REFERENCES

Balvay
L.
,
Libri
D.
,
Gallego
M.
,
Fiszman
M. Y.
(
1992
).
Intronic sequence with both negative and positive effects on the regulation of alternative transcripts of the chickentropomyosin transcripts.
Nucl. Acids Res
20
,
3987
3992
Ben-David
Y.
,
Bani
M. R.
,
Chabot
B.
,
De Koven
A.
,
Bernstein
A.
(
1992
).
Retroviral insertions downstream of the heterogeneous nuclear ribonucleoprotein A1 gene in erythroleukemia cells: evidence that A1 is not essential for cell growth.
Mol. Cell. Biol
12
,
4449
4455
Bennett
M.
,
Michaud
S.
,
Kingston
J.
,
Reed
R.
(
1992
).
Protein components specifically associated with prespliceosome and spliceosome complexes.
Genes Dev
6
,
1986
2000
Bennett
M.
,
Piñol-Roma
S.
,
Staknis
D.
,
Dreyfuss
G.
,
Reed
R.
(
1992
).
Differential binding of heterogeneous nuclear ribonucleoproteins to mRNA precursors prior to spliceosome assembly in vitro.
Mol. Cell. Biol
12
,
3165
3175
Black
D. L.
(
1992
).
Activation of c-src neuron-specific splicing by an unusual RNA element in vivo and in vitro.
Cell
69
,
795
807
Buvoli
M.
,
Cobianchi
F.
,
Biamonti
G.
,
Riva
S.
(
1990
).
Recombinant hnRNP protein A1 and its N-terminal domain show preferential affinity for oligodeoxynucleotides.
Nucl. Acids Res
18
,
6595
6604
Chabot
B.
,
Frappier
D.
,
La Branche
H.
(
1992
).
Differential ASF/SF2 activity in extracts from normal WI38 and transformed WI38VA13 cells.
Nucl. Acids Res
20
,
5197
5204
Cooper
T. A.
,
Ordahl
C. P.
(
1989
).
Nucleotide substitutions within the cardiac troponin T alternative exon disrupt pre-mRNA splicing.
Nucl. Acids Res
17
,
7905
7921
Cote
G. J.
,
Nguyen
I. N.
,
Lips
C. J. M.
,
Berget
S. M.
,
Gagel
R. F.
(
1991
).
Validation of an in vitro RNA-processing system for CT/CGRP precursor mRNA.
Nucl. Acids Res
19
,
3601
3606
Cote
G. J.
,
Stolow
D. T.
,
Peleg
S.
,
Berget
S. M.
,
Gagel
R. F.
(
1992
).
Identification of exon sequences and an exon binding protein involved in alternative RNA splicing of calcitonin/CGRP.
Nucl. Acids Res
20
,
2361
2366
Dignam
J. D.
,
Lebovitz
R. M.
,
Roeder
R. G.
(
1983
).
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei.
Nucl. Acids Res
11
,
1475
1489
Dominski
Z.
,
Kole
R.
(
1992
).
Cooperation of pre-mRNA sequence elements in splice site selection.
Mol. Cell. Biol
12
,
2108
2114
Fu
X.-Y.
,
Manley
J. L.
(
1987
).
Factors influencing alternative splice site utilization in vivo.
Mol. Cell. Biol
7
,
738
748
Fu
X.-D.
,
Maniatis
T.
(
1990
).
Factor required for mammalian spliceosome assembly is localized to discrete regions in the nucleus.
Nature
343
,
437
441
Fu
X.-D.
,
Mayeda
A.
,
Maniatis
T.
,
Krainer
A. R.
(
1992
).
General splicing factors SF2 and SC35 have equivalent activities in vitro and both affect alternative 5and 3 splice site selection.
Proc. Nat. Acad. Sci. USA
89
,
11224
11228
Furneaux
H. M.
,
Perkins
K. K.
,
Freyer
G.
,
Arenas
J.
,
Hurwitz
J.
(
1985
).
Isolation and characterization of two fractions from HeLa cells required for mRNA splicing in vitro.
Proc. Nat. Acad. Sci. USA
82
,
4351
4355
Garcia-Blanco
M. A.
,
Jamison
S. F.
,
Sharp
P. A.
(
1989
).
Identification and purification of a 62,000-dalton protein that binds specifically to the polypyrimidine tract of introns.
Genes Dev
3
,
1874
1886
Gattoni
R.
