Over recent years cadherins have emerged as a growing superfamily of molecules, and a complex picture of their structure and their biological functions is becoming apparent. Variation in their extracellular region leads to the large potential for recognition properties of this superfamily. This is demonstrated strikingly by the recently discovered FYN-binding CNR-protocadherins; these exhibit alternative expression of the extracellular portion, which could lead to distinct cell recognition in different neuronal populations, whereas their cytoplasmic part, and therefore intracellular interactions, is constant. Diversity in the cytoplasmic moiety of the cadherins imparts specificity to their interactions with cytoplasmic components; for example, classical cadherins interact with catenins and the actin filament network, desmosomal cadherins interact with catenins and the intermediate filament system and CNR-cadherins interact with the SRC-family kinase FYN. Recent evidence suggests that CNR-cadherins, 7TM-cadherins and T-cadherin, which is tethered to the membrane by a GPI anchor, all localise to lipid rafts, specialised cell membrane domains rich in signalling molecules. Originally thought of as cell adhesion molecules, cadherin superfamily molecules are now known to be involved in many biological processes, such as cell recognition, cell signalling, cell communication, morphogenesis, angiogenesis and possibly even neurotransmission.
REFERENCES
Adler
P. N.
, Charlton
J.
, Liu
J.
(1998
). Mutations in the cadherin superfamily member gene dachsous cause a tissue polarity phenotype by altering frizzled signaling.
Development
125
, 959
–968
Allen
E.
, Yu
Q. C.
, Fuchs
E.
(1996
). Mice expressing a mutant desmosomal cadherin exhibit abnormalities in desmosomes, proliferation, and epidermal differentiation.
J. Cell Biol
133
, 1367
–1382
Amagai
M.
(1999
). Autoimmunity against desmosomal cadherins in pemphigus.
J. Dermatol. Sci
20
, 92
–102
Arndt
K.
, Redies
C.
(1998
). Development of cadherin-defined parasagittal subdivisions in the embryonic chicken cerebellum.
J. Comp. Neurol
401
, 367
–381
Arnemann
J.
, Spurr
N. K.
, Wheeler
G. N.
, Parker
A. E.
, Buxton
R. S.
(1991
). Chromosomal assignment of the human genes coding for the major proteins of the desmosome junction, desmoglein DGI (DSG), desmocollins DGII/III (DSC), desmoplakins DPI/II (DSP), and plakoglobin DPIII (JUP).
Genomics
10
, 640
–645
Bach
T. L.
, Barsigian
C.
, Yaen
C. H.
, Martinez
J.
(1998
). Endothelial cell VE-cadherin functions as a receptor for the beta15-42 sequence of fibrin.
J. Biol. Chem
273
, 30719
–30728
Bienz
M.
(1999
). APC: the plot thickens.
Curr. Opin. Genet. Dev
9
, 595
–603
Bradley
R. S.
, Espeseth
A.
, Kintner
C.
(1998
). NF-protocadherin, a novel member of the cadherin superfamily, is required for Xenopus ectodermal differentiation.
Curr. Biol
8
, 325
–334
Brieher
W. M.
, Yap
A. S.
, Gumbiner
B. M.
(1996
). Lateral dimerization is required for the homophilic binding activity of C-cadherin.
J. Cell Biol
135
, 487
–496
Brown
J. D.
, Moon
R. T.
(1998
). Wnt signaling: why is everything so negative?.
Curr. Opin. Cell Biol
10
, 182
–187
Buratovich
M. A.
, Bryant
P. J.
(1997
). Enhancement of overgrowth by gene interactions in lethal(2)giant discs imaginal discs from Drosophila melanogaster.
Genetics
147
, 657
–670
Carmeliet
P.
, Lampugnani
M. G.
, Moons
L.
, Breviario
F.
, Compernolle
V.
, Bono
F.
, Balconi
G.
, Spagnuolo
R.
, Oostuyse
B.
, Dewerchin
M.
, et al. (1999
). Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis.
Cell
98
, 147
–157
Chae
J.
, Kim
M. J.
, Goo
J. H.
, Collier
S.
, Gubb
D.
, Charlton
J.
, Adler
P. N.
, Park
W. J.
(1999
). The Drosophila tissue polarity gene starry night encodes a member of the protocadherin family.
