Migfilin is a LIM-domain protein recruited to junctions that link cells with the extracellular matrix. It has multiple binding partners and appears to function as a scaffold that connects matrix-bound integrin-Mig-2 complexes with the actin-associated protein filamin. In a Research Article on p. 697, Chanyue Wu and co-workers reveal that migfilin also resides at cell-cell junctions. They find that it colocalizes with cadherin adhesion molecules and β-catenin at these sites. Moreover, they demonstrate it has a role there, since RNAi directed against migfilin disrupts the organization of these junctions and weakens endothelial cell-cell association. In a Commentary on p. 659, Wu goes on to discuss the broader roles of migfilin in cells. The protein represents a critical link between adhesion sites and the actin cytoskeleton. Consequently, it controls actin remodelling, cell morphology and motility. Furthermore, it can also translocate to the nucleus, where it interacts with transcription factors such as CSX/NKX2-5 to regulate gene expression and cell differentiation. Mutations in several migfilin binding partners are associated with severe human diseases (e.g. periventricular heterotopia and Kindler syndrome), underlining the importance of this protein for normal physiology.
Dual-purpose connector for cell junctions
Dual-purpose connector for cell junctions. J Cell Sci 15 February 2005; 118 (4): e401. doi:
Download citation file:
Advertisement
Cited by
Call for papers: Cell and Tissue Polarity
-PolarityCFP.png?versionId=4811)
We are welcoming submissions for our next special issue, which will focus on ‘Cell and tissue polarity’ and will be guest edited by David Bryant. Submission deadline: 15 July.
The Forest of Biologists

We are excited to announce the launch of The Forest of Biologists, a new biodiversity initiative created with support from the Woodland Trust, aiming to counteract nature loss and safeguard some of the most critically endangered ecosystems for future generations. For every Research Article and Review/Commentary article that is published in Journal of Cell Science, a native tree is planted in a forest in the UK.
Propose a new Workshop for 2025

Do you have an idea for a Workshop? We are now accepting proposals for our 2025 Biologists Workshops programme. As the scientific organiser, your involvement will be focused on the science. We'll take care of all the logistics. In 2025 we'll continue our efforts to diversify our Workshop programme and will be reserving one of our Workshops for an application from a Global South (GS) country to host an event overseas.
Editorial: Publishing where it matters
Editor-in-Chief Michael Way outlines Journal of Cell Science’s plans for the upcoming year and introduces Seema Grewal as our new Executive Editor.
Cell Scientists to Watch

As a community-focused journal, Journal of Cell Science is keen to support the next generation of cell biologists. Check out Cell Scientists to Watch, our interview series featuring talented researchers who have recently set up their own labs.