,
Schmitt
P.
,
Stevenin
J.
(
1988
).
In vitro splicing of adenovirus E1A transcripts: characterization of novel reactions and o multiple branch points abnormally far from the 3splice site.
Nucl. Acids Res
16
,
2389
2409
Ge
H.
,
Manley
J. L.
(
1990
).
A protein factor, ASF, controls cell-specific alternative splicing of SV40 early pre-mRNA in vitro.
Cell
62
,
25
34
Gerke
V.
,
Steitz
J. A.
(
1986
).
A protein associated with small nuclear ribonucleoprotein particles recognizes the 3splice site of premessenger RNA.
Cell
47
,
973
984
Ghetti
A.
,
Piñol-Roma
S.
,
Michael
W. M.
,
Morandi
C.
,
Dreyfuss
G.
(
1992
).
hnRNP I, the polypyrimidine tract-binding protein: distinct nuclear localization and association with hnRNAs.
Nucl. Acids Res
20
,
3671
3678
Gil
A.
,
Sharp
P. A.
,
Jamison
S. F.
,
Garcia-Blanco
M. A.
(
1991
).
Characterization of cDNAs encoding the polypyrimidine tract-binding protein.
Genes Dev
5
,
1224
1236
Goux-Pelletan
M.
,
Libri
D.
,
d'Aubenton-Carafa
Y.
,
Fiszman
M.
,
Brody
E.
,
Marie
J.
(
1990
).
In vitro splicing of mutually exclusive exons from the chicken-tropomyosin gene: role of the branch point location and very long pyrimidine stretch.
EMBO J
9
,
241
249
Graham
I. R.
,
Hamshere
M.
,
Eperon
I. C.
(
1992
).
Alternative Splicing of a human-tropomyosin muscle-specific exon: identification of determining sequences.
Mol. Cell. Biol
12
,
3872
3882
Green
M. R.
(
1991
).
Biochemical mechanisms of constitutive and regulated pre-mRNA splicing.
Annu. Rev. Cell Biol
7
,
559
599
Guo
W.
,
Mulligan
G. J.
,
Wormsley
S.
,
Helfman
D. M.
(
1991
).
Alternative splicing of-tropomyosin pre-mRNA: cis-acting elements and cellular factors that block the use of a skeletal muscle exon in nonmuscle cells.
Genes Dev
5
,
2096
2107
Guthrie
C.
(
1991
).
Messenger RNA splicing in yeast: clues to why the spliceosome is a ribonucleoprotein.
Science
253
,
157
163
Hampson
R. K.
,
LaFollette
L.
,
Rottman
F. M.
(
1989
).
Alternative processing of bovine growth mRNA is influenced by downstream exon sequences.
Mol. Cell. Biol
9
,
1604
1610
Hartmuth
K.
,
Barta
A.
(
1988
).
Unusual branch point selection of human growth hormone pre-mRNA.
Mol. Cell. Biol
8
,
2011
2020
Helfman
D. M.
,
Ricci
W. M.
(
1989
).
Branch point selection in alternative splicing of tropomyosin pre-mRNAs.
Nucl. Acids Res
17
,
5633
5650
Helfman
D. M.
,
Roscigno
R. F.
,
Mulligan
G. J.
,
Finn
L. A.
,
Weber
K. S.
(
1990
).
Identification of two distinct intron elements involved in alternative splicing of-tropomyosin pre-mRNA.
Genes Dev
4
,
98
110
Hoffman
B. E.
,
Grabowski
P. J.
(
1992
).
U1 snRNP targets an essential splicing factor, U2AF65, to the 3splice site by a network of interactions spanning the exon.
Genes Dev
6
,
2554
2568
Huh
G. S.
,
Hynes
R. O.
(
1993
).
The anatomy of an alternatively spliced region of the rat fibronectin gene.
Mol. Cell. Biol
13
,
5301
5314
Inoue
K.
,
Hoshijima
K.
,
Sakamotot
H.
,
Shimura
Y.
(
1990
).
Binding of the Drosophila sex-lethal gene product to the alternative splice site of transformer primary transcript.
Nature
344
,
461
463
Jamison
S. F.
,
Crow
A.
,
Garcia-Blanco
M. A.
(
1992
).
The spliceosome assembly pathway in mammalian extracts.
Mol. Cell. Biol
12
,
4279
4287
Kim
Y.-J.