Development
126
, 5421
–5429
Chitaev
N. A.
, Troyanovsky
S. M.
(1997
). Direct Ca2+-dependent heterophilic interaction between desmosomal cadherins, desmoglein and desmocollin, contributes to cell-cell adhesion.
J. Cell Biol
138
, 193
–201
Chitaev
N. A.
, Troyanovsky
S. M.
(1998
). Adhesive but not lateral E-cadherin complexes require calcium and catenins for their formation.
J. Cell Biol
142
, 837
–846
Chitaev
N. A.
, Averbakh
A. Z.
, Troyanovsky
R. B.
, Troyanovsky
S. M.
(1998
). Molecular organization of the desmoglein-plakoglobin complex.
J. Cell Sci
111
, 1941
–1949
Christofori
G.
, Semb
H.
(1999
). The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene.
Trends Biochem. Sci
24
, 73
–76
Clark
H. F.
, Brentrup
D.
, Schneitz
K.
, Bieber
A.
, Goodman
C.
, Noll
M.
(1995
). Dachsous encodes a member of the cadherin superfamily that controls imaginal disc morphogenesis in Drosophila.
Genes Dev
9
, 1530
–1542
Collins
J. E.
, Legan
P. K.
, Kenny
T. P.
, MacGarvie
J.
, Holton
J. L.
, Garrod
D. R.
(1991
). Cloning and sequence analysis of desmosomal glycoproteins 2 and 3 (desmocollins): cadherin-like desmosomal adhesion molecules with heterogeneous cytoplasmic domains.
J. Cell Biol
113
, 381
–391
Coughlin
S. R.
(1994
). Expanding horizons for receptors coupled to G proteins: diversity and disease.
Curr. Opin. Cell Biol
6
, 191
–197
Cox
B.
, Hadjantonakis
A. K.
, Collins
J. E.
, Magee
A. I.
(2000
). Cloning and expression throughout mouse development of mfat1, a homologue of the Drosophila tumour suppressor gene fat.
Dev. Dynam
217
, 233
–240
Dejana
E.
, Bazzoni
G.
, Lampugnani
M. G.
(1999
). Vascular endothelial (VE)-cadherin: only an intercellular glue?.
Exp. Cell Res
252
, 13
–19
Doyle
D. D.
, Goings
G. E.
, Upshaw-Earley
J.
, Page
E.
, Ranscht
B.
, Palfrey
H. C.
(1998
). T-cadherin is a major glycophosphoinositol-anchored protein associated with noncaveolar detergent-insoluble domains of the cardiac sarcolemma.
J. Biol. Chem
273
, 6937
–6943
Dulabon
L.
, Olson
E. C.
, Taglienti
M. G.
, Eisenhuth
S.
, McGrath
B.
, Walsh
C. A.
, Kreidberg
J. A.
, Anton
E. S.
(2000
). Reelin binds alpha3beta1 integrin and inhibits neuronal migration.
Neuron
27
, 33
–44
Dunne
J.
, Hanby
A. M.
, Poulsom
R.
, Jones
T. A.
, Sheer
D.
, Chin
W. G.
, Da
S. M.
, Zhao
Q.
, Beverley
P. C.
, Owen
M. J.
(1995
). Molecular cloning and tissue expression of FAT, the human homologue of the Drosophila fat gene that is located on chromosome 4q34-q35 and encodes a putative adhesion molecule.
Genomics
30
, 207
–223
Fredette
B. J.
, Miller
J.
, Ranscht
B.
(1996
). Inhibition of motor axon growth by T-cadherin substrata.
Development
122
, 3163
–3171
Fukata
M.
, Nakagawa
M.
, Kuroda
S.
, Kaibuchi
K.
(1999
). Cell adhesion and Rho small GTPases.
J. Cell Sci
112
, 4491
–4500
Goldberg
M.
, Peshkovsky
C.
, Shifteh
A.
, Al-Awqati
Q.
(2000
). -Protocadherin, a novel developmentally regulated protocadherin with mucin-like domains.
J. Biol. Chem
275
, 24622
–24629
Gory-Faure
S.
, Prandini
M. H.
, Pointu
H.
, Roullot
V.
, Pignot-Paintrand
I.
, Vernet
M.
, Huber
P.
(1999
). Role of vascular endothelial-cadherin in vascular morphogenesis.
