The Picornaviridae are a family of numerous human pathogens (enteroviruses and rhinovirus, altogether over 180 serotypes) that cause a bewildering array of disease syndromes. Well-known animal viruses such as encephalomyocarditis virus (EMC), a cardiovirus, and the economically important foot- and-mouth disease virus (FMDV), an aphthovirus, also belong to the Picornaviridae. The chemical and three-dimensional structures of several of these viruses have been solved (Kitamura et al. 1981; Forss et al. 1984; Palmenberg et al. 1984; Stanway et al. 1984; Potratz el al. 1984; Rossmann et al. 1985; Hogle et al. 1985). Moreover, the fine structure of the genetic map of some picornaviruses has been elucidated. Thus, the Picornaviridae may be the best characterized virus family to date (for references, see Koch & Koch, 1985; Rueckert, 1985; Kuhn & Wimmer, 1986; Nicklinei al. 1986;...

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