,
Zuo
P.
,
Manley
J. L.
,
Baker
B. S.
(
1992
).
The Drosophila RNA-binding protein RBP1 is localized to transcriptionally active sites of chromosomes and shows functional similarity to human splicing factor ASF/SF2.
Genes Dev
6
,
2569
2579
Krainer
A. R.
,
Maniatis
T.
(
1985
).
Multiple factors including the smallnuclear ribonucleoproteins U1 and U2 are necessary for pre-mRNA splicing.
Cell
42
,
725
736
Krainer
A. R.
,
Conway
G. C.
,
Kozak
D.
(
1990
).
The essential pre-mRNA splicing factor SF2 influences 5splice site selection by activating proximal sites.
Cell
62
,
35
42
Krainer
A. R.
,
Conway
G. C.
,
Kozak
D.
(
1990
).
Purification and characterization of pre-mRNA splicing factor SF2 from HeLa cells.
Genes Dev
4
,
1158
1171
Krämer
A.
,
Frick
M.
,
Keller
W.
(
1987
).
Separation of multiple components of HeLa cell nuclear extracts required for pre-messenger RNA splicing.
J. Biol. Chem
262
,
17630
17640
Krämer
A.
,
Utans
U.
(
1991
).
Three protein factors (SF1, SF3, and U2AF) function in pre-mRNA splicing complex formation in addition to snRNPs.
EMBO J
10
,
1503
1509
Kuo
H.-C.
,
Nasim
F. H.
,
Grabowski
P. J.
(
1991
).
Control of alternative splicing by the differential binding of U1 small nuclear ribonucleoprotein particle.
Science
251
,
1045
1050
La Branche
H.
,
Frappier
D.
,
Chabot
B.
(
1991
).
Proteolysis of splicing factors during rat and monkey cell fractionation.
Nucl. Acids Res
19
,
4509
4514
Maniatis
T.
(
1991
).
Mechanisms of alternative pre-mRNA splicing.
Science
251
,
33
34
Mardon
H. J.
,
Sebastio
G.
,
Baralle
F. E.
(
1987
).
A role for exon sequences in alternative splicing of the human fibronectin gene.
Nucl. Acids Res
15
,
7725
7733
Mattaj
I. W.
,
Hamm
J.
(
1989
).
Regulated splicing in early development and stage-specific U snRNPs.
Development
105
,
183
189
Mattaj
I. W.
(
1993
).
RNA recognition: A family matter?.
Cell
73
,
837
840
Mayeda
A.
,
Krainer
A. R.
(
1992
).
Regulation of alternative pre-mRNA splicing by hnRNP A1 and splicing factor SF2.
Cell
68
,
365
375
Mayeda
A.
,
Zahler
A. M.
,
Krainer
A. R.
,
Roth
M. B.
(
1992
).
Two members of a conserved family of nuclear phophoproteins are involved in pre-mRNA splicing.
Proc. Nat. Acad. Sci. USA
89
,
1301
1304
Mayeda
A.
,
Helfman
D. M.
,
Krainer
A. R.
(
1993
).
Modulation of exon skipping and inclusion by heterogeneous nuclear ribonucleoprotein A1 and pre-mRNA splicing factor SF2/ASF.
Mol. Cell. Biol
13
,
2993
3001
McKeown
M.
(
1992
).
Alternative mRNA splicing.
Annu. Rev. Cell Biol
8
,
133
55
McKeown
M.
(
1993
).
The role of small nuclear RNAs in RNA splicing.
Curr. Opin. Cell Biol
5
,
448
454
Mullen
M. P.
,
Smith
C. W. J.
,
Patton
J. G.
,
Nadal-Ginard
B.
(
1991
).
-tropomyosin mutually exclusive exon selection: competition between branchpoint/polypyrimidine tracts determines default exon choice.
Genes Dev
5
,
642
655
Mulligan
G. J.
,
Guo
W.
,
Wormsley
S.
,
Helfman
D. M.
(
1992
).
Polypyrimidine tract binding protein interacts with sequences involved in alternative splicing of-tropomyosin pre-mRNA.
J. Biol. Chem
267
,
25480
25487
Noble
J. C. S.
,
Pan
Z.-Q.
,
Prives
C.
,
Manley
J. L.
(
1987
).
Splicing of SV40 early pre-mRNA to large T and small t mRNAs utilizes different patterns of lariat branch sites.