Development
126
, 2093
–2102
Gumbiner
B. M.
(1998
). Propagation and localization of Wnt signaling.
Curr. Opin. Genet. Dev
8
, 430
–435
Hadjantonakis
A. K.
, Sheward
W. J.
, Harmar
A. J.
, de Galan
L.
, Hoovers
J. M.
, Little
P. F.
(1997
). Celsr1, a neural-specific gene encoding an unusual seven-pass transmembrane receptor, maps to mouse chromosome 15 and human chromosome 22qter.
Genomics
45
, 97
–104
Hadjantonakis
A. K.
, Formstone
C. J.
, Little
P. F. R.
(1998
). mCelsr1 is an evolutionarily conserved seven-pass transmembrane receptor and is expressed during mouse embryonic development.
Mech. Dev
78
, 91
–95
Hakimelahi
S.
, Parker
H. R.
, Gilchrist
A. J.
, Barry
M.
, Li
Z.
, Bleackley
R. C.
, Pasdar
M.
(2000
). Plakoglobin regulates the expression of the anti-apoptotic protein BCL-2.
J. Biol. Chem
275
, 10905
–10911
Hatzfeld
M.
, Haffner
C.
, Schulze
K.
, Vinzens
U.
(2000
). The function of plakophilin 1 in desmosome assembly and actin filament organization.
J. Cell Biol
149
, 209
–222
Hirano
S.
, Yan
Q.
, Suzuki
S. T.
(1999
). Expression of a novel protocadherin, OL-protocadherin, in a subset of functional systems of the developing mouse brain.
J. Neurosci
19
, 995
–1005
Ho
Y. D.
, Joyal
J. L.
, Li
Z.
, Sacks
D. B.
(1999
). IQGAP1 integratesCa2+/calmodulin and Cdc42 signaling.
J. Biol. Chem
274
, 464
–70
Howell
B. W.
, Herrick
T. M.
, Cooper
J. A.
(1999
). Reelin-induced tryosine phosphorylation of disabled 1 during neuronal positioning.
Genes Dev
13
, 643
–8
Huber
O.
, Kemler
R.
, Langosch
D.
(1999
). Mutations affecting transmembrane segment interactions impair adhesiveness of E-cadherin.
J. Cell Sci
112
, 4415
–4423
Hunt
D. M.
, Sahota
V. K.
, Taylor
K.
, Simrak
D.
, Hornigold
N.
, Arnemann
J.
, Wolfe
J.
, Buxton
R. S.
(1999
). Clustered cadherin genes: a sequence-ready contig for the desmosomal cadherin locus on human chromosome 18.
Genomics
62
, 445
–455
Hyafil
F.
, Babinet
C.
, Jacob
F.
(1981
). Cell-cell interactions in early embryogenesis: a molecular approach to the role of calcium.
Cell
26
, 447
–454
Janes
P. W.
, Ley
S. C.
, Magee
A. I.
, Kabouridis
P. S.
(2000
). The role of lipid rafts in T cell antigen receptor (TCR) signalling.
Semin. Immunol
12
, 23
–34
Kaibuchi
K.
, Kuroda
S.
, Fukata
M.
, Nakagawa
M.
(1999
). Regulation of cadherin-mediated cell-cell adhesion by the Rho family GTPases.
Curr. Opin. Cell Biol
11
, 591
–596
Kim
S. H.
, Yamamoto
A.
, Bouwmeester
T.
, Agius
E.
, Robertis
E. M.
(1998
). The role of paraxial protocadherin in selective adhesion and cell movements of the mesoderm during Xenopus gastrulation.
Development
125
, 4681
–4690
Kim
S. H.
, Jen
W. C.
, De Robertis
E. M.
, Kintner
C.
(2000
). The protocadherin PAPC establishes segmental boundaries during somitogenesis in Xenopus embryos.
Curr. Biol
10
, 821
–830
King
I. A.
, Angst
B. D.
, Hunt
D. M.
, Kruger
M.
, Arnemann
J.
, Buxton
R. S.
(1997
). Hierarchical expression of desmosomal cadherins during stratified epithelial morphogenesis in the mouse.
Differentiation
62
, 83
–96
Koch
A. W.
, Bozic
D.
, Pertz
O.
, Engel
J.
(1999
). Homophilic adhesion by cadherins.
