edited by B. R. Jordan Springer-Verlag (2001) 140 pages. ISBN 3-540-41508-4£31.50/$49
Much has been written about DNA microarray technology in recent years. But,for the complete novice, gathering enough information to be able to plan and conduct one's own experiments remains a great challenge. DNA microarrays are now widely used and are increasingly the method of choice for investigating changes in gene expression, and so a guide to the different systems and to data acquisition and analysis techniques would be very welcome. Jordan has assembled a collection of articles aiming to do just that. Part of the Springer `Principles and Practice' series, the book begins with an historical overview, following the development from Hans Lehrach's colony filters to Affymetrix's oligonucleotide chips. Separate chapters are dedicated to different microarray platforms: cDNA arrays on glass slides; nylon membranes for radioactive or calorimetric detection; and Affymetrix oligonucleotide chips. Each system is explained in detail,...
