The ER-Golgi intermediate compartment (ERGIC) marker ERGIC-53 is a mannose-specific membrane lectin operating as a cargo receptor for the transport of glycoproteins from the ER to the ERGIC. Lack of functional ERGIC-53 leads to a selective defect in secretion of glycoproteins in cultured cells and to hemophilia in humans. Beyond its interest as a transport receptor, ERGIC-53 is an attractive probe for studying numerous aspects of protein trafficking in the secretory pathway, including traffic routes, mechanisms of anterograde and retrograde traffic, retention of proteins in the ER, and the function of the ERGIC. Understanding these fundamental processes of cell biology will be crucial for the elucidation and treatment of many inherited and acquired diseases, such as cystic fibrosis, Alzheimer's disease and viral infections.
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JOURNAL ARTICLE| 15 February 2000
ERGIC-53 and traffic in the secretory pathway
Online Issn: 1477-9137
Print Issn: 0021-9533
© 2000 by Company of Biologists
J Cell Sci (2000) 113 (4): 587–596.
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H.P. Hauri, F. Kappeler, H. Andersson, C. Appenzeller; ERGIC-53 and traffic in the secretory pathway. J Cell Sci 15 February 2000; 113 (4): 587–596. doi: https://doi.org/10.1242/jcs.113.4.587
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