Curr. Opin. Struct. Biol
9
, 275
–281
Koch
P. J.
, Mahoney
M. G.
, Ishikawa
H.
, Pulkkinen
L.
, Uitto
J.
, Shultz
L.
, Murphy
G. F.
, Whitaker-Menezes
D.
, Stanley
J. R.
(1997
). Targeted disruption of the pemphigus vulgaris antigen (desmoglein 3) gene in mice causes loss of keratinocyte cell adhesion with a phenotype similar to pemphigus vulgaris.
J. Cell Biol
137
, 1091
–1102
Kodama
S.
, Ikeda
S.
, Asahara
T.
, Kishida
M.
, Kikuchi
A.
(1999
). Axin directly interacts with plakoglobin and regulates its stability.
J. Biol. Chem
274
, 27682
–27688
Kohmura
N.
, Senzaki
K.
, Hamada
S.
, Kai
N.
, Yasuda
R.
, Watanabe
M.
, Ishii
H.
, Yasuda
M.
, Mishina
M.
, Yagi
T.
(1998
). Diversity revealed by a novel family of cadherins expressed in neurons at a synaptic complex.
Neuron
20
, 1137
–1151
Kools
P.
, van Imschoot
G.
, van Roy
F.
(2000
). Characterization of three novel human cadherin genes (CDH7, CDH19, and CDH20) clustered on chromosome 18q22-q23 and with high homology to chicken cadherin-7 [In Process Citation].
Genomics
68
, 283
–295
Kowalczyk
A. P.
, Borgwardt
J. E.
, Green
K. J.
(1996
). Analysis of desmosomal cadherin-adhesive function and stoichiometry of desmosomal cadherin-plakoglobin complexes.
J. Invest. Dermatol
107
, 293
–300
Kowalczyk
A. P.
, Bornslaeger
E. A.
, Borgwardt
J. E.
, Palka
H. L.
, Dhaliwal
A. S.
, Corcoran
C. M.
, Denning
M. F.
, Green
K. J.
(1997
). The amino-terminal domain of desmoplakin binds to plakoglobin and clusters desmosomal cadherin-plakoglobin complexes.
J. Cell Biol
139
, 773
–784
Kowalczyk
A. P.
, Navarro
P.
, Dejana
E.
, Bornslaeger
E. A.
, Green
K. J.
, Kopp
D. S.
, Borgwardt
J. E.
(1998
). VE-cadherin and desmoplakin are assembled into dermal microvascular endothelial intercellular junctions:a pivotal role for plakoglobin in the recruitment of desmoplakin to intercellular junctions.
J. Cell Sci
111
, 3045
–3057
Kuroda
S.
, Fukata
M.
, Nakagawa
M.
, Fujii
K.
, Nakamura
T.
, Ookubo
T.
, Izawa
I.
, Nagase
T.
, Nomura
N.
, Tani
H.
, Shoji
I.
, Matsuura
Y.
, Yonehara
S.
, Kaibuchi
K.
(1998
). Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherin-mediated cell-cell adhesion.
Science
281
, 832
–835
Kwon
Y. T.
, Gupta
A.
, Zhou
Y.
, Nikolic
M.
, Tsai
L. H.
(2000
). Regulation of N-cadherin-mediated adhesion by the p35-Cdk5 kinase.
Curr. Biol
10
, 363
–372
Leckband
D.
, Sivasankar
S.
(2000
). Mechanism of homophilic cadherin adhesion [In Process Citation].
Curr. Opin. Cell Biol
12
, 587
–592
Li
Z.
, Kim
S. H.
, Higgins
J. M.
, Brenner
M. B.
, Sacks
D. B.
(1999
). IQGAP1 and calmodulin modulate E-cadherin function.
J. Biol. Chem
274
, 37885
–37892
Mahoney
P. A.
, Weber
U.
, Onofrechuk
P.
, Biessmann
H.
, Bryant
P. J.
, Goodman
C. S.
(1991
). The fat tumor suppressor gene in Drosophila encodes a novel member of the cadherin gene superfamily.
Cell
67
, 853
–868
Marcozzi
C.
, Burdett
I. D.
, Buxton
R. S.
, Magee
A. I.
(1998
). Coexpression of both types of desmosomal cadherin and plakoglobin confers strong intercellular adhesion.
