There was an error published in J. Cell Sci. 130, .
In panel C of Fig. 4 the arrows for +kinase and +HGF were pointing in the wrong direction. The correct panel is as shown below.
Potential roles of srGAPs in cadherin-based adhesion. (C) Model for HGF-dependent regulation of Rho activity at adherens junctions through cortactin and srGAP1 in Caco2 cells. Tyrosine-phosphorylated cortactin (yellow P) does not associate with srGAP1. Steady-state signaling at junctions may activate a kinase that maintains most cortactin in a phosphorylated state. HGF leads to dephosphorylation of cortactin, allowing recruitment of srGAP1. srGAP1 in turn decreases Rho activity via its GAP domain, thereby destabilizing cadherin-dependent cell–cell adhesion.
Potential roles of srGAPs in cadherin-based adhesion. (C) Model for HGF-dependent regulation of Rho activity at adherens junctions through cortactin and srGAP1 in Caco2 cells. Tyrosine-phosphorylated cortactin (yellow P) does not associate with srGAP1. Steady-state signaling at junctions may activate a kinase that maintains most cortactin in a phosphorylated state. HGF leads to dephosphorylation of cortactin, allowing recruitment of srGAP1. srGAP1 in turn decreases Rho activity via its GAP domain, thereby destabilizing cadherin-dependent cell–cell adhesion.
The authors apologise to the readers for any confusion that this error might have caused.
