lackie et al.
The chaperone network as a highway to tissue resilience: the Hsp70/Hsp90 machinery prevents age-dependent hippocampal neurodegeneration.
Resolving the 3D landscape of transcription-linked mammalian chromatin folding by Hsieh et al.
When smaller is better – Micro-C reveals transcription-linked chromatin architecture at very high resolution.
Adipocyte vesicles: ‘all-in-one’ packages that stimulate tumor mitochondrial metabolism and dynamics by Clement et al.
Adipocytes donate packets of energy to melanoma cells to stimulate their mitochondrial metabolism and fuel cell motility.
Molecular determinants of the Ska-Ndc80 interaction and their influence on microtubule tracking and force-coupling by Huis in ’t Veld et al.
Ndc80 and Ska: Shedding light on the molecular mechanisms of kinetochore-microtubule attachment and force-coupling in microtubule dynamicity.
Intestinal peroxisomal fatty acid β-oxidation regulates neural serotonin signaling through a feedback mechanism by Bouagnon et al.
The Hunger Games: Peroxisomes are the central metabolic hubs that integrate metabolic status with the serotonergic signaling of feeding behaviour and fat metabolism.
Apicomplexan F-actin is required for efficient nuclear entry during host cell invasion by Del Rosario et al.
How do cells move bulky intracellular organelles through narrow spaces? Parasites might offer some answers to this exciting question.