J. Cell Sci
111
, 495
–509
Mathur
M.
, Goodwin
L.
, Cowin
P.
(1994
). Interactions of the cytoplasmic domain of the desmosomal cadherin Dsg1 with plakoglobin.
J. Biol. Chem
269
, 14075
–14080
Nakayama
M.
, Nakajima
D.
, Nagase
T.
, Nomura
N.
, Seki
N.
, Ohara
O.
(1998
). Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening.
Genomics
51
, 27
–34
North
A. J.
, Bardsley
W. G.
, Hyam
J.
, Bornslaeger
E. A.
, Cordingley
H. C.
, Trinnaman
B.
, Hatzfeld
M.
, Green
K. J.
, Magee
A. I.
, Garrod
D. R.
(1999
). Molecular map of the desmosomal plaque.
J. Cell Sci
112
, 4325
–4336
Nose
A.
, Nagafuchi
A.
, Takeichi
M.
(1987
). Isolation of placental cadherin cDNA: identification of a novel gene family of cell-cell adhesion molecules.
EMBO J
6
, 3655
–3661
Nunez
G.
, del Peso
L.
(1998
). Linking extracellular survival signals and the apoptotic machinery.
Curr. Opin. Neurobiol
8
, 613
–618
Ozawa
M.
, Kemler
R.
(1990
). Correct proteolytic cleavage is required for the cell adhesive function of uvomorulin.
J. Cell Biol
111
, 1645
–1650
Ozawa
M.
, Kemler
R.
(1998
). The membrane-proximal region of the E-cadherin cytoplasmic domain prevents dimerization and negatively regulates adhesion activity.
J. Cell Biol
142
, 1605
–1613
Palka
H. L.
, Green
K. J.
(1997
). Roles of plakoglobin end domains in desmosome assembly.
J. Cell Sci
110
, 2359
–2371
Parker
A. E.
, Wheeler
G. N.
, Arnemann
J.
, Pidsley
S. C.
, Ataliotis
P.
, Thomas
C. L.
, Rees
D. A.
, Magee
A. I.
, Buxton
R. S.
(1991
). Desmosomal glycoproteins II and III. Cadherin-like junctional molecules generated by alternative splicing.
J. Biol. Chem
266
, 10438
–10445
Pertz
O.
, Bozic
D.
, Koch
A. W.
, Fauser
C.
, Brancaccio
A.
, Engel
J.
(1999
). A new crystal structure, Ca2+ dependence and mutational analysis reveal molecular details of E-cadherin homoassociation.
EMBO J
18
, 1738
–1747
Peyrieras
N.
, Hyafil
F.
, Louvard
D.
, Ploegh
H. L.
, Jacob
F.
(1983
). Uvomorulin: a nonintegral membrane protein of early mouse embryo.
Proc. Nat. Acad. Sci. USA
80
, 6274
–6277
Philippova
M. P.
, Bochkov
V. N.
, Stambolsky
D. V.
, Tkachuk
V. A.
, Resink
T. J.
(1998
). T-cadherin and signal-transducing molecules co-localize in caveolin-rich membrane domains of vascular smooth muscle cells.
FEBS Lett
429
, 207
–210
Ponassi
M.
, Jacques
T. S.
, Ciani
L.
, ffrench Constant
C.
(1999
). Expression of the rat homologue of the Drosophila fat tumour suppressor gene.
Mech. Dev
80
, 207
–212
Ranscht
B.
, Dours-Zimmermann
M. T.
(1991
). T-cadherin, a novel cadherin cell adhesion molecule in the nervous system lacks the conserved cytoplasmic region.
Neuron
7
, 391
–402
Rickman
L.
, Simrak
D.
, Stevens
H. P.
, Hunt
D. M.
, King
I. A.
, Bryant
S. P.
, Eady
R. A.
, Leigh
I. M.
, Arnemann
J.
, Magee
A. I.
, Kelsell
D. P.
, Buxton
R. S.
(1999
). N-terminal deletion in a desmosomal cadherin causes the autosomal dominant skin disease striate palmoplantar keratoderma.
Hum. Mol. Genet
8
, 971
–976
Roberts
G. A.
, Burdett
I. D.
, Pidsley
S. C.
, King
I. A.
, Magee
A. I.
, Buxton
R. S.
(1998
). Antisense expression of a desmocollin gene in MDCK cells alters desmosome plaque assembly but does not affect desmoglein expression.
