edited by Roger H. Pain. Oxford University Press (2000) 433 pages. ISBN 0-19-963788-1 £35
Even after many years of research by numerous groups, our understanding of protein folding is still not at the stage where the structure of a protein can be predicted from its amino acid sequence alone, even though the experiments of Anfinsen in the 60s demonstrated this should be possible in principle. This second edition of Mechanisms of Protein Folding, like the first, is focused on the experimental study of protein folding. Although only seven years have passed since the first edition, there has been a remarkable expansion in our knowledge of in vitro and in vivo protein folding during this period. There have been the impressive crystal structures of GroEL and other chaperones, and major enhancements in experimental techniques to study protein folding, in particular to look at the very early stages of folding.
The...
