Homophilic and heterophilic polycystin 1 interactions regulate E-cadherin recruitment and junction assembly in MDCK cells

We are welcoming submissions for our upcoming special issue: Cell Biology of Mitochondria. This issue will be coordinated by two Guest Editors: Ana J. Garcia-Saez (University of Cologne, Germany) and Heidi McBride (McGill University, Canada). Submission deadline: 1 October 2024.

In this Review, David Schlaepfer and colleagues summarise 30 years of focal adhesion kinase (FAK) research with a view of the ongoing clinical testing of small-molecule FAK inhibitors. The authors touch on how FAK plays an important signal integration role and ultimately functions to guide cellular behaviour. Additionally, the authors discuss how FAK inhibition might present a powerful tool to influence the physiological response to other therapeutic approaches.

Early-career researchers - working in an area covered by JCS - who would like to attend a microscopy training course, please apply. Deadline dates for 2024 applications: 7 September (decision by week commencing 8 October 2024); 22 November (decision by week commencing 16 December).

We are excited to invite you to a unique scientific conference, celebrating the 100-year anniversary of The Company of Biologists, and bringing together our different communities. The conference will incorporate the Spring Meetings of the BSCB and the BSDB, the JEB Symposium Sensory Perception in a Changing World and a DMM programme on antimicrobial resistance. Find out more and register your interest to join us in March 2025 in Liverpool, UK.

Read our interview with Rob Parton, a Cell Scientist to Watch, about his career journey leading him from the UK to the University of Queensland in Brisbane, Australia, the evolution of the membrane trafficking field and his advice for running a highly collaborative lab. As a Journal of Cell Science Editor, Rob brings to the journal his expertise in multiscale analysis of membrane function, membrane microdomains, lipid droplets and advanced microscopy techniques in cell biology.