Eur. J. Cell Biol
76
, 192
–203
Sano
K.
, Tanihara
H.
, Heimark
R. L.
, Obata
S.
, Davidson
M.
, St John
T.
, Taketani
S.
, Suzuki
S.
(1993
). Protocadherins: a large family of cadherin-related molecules in central nervous system.
EMBO J
12
, 2249
–2256
Schuh
R.
, Vestweber
D.
, Riede
I.
, Ringwald
M.
, Rosenberg
U. B.
, Jackle
H.
, Kemler
R.
(1986
). Molecular cloning of the mouse cell adhesion molecule uvomorulin: cDNA contains a B1-related sequence.
Proc. Nat. Acad. Sci. USA
83
, 1364
–1368
Senzaki
K.
, Ogawa
M.
, Yagi
T.
(1999
). Proteins of the CNR family are multiple receptors for Reelin.
Cell
99
, 635
–647
Serpente
N.
, Marcozzi
C.
, Roberts
G. A.
, Bao
Q.
, Angst
B. D.
, Hirst
E. M. A.
, Burdett
I. D.
, Buxton
R. S.
, Magee
A. I.
(2000
). Extracellularly truncated Desmoglein 1 compromises desmosomes in MDCK cells.
Mol. Membr. Biol
17
, 175
–183
Shan
W. S.
, Tanaka
H.
, Phillips
G. R.
, Arndt
K.
, Yoshida
M.
, Colman
D. R.
, Shapiro
L.
(2000
). Functional cis-heterodimers of N-and R-cadherins.
J. Cell Biol
148
, 579
–590
Shapiro
L.
, Fannon
A. M.
, Kwong
P. D.
, Thompson
A.
, Lehmann
M. S.
, Grubel
G.
, Legrand
J. F.
, Als-Nielsen
J.
, Colman
D. R.
, Hendrickson
W. A.
(1995
). Structural basis of cell-cell adhesion by cadherins.
Nature
374
, 327
–337
Shapiro
L.
, Colman
D. R.
(1999
). The diversity of cadherins and implications for a synaptic adhesive code in the CNS.
Neuron
23
, 427
–330
Simons
K.
, Ikonen
E.
(1997
). Functional rafts in cell membranes.
Nature
387
, 569
–572
Simrak
D.
, Cowley
C. M.
, Buxton
R. S.
, Arnemann
J.
(1995
). Tandem arrangement of the closely linked desmoglein genes on human chromosome 18.
Genomics
25
, 591
–594
Smith
E. A.
, Fuchs
E.
(1998
). Defining the interactions between intermediate filaments and desmosomes.
J. Cell Biol
141
, 1229
–1241
Strehl
S.
, Glatt
K.
, Liu
Q. M.
, Glatt
H.
, Lalande
M.
(1998
). Characterization of two novel protocadherins (PCDH8 and PCDH9) localized on human chromosome 13 and mouse chromosome 14.
Genomics
53
, 81
–89
Sugino
H.
, Hamada
S.
, Yasuda
R.
, Tuji
A.
, Matsuda
Y.
, Fujita
M.
, Yagi
T.
(2000
). genomic organization of the family of CNR cadherin genes in mice and humans.
Genomics
63
, 75
–87
Takeda
H.
, Shimoyama
Y.
, Nagafuchi
A.
, Hirohashi
S.
(1999
). E-cadherin functions as a cis-dimer at the cell-cell adhesive interface in vivo.
Nature Struct. Biol
6
, 310
–312
Tamura
K.
, Shan
W. S.
, Hendrickson
W. A.
, Colman
D. R.
, Shapiro
L.
(1998
). Structure-function analysis of cell adhesion by neural (N-) cadherin.
Neuron
20
, 1153
–1163
Tang
L.
, Hung
C. P.
, Schuman
E. M.
(1998
). A role for the cadherin family of cell adhesion molecules in hippocampal long-term potentiation.
Neuron
20
, 1165
–1175
Tomschy
A.
, Fauser
C.
, Landwehr
R.
, Engel
J.
(1996
). Homophilic adhesion of E-cadherin occurs by a co-operative two-step interaction of N-terminal domains.