Cell
50
,
227
236
Norton
P. A.
,
Hynes
R. O.
(
1990
).
In vitro splicing of fibronectin pre-RNAs.
Nucl. Acids Res
18
,
4089
4097
Norton
P. A.
,
Hynes
R. O.
(
1993
).
Characterization of HeLa nuclear factors which interact with a conditionally processed rat fibronectin pre-mRNA.
Biochem. Biophys. Res. Commun
195
,
215
221
Parker
R.
,
Siliciano
P. G.
,
Guthrie
C.
(
1987
).
Recognition of the TACTAAC box during mRNa splicing in yeast involves base pairing to the U2-like snRNA.
Cell
49
,
229
239
Patton
J. G.
,
Mayer
S. A.
,
Tempst
P.
,
Nadal-Ginard
B.
(
1991
).
Characterization and molecular cloning of polypyrimidine tract-bindingprotein: a component of a complex necessary for pre-mRNA splicing.
Genes Dev
5
,
1237
1251
Patton
J. G.
,
Porro
E. B.
,
Galceran
J.
,
Tempst
P.
,
Nadal-Ginard
B.
(
1993
).
Cloning and characterization of PSF, a novel pre-mRNa splicing factor.
Genes Dev
7
,
393
406
Reddy
R.
(
1988
).
Compilation of small RNA sequences.
Nucl. Acids Res
16
,
71
–.
Robberson
B. L.
,
Cote
G. J.
,
Berget
S. M.
(
1990
).
Exon definition may facilitate splice site selection in RNAs with multiple exons.
Mol. Cell. Biol
10
,
84
94
Roesser
J. R.
,
Liittschwager
K.
,
Leff
S. E.
(
1993
).
Regulation of tissue-specific splicing of the calcitonin/calcitonin gene-related peptide gene by RNA-binding proteins.
J. Biol. Chem
268
,
8366
8375
Roth
M. B.
,
Zahler
A. M.
,
Stolk
J. A.
(
1991
).
A conserved family of nuclear phosphoproteins localized to sites of polymerase II transcription.
J. Cell Biol
115
,
587
596
Ruby
S. W.
,
Abelson
J.
(
1991
).
Pre-mRNA splicing in yeast.
Trends Genet
7
,
79
85
Ruskin
B.
,
Zamore
P. D.
,
Green
M. R.
(
1988
).
A factor, U2AF, is required for U2 snRNP binding and splicing complex assembly.
Cell
52
,
207
219
Seraphin
B.
,
Kretzner
L.
,
Rosbash
M.
(
1988
).
A u1 snRNA:pre-mRNA base pairing interaction is required early in yeast spliceosome assembly but does not uniquely define the 5cleavage site.
EMBO J
7
,
2533
2538
Sharp
P. A.
(
1987
).
Splicing of messenger RNA precursors.
Science
235
,
766
771
Siebel
C. W.
,
Rio
D. C.
(
1990
).
Regulated splicing of the Drosophila P transposable element third intron in vitro: somatic repression.
Science
248
,
1200
1208
Siliciano
P. G.
,
Guthrie
C.
(
1988
).
5splice site selection in yeast: genetic alterations in base-pairing with U1 reveal additional requirements.
Genes Dev
2
,
1258
1267
Smith
C. W. J.
,
Nadal-Ginard
B.
(
1989
).
Mutually exclusive splicing of-tropomyosin exons enforced by an unusual lariat branch point location: Implications for constitutive splicing.
Cell
56
,
749
758
Smith
C. W. J.
,
Patton
J. G.
,
Nadal-Ginard
B.
(
1989
).
Alternative splicing in the control of gene expression.
Annu. Rev. Genet
23
,
527
577
Sosnowski
B. A.
,
Belote
J. M.
,
McKeown
M.
(
1989
).
Sex-specific alternative splicing of RNA from the transformer gene results from sequence-dependent splice site blockage.
Cell
58
,
449
459
Steitz
J. A.
(
1992
).
Splicing takes a Holliday.
Science
257
,
888
889
Stolow
D. T.
,
Berget
S. M.
(
1991
).
Identification of nuclear proteins that specifically bind to RNAs containing 5splices sites.
Proc. Nat. Acad. Sci. USA
88
,
320
324
Streuli
M.
,
Saito
H.
(
1989
).
Regulation of tissue-specific alternative splicing: exon-specific cis-elements govern the splicing of leukocyte common antigen pre-mRNA.
