Mutant isolation and characterization
Mutant sources
Mutagen-sensitive mutants (mus)
Meiotic mutants (met)
Mutations producing gene and chromosome instability
Genetic and cytological analyses
Mutant influences on meiosis
Mutant influences on mutation
Identification of defects in DNA repair
Photorepair
Excision repair
Postreplication repair
Additional repair processes
Molecular cloning of DNA repair genes
Cloning strategy
Mutation induction by transposon tagging
Progress report
Enzymology related to DNA repair
In the analysis of eukaryotic DNA repair Drosophila provides a valuable link between studies being conducted in unicellular organisms and mammals. On the one hand, many of the refined genetic tools available in fungi for identifying and characterizing repair-related genes have been employed with Drosophila (see Generoso et al. 1980). Like mammals, however, Drosophila is a complex multicellular organism with separate somatic and germ cell lines. This combination of properties permits a detailed genetic analysis of repair functions and their...