EMBO J
15
, 3507
–3514
Troyanovsky
R. B.
, Klingelhofer
J.
, Troyanovsky
S.
(1999
). Removal of calcium ions triggers a novel type of intercadherin interaction.
J. Cell Sci
112
, 4379
–4387
Ukropec
J. A.
, Hollinger
M. K.
, Salva
S. M.
, Woolkalis
M. J.
(2000
). SHP2 association with VE-cadherin complexes in human endothelial cells is regulated by thrombin.
J. Biol. Chem
275
, 5983
–5986
Usui
T.
, Shima
Y.
, Shimada
Y.
, Hirano
S.
, Burgess
R. W.
, Schwarz
T. L.
, Takeichi
M.
, Uemura
T.
(1999
). Flamingo, a seven-pass transmembrane cadherin, regulates planar cell polarity under the control of Frizzled.
Cell
98
, 585
–595
Vasioukhin
V.
, Bauer
C.
, Yin
M.
, Fuchs
E.
(2000
). Directed actin polymerization is the driving force for epithelial cell-cell adhesion.
Cell
100
, 209
–219
Vestal
D. J.
, Ranscht
B.
(1992
). Glycosylphosphatidylinositol—anchored T-cadherin mediates calcium-dependent, homophilic cell adhesion.
J. Cell Biol
119
, 451
–461
Walsh
F. S.
, Barton
C. H.
, Putt
W.
, Moore
S. E.
, Kelsell
D.
, Spurr
N.
, Goodfellow
P. N.
(1990
). N-cadherin gene maps to human chromosome 18 and is not linked to the E-cadherin gene.
J. Neurochem
55
, 805
–812
Wheeler
G. N.
, Buxton
R. S.
, Parker
A. E.
, Arnemann
J.
, Rees
D. A.
, King
I. A.
, Magee
A. I.
(1991
). Desmosomal glycoproteins I, II and III: novel members of the cadherin superfamily.
Biochem. Soc. Trans
19
, 1060
–1064
Witcher
L. L.
, Collins
R.
, Puttagunta
S.
, Mechanic
S. E.
, Munson
M.
, Gumbiner
B.
, Cowin
P.
(1996
). Desmosomal cadherin binding domains of plakoglobin.
J. Biol. Chem
271
, 10904
–10909
Wu
Q.
, Maniatis
T.
(1999
). A striking organization of a large family of human neural cadherin-like cell adhesion genes.
Cell
97
, 779
–790
Wu
Q.
, Maniatis
T.
(2000
). Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes [In Process Citation].
Proc. Nat. Acad. Sci. USA
97
, 3124
–3129
Yagi
T.
(1999
). Molecular mechanisms of Fyn-tyrosine kinase for regulating mammalian behaviors and ethanol sensitivity.
Biochem. Pharmacol
57
, 845
–850
Yamagata
K.
, Andreasson
K. I.
, Sugiura
H.
, Maru
E.
, Dominique
M.
, Irie
Y.
, Miki
N.
, Hayashi
Y.
, Yoshioka
M.
, Kaneko
K.
, Kato
H.
, Worley
P. F.
(1999
). Arcadlin is a neural activity-regulated cadherin involved in long term potentiation.
J. Biol. Chem
274
, 19473
–19479
Yamamoto
A.
, Amacher
S. L.
, Kim
S. H.
, Geissert
D.
, Kimmel
C. B.
, De Robertis
E. M.
(1998
). Zebrafish paraxial protocadherin is a downstream target of spadetail involved in morphogenesis of gastrula mesoderm.
Development
125
, 3389
–3397
Yap
A. S.
, Brieher
W. M.
, Gumbiner
B. M.
(1997
). Molecular and functional analysis of cadherin-based adherens junctions.
Annu. Rev. Cell Dev. Biol
13
, 119
–146
Yap
A. S.
, Brieher
W. M.
, Pruschy
M.
, Gumbiner
B. M.
(1997
). Lateral clustering of the adhesive ectodomain: a fundamental determinant of cadherin function.
Curr. Biol
7
, 308
–315
Yap
A. S.
, Niessen
C. M.
, Gumbiner
B. M.
(1998
). The juxtamembrane region of the cadherin cytoplasmic tail supports lateral clustering, adhesive strengthening, and interaction with p120ctn.
J. Cell Biol
141
, 779
–789
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