EMBO J
8
,
787
796
Swanson
M. S.
,
Dreyfuss
G.
(
1988
).
RNA binding specificity of hnRNP proteins: a subset bind to the 3end of introns.
EMBO J
7
,
3519
3529
Tacke
R.
,
Goridis
C.
(
1991
).
Alternative splicing in the neural cell adhesion molecule pre-mRNA: regulation of exon 18 skipping depends on the 5-splice site.
Genes Dev
5
,
1416
1429
Tazi
J.
,
Alibert
C.
,
Temsamani
J.
,
Reveillaud
I.
,
Cathala
G.
,
Brunel
C.
,
Jeanteur
P.
(
1986
).
A protein that specifically recognizes the 3splice site of mammalian pre-mRNA introns is associated with a small nuclear ribonucleoprotein.
Cell
47
,
755
766
Tazi
J.
,
Kornstädt
U.
,
Rossi
F.
,
Jeanteur
P.
,
Cathala
G.
,
Brunel
C.
,
Luhrmann
R.
(
1993
).
Thiophosphorylation of U1-70K protein inhibits pre-mRNA splicing.
Nature
363
,
283
286
Valcárcel
J.
,
Singh
R.
,
Zamore
P. D.
,
Green
M. R.
(
1993
).
The protein Sex-lethal antagonizes the splicing factor U2AF to regulate alternative splicing of transformer pre-mRNA.
Nature
362
,
171
175
Wang
J.
,
Pederson
T. A.
(
1990
).
62,000 Molecular weight spliceosome protein crosslinks to the intron polypyrimidine tract.
Nucl. Acids Res
18
,
5995
6001
Wassarman
D. A.
,
Steitz
J. A.
(
1992
).
Interactions of small nuclear RNA's with precursor messenger RNA during in vitro splicing.
Science
257
,
1918
1925
Watakabe
A.
,
Tanaka
K.
,
Shimura
Y.
(
1993
).
The role of exon sequences in splice site selection.
Genes Dev
7
,
407
418
Woppmann
A.
,
Will
C. L.
,
Kornstädt
U.
,
Zuo
P.
,
Manley
J. L.
,
Luhrmann
R.
(
1993
).
Identification of an snRNP-associated kinase activity that phosphorylates arginine/serine rich domains typical of splicing factors.
Nucl. Acids Res
21
,
2815
2822
Wu
J.
,
Manley
J. L.
(
1989
).
Mammalian pre-mRNA branch site selection by U2 involves base pairing.
Genes Dev
3
,
1553
1561
Zahler
A. M.
,
Neugebauer
K. M.
,
Lane
W. S.
,
Roth
M. B.
(
1993
).
Distinct functions of SR proteins in alternative pre-mRNA splicing.
Science
260
,
219
222
Zamore
P. D.
,
Green
M. R.
(
1989
).
Identification, purification and biochemical characterization of U2 small nuclear ribonucleoprotein auxiliary factor.
Proc. Nat. Acad. Sci. USA
86
,
9243
9247
Zamore
P. D.
,
Green
M. R.
(
1991
).
Biochemical characterization of U2 snRNP auxiliary factor: an essential pre-mRNA splicing factor with a novel intranuclear distribution.
EMBO J
10
,
207
214
Zamore
P. D.
,
Patton
J. G.
,
Green
M. R.
(
1992
).
Cloning and domain structure of the mammalian splicing factor U2AF.
Nature
355
,
609
614
Zeitlin
S.
,
Wilson
R. C.
,
Efstratiadis
A.
(
1989
).
Autonomous splicing and complementation of in vivo-assembled splicesomes.
J. Cell Biol
108
,
765
777
Zerivitz
K.
,
Kreivi
J.-P.
,
Akusjärvi
G.
(
1992
).
Evidence for a HeLa splicing activity that is necessary for activation of a regulated adenovirus 3splice site.
Nucl. Acids Res
20
,
3955
3961
Zhuang
Y.
,
Goldstein
A. M.
,
Weiner
A. M.
(
1989
).
UACUAAC is the prefered branch site for mammalian mRNA splicing.
Proc. Nat. Acad. Sci. USA
86
,
2752
2756
Zhuang
Y.
,
Weiner
A. M.
(
1986
).
A compensatory base change in U1 snRNA suppresses a 5splice site mutation.
Cell
46
,
827
835
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