The filamentous fungi Aspergillus nidulans grows in a highly polarized manner, making it a good model organism for studying the relationship between polarity and cell growth. On page 5400, Norio Takeshita and colleagues examine the dynamic behaviour of microtubules at the hyphal tip cortex of A. nidulans. The authors show that the cell-end marker protein TeaA is important for localising the growth machinery at the hyphal tips. TeaA is found in a central position at the tip, and this correlated with the convergence of the microtubule ends to a single point. In the absence of TeaA, however, the microtubules often reached the membrane off the centre of the apex. The authors next asked how TeaA is involved in the convergence of microtubules and established a possible functional connection between TeaA and AlpA, a conserved orthologue of the microtubule polymerase Dis1/CKAP5/XMAP215. AlpA localised at the microtubule plus-ends, and the authors' data indicated that AlpA might interact with TeaA after the plus-ends reach the tip cortex; AlpA also promoted microtubule growth up to sevenfold. Furthermore, the authors show that the catastrophe frequency of the microtubules was increased after the addition of the C-terminal region of TeaA. These findings suggest that the cooperation of TeaA and AlpA is important for the convergence of microtubules and for proper control of microtubule growth.
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IN THIS ISSUE| 01 December 2013
TeaA and AlpA: making friends and influencing tip growth
Online Issn: 1477-9137
Print Issn: 0021-9533
© 2013. Published by The Company of Biologists Ltd
J Cell Sci (2013) 126 (23): e2303.
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TeaA and AlpA: making friends and influencing tip growth. J Cell Sci 1 December 2013; 126 (23): e2303. doi:
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