Keywords:
PCNA, DNA replication, growth regulation., domain proteins binds to PCNA’s 5′, flanking sequence (Yamaguchi et al. 1990).

The proliferating cell nuclear antigen (PCNA) is a nuclear protein of about 29000Mr, which was independently discovered by Miyachi et al. (1978) as PCNA and by Bravo and Celis (1980) as cyclin. More recently it has been identified as the co-factor of DNA polymerase delta (Prelich et al. 1987a; Bravo et al. 1987), a protein that had been previously isolated by Tan et al. (1986). Both DNA polymerases a and delta are necessary for DNA replication (Tsurimoto and Stillman, 1989). As the co-factor of DNA polymerase delta, PCNA is therefore necessary for DNA replication (Prelich et al. 1987a,b; Bravo et al. 1987). The relationship between DNA polymerase delta and PCNA has been reviewed recently by Fairman (1990). According to Stillman and co-workers PCNA is necessary for the synthesis of the leading and lagging strands...

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