Inositol lipids phosphorylated at the 3-OH position, such as PtdIns(3,4)P2 and PtdIns(3,4,5)P3, play important roles in cell migration, cell proliferation and membrane trafficking. Generated by PI 3-kinases in response to various stimuli, these 3-phosphoinositides recruit proteins containing PH, PX or FYVE domains to specific membrane sites, where they can regulate downstream signalling. Phosphatases including PTEN then switch off signalling by removing the 3-phosphate group. To characterize 3-phosphoinositide signalling in Dictyostelium chemotaxis and phagocytosis, Cornelius Weijer and co-workers have used GFP-tagged contracts containing various different PH domains to monitor these phospholipids (see p. 6497). Their approach yields several unexpected results. For example, it shows that phagocytosis and chemotactic signalling both involve generation of PtdIns(3,4,5)P3 but only phagocytosis generates PtdIns(3,4)P2 – PTEN presumably converts PtdIns(3,4,5)P3 to PtdIns(4,5)P2 before PtdIns(3,4)P2 can be formed in chemotaxis. Perhaps the...
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Special Issue – Cell Biology of Mitochondria
Our special issue on ‘Cell Biology of Mitochondria’ is now complete. Explore this issue and read the Editorial from our Guest Editors Ana J. García-Sáez and Heidi McBride.
Save the date – Imaging Cell Dynamics
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Origin and evolution of mitochondrial inner membrane composition
In this Review, Kailash Venkatraman and colleagues provide an examination of the morphological similarities between prokaryotic intracytoplasmic membranes and mitochondrial inner membranes, and whether cristae evolution has driven specialisation of the mitochondrial lipidome.
Resolution in super-resolution microscopy
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