Shank proteins make up a new family of scaffold proteins recently identified through their interaction with a variety of membrane and cytoplasmic proteins. Shank polypeptides contain multiple sites for protein-protein interaction, including ankyrin repeats, an SH3 domain, a PDZ domain, a long proline-rich region, and a SAM domain. Binding partners for most of these domains have been identified: for instance, the PDZ domain of Shank proteins interacts with GKAP (a postsynaptic-density protein) as well as several G-protein-coupled receptors. The specific localization of Shank proteins at postsynaptic sites of brain excitatory synapses suggests a role for this family of proteins in the organization of cytoskeletal/ signaling complexes at specialized cell junctions.
Skip Nav Destination
JOURNAL ARTICLE| 01 June 2000
The Shank family of scaffold proteins
M. Sheng ,
Online Issn: 1477-9137
Print Issn: 0021-9533
© 2000 by Company of Biologists
J Cell Sci (2000) 113 (11): 1851–1856.
- Views Icon Views
- PDF LinkPDF
- Share Icon Share
- Search Site
M. Sheng, E. Kim; The Shank family of scaffold proteins. J Cell Sci 1 June 2000; 113 (11): 1851–1856. doi: https://doi.org/10.1242/jcs.113.11.1851
Download citation file: