Protein kinase C (PKC) consists of a family of serine/threonine protein kinases which are presumed to play a major role in signal transduction in response to the production of diacylglycerol (reviewed by Nishizuka, 1988; Parker et al. 1989). Originally defined as a kinase dependent on phospholipid and calcium for activity, PKC was found to be the major cellular receptor for the tumourpromoting phorbol esters, and the addition of either phorbol esters or diacylglycerol to the enzyme in vitro increases the affinity for phospholipid and calcium such that the kinase is fully active at physiological concentrations of these effectors. Subsequent isolation of cDNA clones encoding at least nine different PKC proteins from a minimum of seven genes (Parker et al. 1986; Coussens et al. 1986; Ono et al. 1987; Coussens et al. 1987; Ono et al. 1989a;...
Interviews with Biologists @ 100 conference speakers
Explore our interviews with keynote speakers from the Biologists @ 100 conference, hosted to celebrate our publisher’s 100th anniversary, where we discuss climate change and biodiversity with Hans-Otto Pörtner and Jane Francis, health and disease with Charles Swanton and emerging technologies with Manu Prakash and Jennifer Lippincott-Schwartz.
Introducing our new Associate Editors
In this Editorial, JCS Editor-in-Chief Michael Way welcomes five new Associate Editors to the JCS team. These Associate Editors will expand our support for the wider cell biology community and handle articles in immune cell biology, proteostasis, imaging and image analysis, plant cell biology, and stem cell biology and modelling.
The spatial choreography of mRNA biosynthesis
In their Review, André Ventura-Gomes and Maria Carmo-Fonseca detail the latest research progress and technological advancements that are helping to unlock how nuclear organisation underpins control of gene transcription and pre-mRNA splicing.
JCS-FocalPlane Training Grants
Early-career researchers - working in an area covered by JCS - who would like to attend a microscopy training course, please apply. Deadline dates for 2025 applications: 6 June 2025 (decision by week commencing 28 July 2025) and 5 September 2025 (decision by week commencing 20 October 2025).
The emerging roles of the endoplasmic reticulum in mechanosensing and mechanotransduction
In their Review, Jonathan Townson and Cinzia Progida highlight recently emerging evidence for a role of the endoplasmic reticulum in enabling a cell to sense and respond to changes in the extracellular mechanical environment.
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