P2-type ATPases such as the plasma membrane Na+/K+-ATPase, the gastric H+/K+-ATPase and the sarcoplasmic reticulum Ca2+-ATPase are transmembrane proteins that pump metal ions across membranes. The Na+/K+-ATPase and H+/K+-ATPase each comprise a catalytic α subunit and a β subunit that is essential for correct folding. The Ca2+-ATPase has an α subunit but – despite having a topology and overall hydropathy similar to its relatives – seems to get by without a β subunit. So how can it fold correctly? Masaru Kawamura and co-workers show that it can borrow β subunits from its relatives (see p. 1875). They find that the Ca2+-ATPase can be coimmunoprecipitated with the β-subunits of the Na+/K+-ATPase and H+/K+-ATPase in oocytes during the early stages of...
Special Issue – Cell Biology of Mitochondria
Our special issue on ‘Cell Biology of Mitochondria’ is now complete. Explore this issue and read the Editorial from our Guest Editors Ana J. García-Sáez and Heidi McBride.
Save the date – Imaging Cell Dynamics
We are delighted to announce that we will be hosting a 2026 Imaging Cell Dynamics meeting. This meeting will provide a unique opportunity to bring together experts working at the interface between cell biology and imaging. Save the date for 11-14 May 2026 and register for more information.
Mitochondria–membranous organelle contacts at a glance
Antigoni Diokmetzidou and Luca Scorrano provide an overview of contacts between mitochondria and other membranous organelles, describing the interorganelle tethers involved and the factors that regulate the composition and functions of such contacts.
JCS-FocalPlane Training Grants
Early-career researchers - working in an area covered by JCS - who would like to attend a microscopy training course, please apply. Deadline dates for 2025 applications: 6 June 2025 (decision by week commencing 28 July 2025) and 5 September 2025 (decision by week commencing 20 October 2025).
JCS fast-track option
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