Correct positioning of the nucleus is critical in a variety of cell types, including nurse cells, intestinal brush-border cells, syncytia and all cells in which nuclear migration is required during development. Microtubules play an important part in nuclear positioning, as does the actin cytoskeleton. In a Commentary on p.211, Daniel Starr and Min Han discuss the importance of actin-based networks for nuclear anchorage, focusing on the roles of a novel family of proteins termed Syne/ANC-1. Studies in C. elegans have revealed that the UNC-84 and ANC-1 proteins are required for nuclear anchoring in the syncytial hypodermal cells. UNC-84 is a nuclear envelope protein, whereas ANC-1 is a huge evolutionarily conserved actin-binding protein. ANC-1 and its relatives, the Syne/ANC-1 family, appear to reside mainly in the cytoplasm, but they possess a C-terminal domain that localizes to the nuclear envelope. The majority of the protein, however, comprises repetitive stretches that could span >150 nm. Starr and Han propose that the C-terminal region is linked to UNC-84 in the nuclear membrane and anchors the nucleus to the actin cytoskeleton through this long, flexible domain.