Simanis V. (2003). Events at the end of mitosis in the budding and fission yeasts. J. Cell Sci.116, 4263-4275.

Table 1 was omitted from both the online and print versions of this Commentary. We apologise for any inconvenience caused.

Table 1.

Nomenclature of SIN and MEN components and regulators

S. pombe SIN S. cerevisiae MEN Higher eukaryotes
Plo1   Protein kinase   CDC5   Polo-like kinases  
Cdc7   Protein kinase   CDC15   ?  
Spg1   GTPase   TEM1   ?  
Cdc11   Coiled-coil scaffold   NUD1   Centriolin  
Sid4   Coiled-coil scaffold   CNM67?   ?  
Sid1   Protein kinase   ?   ?  
Cdc14   Novel, binds Sid1p   ?   ?  
Sid2   Protein kinase   DBF2/DBF20   WARTS/LATS  
Mob1   Novel, binds Sid2p   MOB1   MOB1  
Cdc16   GAP   BUB2   GAPCENA?  
Byr4   GAP scaffold   BFA1   ?  
Dma1   FHA-RING finger   (YHR115c/YNL116w)   CHFR  
Zfs1   Novel   ?   ?  
Scw1   RNA binding   WHI3/4   
Par1   PP2A regulatory   (RTS1)   B′-regulatory subunit of PP2A  
Flp1   Phosphatase   CDC14   CDC14A/B  
?    NET1 Nucleolar protein   ?  
?    LTE1 Putative GEF   ?  
Spo12/Mts3    SPO12 Conserved   ?  
Cdc2   Protein kinase   CDC28 Protein kinase   CDK1 Protein kinase  
S. pombe SIN S. cerevisiae MEN Higher eukaryotes
Plo1   Protein kinase   CDC5   Polo-like kinases  
Cdc7   Protein kinase   CDC15   ?  
Spg1   GTPase   TEM1   ?  
Cdc11   Coiled-coil scaffold   NUD1   Centriolin  
Sid4   Coiled-coil scaffold   CNM67?   ?  
Sid1   Protein kinase   ?   ?  
Cdc14   Novel, binds Sid1p   ?   ?  
Sid2   Protein kinase   DBF2/DBF20   WARTS/LATS  
Mob1   Novel, binds Sid2p   MOB1   MOB1  
Cdc16   GAP   BUB2   GAPCENA?  
Byr4   GAP scaffold   BFA1   ?  
Dma1   FHA-RING finger   (YHR115c/YNL116w)   CHFR  
Zfs1   Novel   ?   ?  
Scw1   RNA binding   WHI3/4   
Par1   PP2A regulatory   (RTS1)   B′-regulatory subunit of PP2A  
Flp1   Phosphatase   CDC14   CDC14A/B  
?    NET1 Nucleolar protein   ?  
?    LTE1 Putative GEF   ?  
Spo12/Mts3    SPO12 Conserved   ?  
Cdc2   Protein kinase   CDC28 Protein kinase   CDK1 Protein kinase  

The table shows the main components of the SIN discussed in the text, and their equivalents in S. cerevisiae and higher eukaryotes. A lone question mark indicates that no convincing orthologue has been identified. A question mark after a gene name indicates significant homology, but no direct evidence for a role in cytokinesis or mitotic exit. The function of each gene product is indicated, where known. Abbreviations: FHA, forkhead-associated domain, RING finger, subclass of Zinc-fingers, associated with ubiquitin ligase activity. In S. cerevisiae MEN, brackets indicate that though these genes are orthologues of the S. pombe SIN protein, it is not known whether they are regulators of the MEN, or cytokinesis. Additional details are given in the text.

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2004